Science Inventory

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MedlockKakaley, E., N. Evans, J. Conley, E. Gray, P. Bradley, K. Smalling, AND K. Romanok. Effects-based bioassay screening approaches applied to residential tapwater to inform consumer point-of-use decisions. Society of Environmental Toxicology and Chemistry, Louisville, KY, November 12 - 16, 2023.

Gray, E. 30 Years After Wingspread: Development of Quantitative Adverse Outcome Pathways for Endocrine Disrupting Chemicals (EDCs) that Alter Reproductive Development in Utero. SOT of CANADA, Ottawa, Ontario, CANADA, November 30 - December 02, 2022.

Conley, J., C. Lambright, N. Evans, E. MedlockKakaley, D. Hill, M. Strynar, AND E. Gray. Developmental toxicity of emerging perfluoroalkyl ether carboxylic acids of varying chain length: PFMOAA, PFO4DA and PFO5DoA. Society for Birth Defects Research and Prevention, Raleigh, NC, June 25 - 29, 2022.

Conley, J., C. Lambright, N. Evans, E. MedlockKakaley, D. Hill, J. Ford, J. McCord, M. Strynar, AND E. Gray. Evaluation of dose additive effects of combined oral maternal exposure to PFOA and PFOS during pregnancy in the Sprague-Dawley rat. 2022 Society of Toxicology Annual Meeting, San Diego, CA, March 27 - 31, 2022.

Gray, E., J. Conley, C. Lambright, AND J. FURR. In utero exposure to a mixture of the perfluoroalkyl-isopropyl pesticide pyrifluquinazon with dibutyl phthalate cumulatively disrupts male rat reproductive development via different mechanisms of action. Birth Defects Research and Prevention BDRP 2022, VANCOUVER, BRITISH COLOMBIA, CANADA, June 25 - 29, 2022.

Gray, E., J. Conley, C. Lambright, AND J. Furr. In utero exposure to a mixture of the perfluoroalkylisopropyl pesticide pyrifluquinazon with dibutyl phthalatecumulatively disrupts male rat reproductive development via different mechanisms of action. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(2):234-247, (2022). https://doi.org/10.1093/toxsci/kfac059

Conley, J., C. Lambright, N. Evans, M. Cardon, E. MedlockKakaley, V. Wilson, AND E. Gray. A mixture of 15 phthalates and pesticides below individual chemical No Observed Adverse Effect Levels (NOAELs) produces reproductive tract malformations in the male rat. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 156(106615):1, (2021). https://doi.org/10.1016/J.ENVINT.2021.106615

MedlockKakaley, E., M. Cardon, N. Evans, C. Lambright, B. Blackwell, R. Hofer, L. Hubbard, P. Bradley, J. Conley, E. Gray, AND D. Kolpin. Biological Activity in US Food Processing Plant Effluent. SETAC Europe Annual Meeting (Virtual), Durham-Virtual, NC, May 03 - 06, 2021.

Gray, E., C. Lambright, N. Evans, V. Wilson, B. Hannas, P. Foster, AND J. Conley. Biological Relevance of Phthalate-Induced Disruption of Fetal Testis Hormones and Gene Expression: Key Events in a Novel AOP. Society of Toxicology - Virtual, NA, Virtual, March 12 - 26, 2021.

Gray, E. AND J. Conley. Characterization of developmental toxicity and Adverse Outcome Pathways for emerging PFAS - individual compounds and mixtures. SOT Risk Assessment and Mixtures Specialty Sections Joint Webinar Series-Virtual, NA, Virtual, January 13, 2021.

Conley, J., C. Lambright, N. Evans, E. MedlockKakaley, D. Hill, A. Dixon, E. Hines, AND E. Gray. Dose additive developmental toxicity of a mixture of three PFAS (HFPO-DA, NBP2, PFOS) in the Sprague-Dawley rat. 2021 Society of Toxicology Annual Meeting-Virtual, NA, Virtual, March 12 - 26, 2021.

MacMillan, D., N. Evans, E. Gray, C. Lambright, AND J. Conley. Exploring Potential Differences in Developmental Toxicology of Per- and Polyfluoroalkyl Substances (PFAS) Through Targeted Metabolomics. American Society for Mass Spectrometry Conference, Philadelphia, Pennsylvania, October 30 - November 04, 2021. https://doi.org/10.23645/epacomptox.16840390

Conley, J., C. Lambright, N. Evans, E. MedlockKakaley, AND E. Gray. Exposure to a mixture of PFOA and PFOS during pregnancy produces cumulative effects on F1 bodyweight, liver weight, and survival in the Sprague-Dawley rat. FLUOROS Global 2021, Providence, RI, October 03 - 07, 2021.

Gray, E., C. Lambright, J. Conley, N. Evans, J. Furr, B. Hannas, V. Wilson, H. Sampson, AND P. Foster. Genomic and Hormonal Biomarkers of Phthalate-Induced Male Rat Reproductive Developmental Toxicity Part II: A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 182(2):195-214, (2021). https://doi.org/10.1093/toxsci/kfab053

Gray, E. Health Canada Course: Effects of in utero, pubertal and adult exposures to toxicants on the male and female reproductive system. Pest Management Regulatory Agency Repro/Endo Course: Virtual, Ontario, Ontario, CANADA, February 17 - 18, 2021.

Conley, J., C. Lambright, N. Evans, J. McCord, M. Strynar, D. Hill, E. MedlockKakaley, V. Wilson, AND E. Gray. Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight and hepatomegaly in the Sprague-Dawley rat. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 146:106204, (2021). https://doi.org/10.1016/j.envint.2020.106204

Gray, E. In utero exposure to a mixture of the perfluoroalkyl pesticide pyrifluquinazon and dibutyl phthalate disrupt male rat reproductive development in a dose additive manner. FLUROS Global 2021-Virtual, Providence, Rhode Island, October 03 - 08, 2021.

Medlock Kakaley, E., M. Cardon, N. Evans, L. Iwanowicz, J. Allen, E. Wagner, H. Hur, K. Bokenkamp, S. Richardson, M. Plewa, P. Bradley, K. Romanok, D. Kolpin, J. Conley, E. Gray, Philip Hartig, AND V. Wilson. In vitro effects-based method and water quality screening model for use in pre- and post-distribution treated waters. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 768:144750, (2021). https://doi.org/10.1016/j.scitotenv.2020.144750

Bradley, P., D. LeBlanc, K. Romanok, M. Focazio, M. Cardon, J. Clark, J. Conley, N. Evans, C. Givens, J. Gray, E. Gray, Philip Hartig, C. Higgins, M. Hladik, K. Loftin, R. McClesky, C. McDonough, E. MedlockKakaley, C. Weis, V. Wilson, L. Iwanowicz, AND K. Smalling. Public and Private Tapwater: Comparative Analysis of Contaminant Exposure and Potential Risk, Cape Cod, MA, USA. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 152(106487):1, (2021). https://doi.org/10.1016/j.envint.2021.106487

Gray, E. Quantification of the uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in male rats. Virtual-Annual Meeting of the Teratology Society, Charleston, South Carolina, June 27 - July 01, 2020.

Gray, E. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in rats. Virtual - European Crop Protection Association (ECPA) - Endocriine Disrupting Expert Group (EDEG) Meeting, Research Triangle Park, North Carolina, September 25, 2020.

Gray, E. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in rats#. Virtual - NC Society of Toxicology Meeting, Research Triangle Park, North Carolina, September 21, 2020.

Gray, E., J. Furr, J. Conley, C. Lambright, N. Evans, M. Cardon, V. Wilson, P. Foster, AND P. Hartig. A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, , 632-643, (2019). https://doi.org/10.1093/toxsci/kfz010

Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, AND E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, , 1-13, (2019). https://doi.org/10.1289/EHP4372

Gray, E. Estrogenicity and Antiandrogenicity of Bisphenols: Uncertainties in extrapolating from in vitro Molecular Initiating Events (MIE) and in vivo Key Events (KE) to Adverse Reproductive Outcomes. SOT 2019, BALTIMORE, MD, March 10 - 14, 2019.