Science Inventory

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Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS). Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25451677

Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS) (Toxics). Toxics. MDPI, Basel, Switzerland, 12(4):271, (2024). https://doi.org/10.3390/toxics12040271

Patlewicz, G., A. Williams, M. Adams, I. Shah, AND K. Friedman. A cheminformatics workflow to select representative TSCA chemicals for New Approach Methodology (NAM) screening. SOT, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25395526

Patlewicz, G., P. Karamertzanis, M. Sannicola, K. Friedman, AND I. Shah. A systematic comparison of read-across within REACH registration dossiers with Generalised Read-Across (GenRA). SOT, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25395493

Browne, P., K. Friedman, K. Boekelheide, AND R. Thomas. Adverse effects in traditional and alternative toxicity tests. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 148:105579, (2024). https://doi.org/10.1016/j.yrtph.2024.105579

Friedman, K. Applied NAMs for Hazard. Lecture in ENVR5000 at UNC Chapel Hill, Chapel Hill, NC, April 16, 2024. https://doi.org/10.23645/epacomptox.25665117

Friedman, K. Evaluating Endocrine Bioactivity Data Using ToxCast Data and Models. Presented at Trainings on-site at the EFSA Endocrine Working Group, Parma, ITALY, January 30 - February 01, 2024. https://doi.org/10.23645/epacomptox.25219901

Mayil Vahanan, M., T. Shafer, K. Friedman, AND K. Carstens. Evaluating two analysis methods for the microelectrode array network formation assay. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25565175

Thunes, C., J. Brown, A. Ko, A. Rashid, N. Sipes, K. Friedman, AND M. Feshuk. Exploring ToxCast’s invitroDB : Increasing public accessibility to targeted bioactivity screening data. SOT, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25395664

Harrill, J., L. Everett, D. Haggard, J. Bundy, C. Willis, I. Shah, K. Friedman, D. Basili, A. Middleton, AND R. Judson. Exploring the Effects of Experimental Parameters and Data Modeling Approaches on In Vitro Transcriptomic Point-of-Departure Estimates. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 501:153694, (2024). https://doi.org/10.1016/j.tox.2023.153694

Rogers, J., F. Leusch, B. Chambers, K. Daniels, L. Everett, R. Judson, K. Maruya, A. Mehinto, P. Neale, K. Friedman, R. Thomas, S. Snyder, AND J. Harrill. High-Throughput Transcriptomics of Water Extracts Detects Reductions in Biological Activity with Water Treatment Processes. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 58(4):2027-2037, (2024). https://doi.org/10.1021/acs.est.3c07525

Truong, K., D. Kapraun, S. Davidson-Fritz, J. Wambaugh, S. Degitz, J. Olker, M. Hornung, R. Judson, AND K. Friedman. In Vitro-In Vivo Extrapolation of Thyroid-Related Endpoints with Higher Throughput Pregnancy PBPK Modeling. Quantitative Systems Pharmacology (QSP) Summit Cambridge 2024, Cambridge, MA, May 01, 2024. https://doi.org/10.23645/epacomptox.25765788

Friedman, K. Moving toward Next-Generation Risk Assessment with High-Throughput In Vitro to In Vivo Extrapolation. Society of Toxicology 2024 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25475716

Friedman, K. New Approach Methods for Hazard. Lecture at UNC Chapel Hill in ENVR5000, Chapel Hill, NC, March 21, 2024. https://doi.org/10.23645/epacomptox.25602417

Friedman, K. Qualitative and Quantitative Variability of Repeat Dose Animal Toxicity Studies (Health Canada 2024). Webinar for Health Canada Modernized Approaches to Risk Sciences Working Group, online, CANADA, January 17, 2024. https://doi.org/10.23645/epacomptox.24937140

Feshuk, M., J. Brown, S. Davidson-Fritz, AND K. Friedman. Software and Database Enhancements to ToxCast™ for Accessible Bioactivity Data for Toxicology. Presented at CompTox Communities of Practice Seminar, virtual, NC, January 25, 2024. https://doi.org/10.23645/epacomptox.25122179

Friedman, K. ToxCast Tools for Users. ToxCast Training for ANSES, virtualF, February 08, 2024. https://doi.org/10.23645/epacomptox.25607745

Friedman, K. ToxCast: Tools for Users. Presentation to EFSA regulatory toxicology group, Parma, ITALY, January 30 - February 01, 2024. https://doi.org/10.23645/epacomptox.25190339

Friedman, K. Training the future leaders of computational toxicology. Society of Toxicology 2024 Annual Meeting, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25475785

Rogers, J., J. Bundy, J. Harrill, R. Judson, L. Everett, AND K. Friedman. Transcriptomics and cell morphology screens complement each other when grouping chemicals with similar bioactivity. Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25521205

Friedman, K. An Update on New Approach Methods (NAMs) in the Center for Computational Toxicology and Exposure (CCTE). American Cleaning Institute, Washington, DC, DC, June 14, 2023. https://doi.org/10.23645/epacomptox.23561367

Eytcheson, S., J. Olker, K. Friedman, M. Hornung, AND S. Degitz. Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 144:105491, (2023). https://doi.org/10.1016/j.yrtph.2023.105491

Wetmore, B., K. Friedman, K. Carstens, J. Harrill, J. Wambaugh, T. Shafer, K. Houck, R. Judson, AND G. Patlewicz. Category-based toxicity and toxicokinetic evaluations of per- and polyfluoroalkyl substances (PFAS) for new approach method (NAM) application (SERMACS 2023). SERMACS, Durham, NC, October 25 - 28, 2023. https://doi.org/10.23645/epacomptox.24790650

Shafer, T., M. Martin, A. Carpenter, K. Friedman, AND K. Carstens. Comparisons of Microelectrode Array Acute and Network Formation In Vitro Assays for Evaluating Neurotoxicity. Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22750703

Patlewicz, G., K. Friedman, K. Houck, L. Zhang, R. Huang, M. Xia, J. Brown, AND S. Simmons. Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 26:100271, (2023). https://doi.org/10.1016/j.comtox.2023.100271