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Records 1 to 25 of 38 records from author Robert Pearce

2022
Wambaugh, J., S. Davidson, R. Pearce, M. Devito, M. Linakis, G. Honda, E. Kenyon, Tom Purucker, C. Ring, M. Sfeir, AND Woodrow Setzer. Developing Generic Toxicokinetic Models with R Package “httk” for Enhanced Reporting Accuracy and Statistical Evaluation. Society of Toxicology Annual Meeting, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19355456
Wambaugh, J., M. Sfeir, R. Pearce, S. Davidson, A. Lumen, A. Dallmann, R. Judson, AND J. Wambaugh. Evaluation of a Rapid, Generic Human Gestational Dose Model. HTTK Community of Practice, RTP, NC, May 26, 2022. https://doi.org/10.23645/epacomptox.19891357
Kapraun, D., M. Sfeir, R. Pearce, S. Davidson, A. Lumen, A. Dallmann, R. Judson, AND J. Wambaugh. Evaluation of a rapid, generic human gestational dose model (Manuscript). REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 113:172-188, (2022). https://doi.org/10.1016/j.reprotox.2022.09.004
2020
Linakis, M., R. Sayre, R. Pearce, Mark A. Sfeir, N. Sipes, H. Pangburn, J. Gearhart, AND J. Wambaugh. Development and Evaluation of a High Throughput Inhalation Model for Organic Chemicals. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 30(5):866-877, (2020). https://doi.org/10.1038/s41370-020-0238-y
Sfeir, Mark A., D. Kapraun, A. Lumen, R. Judson, L. Aylward, D. Abrahamsson, T. Woodruff, C. Carignan, J. Rager, R. Sayre, R. Pearce, AND J. Wambaugh. Evaluation of a Rapid, Multi-Chemical Human Gestational Dose Model. SOT, Anaheim, CA, March 15 - 19, 2020. https://doi.org/10.23645/epacomptox.22572913
Wambaugh, J., M. Linakis, M. Evans, K. Isaacs, R. Sayre, Chris Grulke, R. Pearce, Mark A. Sfeir, M. Breen, N. Sipes, H. Pangburn, AND J. Gearhart. High Throughput Toxicokinetic (HTTK) Modeling of Inhalation Exposures. American Chemical Society Annual Meeting, Virtual, California, August 17 - 20, 2020. https://doi.org/10.23645/epacomptox.16663450
Pradeep, P., G. Patlewicz, R. Pearce, J. Wambaugh, B. Wetmore, AND R. Judson. Using Chemical Structure Information to Develop Predictive Models for In Vitro Toxicokinetic Parameters to Inform High-throughput Risk-assessment. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 16:100136, (2020). https://doi.org/10.1016/j.comtox.2020.100136
2019
Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, AND R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2):235-251, (2019). https://doi.org/10.1093/toxsci/kfz205
Linakis, M., R. Sayre, R. Pearce, N. Sipes, H. Pangburn, J. Gearhart, AND J. Wambaugh. Development of a Generalized Inhalation Model for use with the High-Throughput Toxicokinetics (httk) Package in R. Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 10 - 14, 2019. https://doi.org/10.23645/epacomptox.9104819
Honda, G., R. Sayre, C. Strock, D. Angus, R. Dinallo, R. Pearce, R. Thomas, AND J. Wambaugh. QSAR Modeling of Caco-2 Permeability for the Estimation of Oral Bioavailability. Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 10 - 14, 2019. https://doi.org/10.23645/epacomptox.7841102
Wambaugh, J., R. Pearce, C. Strope, Woodrow Setzer, AND N. Sipes. R Package httk. U.S. Environmental Protection Agency, Washington, DC, 2019.
Honda, G., R. Pearce, L. Pham, R. Setzer, B. Wetmore, N. Sipes, J. Gilbert, B. Franz, R. Thomas, AND J. Wambaugh. Using the Concordance of In Vitro and In Vivo Data to Evaluate Extrapolation Assumptions. PLOS ONE . Public Library of Science, San Francisco, CA, 14(5):1-33, (2019). https://doi.org/10.1371/journal.pone.0217564
2018
Honda, G., R. Pearce, AND J. Wambaugh. Advances in High Throughput Toxicokinetics. Presented at International Council of Chemical Associations Long-Range Research Initiative (ICCA-LRI) Workshop, Ottawa, CANADA, June 20 - 21, 2018. https://doi.org/10.23645/epacomptox.6951446
Honda, G., R. Pearce, L. Pham, B. Wetmore, N. Sipes, Woodrow Setzer, R. Thomas, AND J. Wambaugh. Applying a High-Throughput PBTK Model for IVIVE. Presented at Society of Toxicology Annual Meeting, San Antonio, TX, March 11 - 15, 2018.
Wambaugh, J., M. Hughes, C. Ring, D. MacMillan, J. Ford, T. Fennell, S. Black, R. Snyder, N. Sipes, B. Wetmore, J. Westerhout, Woodrow Setzer, R. Pearce, J. Simmons, AND R. Thomas. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1):152-169, (2018). https://doi.org/10.1093/toxsci/kfy020
Wambaugh, J., B. Wetmore, R. Pearce, G. Honda, R. Sayre, K. Paul-Friedman, Woodrow Setzer, AND R. Thomas. Evaluating New Approach Methodologies for Toxicokinetics. International Society of Exposure Science annual meeting, OttawaCON, August 26 - 30, 2018. https://doi.org/10.23645/epacomptox.7072652
Honda, G., C. Strock, D. Angus, R. Dinallo, R. Pearce, R. Thomas, AND J. Wambaugh. In Vitro Characterization of Oral Absorption of Non-Pharmaceutical Chemicals. Presented at Society of Toxicology Annual Meeting, San Antonio, Texas, March 11 - 15, 2018. https://doi.org/10.23645/epacomptox.6863801
Wambaugh, J., J. Jackson, K. Brouwer, A. Herman, G. Honda, R. Pearce, AND R. Thomas. In Vitro Hepatobiliary Disposition Assessment of 15 Non-Therapeutic Chemicals in Sandwich-Culture Rat Hepatocytes using B-CLEAR® Technology. Presented at Society of Toxicology Annual Meeting, San Antonio, Texas, March 11 - 15, 2018. https://doi.org/10.23645/epacomptox.6987284
Pearce, R., R. Sayre, Woodrow Setzer, Chris Grulke, R. Thomas, AND J. Wambaugh. Replication of PBTK Models for Bisphenol A with High-Throughput TK Models. Presented at Society of Toxicology Annual Meeting, San Antonio, Texas, March 11 - 15, 2018. https://doi.org/10.23645/epacomptox.7017293
Wambaugh, J., B. Wetmore, D. Angus, C. Strock, M. Bacolod, C. Nicolas, C. Ring, R. Pearce, Woodrow Setzer, AND R. Thomas. Uncertainty and Variability in High-Throughput Toxicokinetics for Risk Prioritization. Society of Toxicology Annual Meeting, San Antonio,TX, March 11 - 15, 2018.
2017
Sipes, N., J. Wambaugh, R. Pearce, S. Auerbach, B. Wetmore, J. Hsieh, A. Shapiro, D. Sboboda, M. DeVito, AND S. Ferguson. An Intuitive Approach for Predicting Human Risk with the Tox21 10k Library. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, (51):10786-10796, (2017).
Wambaugh, J., R. Pearce, G. Honda, M. Hughes, C. Ring, L. Pham, B. Wetmore, AND Woodrow Setzer. Evaluating High Throughput Toxicokinetics and Toxicodynamics for IVIVE (WC10). Presented at World Congress on Alternatives and Animal Use in the Life Sciences, Washington, Seattle, August 20 - 24, 2017.
Pearce, R., Woodrow Setzer, J. Davis, AND J. Wambaugh. Evaluation and Calibration of High-Throughput Predictions of Chemical Distribution to Tissues. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. Springer, New York, NY, 44(6):549-565, (2017). https://doi.org/10.1007/s10928-017-9548-7
Pearce, R., Woodrow Setzer, C. Strope, N. Sipes, AND J. Wambaugh. HTTK: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software. American Statistical Association, Alexandria, VA, 79(4):1-26, (2017).
Ring, C., R. Pearce, Woodrow Setzer, B. Wetmore, AND J. Wambaugh. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 106:105-118, (2017).