Office of Research and Development Publications

Next >>

presentation at Michigan State University Dept. of Pharmacology and Toxicology Alternative Approaches to Chemical Risk Assessment: Assays, Databases, Models

Evaluating the thousands of chemicals that are directly added to or come in contact with food poses a great challenge due to the time, cost, and sheer volume of data necessary to thoroughly conduct comprehensive toxicological testing. This study compiled a list of food-use chemic...

Non-targeted analysis (NTA) workflows in high-resolution mass spectrometry require mechanisms for compound identification. One strategy for tentative identification is the use of online chemical databases such as ChemSpider. Databases like this use molecular formulae and monois...

The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...

Presentation at the 21st Annual Green Chemistry & Engineering Conference on Incorporating new technologies and high-throughput approaches in the design and selection of chemical alternatives

As the lower Saint Louis River moves closer and closer to delisting as an Area of Concern, it is incumbent that we measure, assess and report on our success. Going forward, It’s equally important that we continue monitoring to protect and sustain the healthy ecosystems we&...

During the 2015 Lake Michigan CSMI effort we collected continuous undulating tow and autonomous glider data including conductivity, temperature, depth, fluorescence, and backscatter across the northern half of Lake Michigan. During the same period, we also collected discreet vert...

The webinar focused on ways that ToxCast high throughput screening data and the adverse outcome pathway framework, under development in the CSS program, can be used to prioritize environmental contaminants for monitoring and management.

Presentation to be given at the AWWA WQTC in Portland, OR.

The U.S. EPA’s Office of Research and Development (ORD) has developed a 3-D computational fluid dynamics (CFD) model of the human respiratory system that allows for the simulation of particulate based contaminant deposition and clearance, while being adaptable for age, ethnicity,...

On May 8, 2017, the NCA4 Air Quality chapter team held a public engagement webinar. The objectives of the webinar were to gather input from stakeholders, including authors of the regional chapters, to help inform the writing and development of NCA4, and to raise awareness of the ...

Current guideline studies for developmental neurotoxicology (DNT) hazard are resource and time intensive, and therefore have only been conducted for a limited set of compounds. The EPA is developing more efficient methods to screen and prioritize the thousands of chemicals with u...

The frequency of cyanobacteria blooms in North American lakes is increasing. A major concernwith rising cyanobacteria blooms is microcystin, a common cyanobacterial hepatotoxin. Toexplore the conditions that promote high microcystin concentrations, we analyzed the US EPANational ...

The frequency of cyanobacteria blooms in North American lakes is increasing. A major concern with rising cyanobacteria blooms is microcystin, a common cyanobacterial hepatotoxin. To explore the conditions that promote high microcystin concentrations, we analyzed the US EPA Nation...

Restoring urban infrastructure and managing the nitrogen cycle represent emerging challenges for urban water quality. We investigated whether stormwater control measures (SCMs), a form of green infrastructure, integrated into restored and degraded urban stream networks can influe...

Wildfire smoke is a major contributor to ambient air pollution levels. In this talk, we develop a spatio-temporal model to estimate the contribution of fire smoke to overall air pollution in different regions of the country. We combine numerical model output with observational da...

Exposure to air pollution is a leading cause of cardiopulmonary morbidity and mortality; however, while these effects outside the lung have been associated with aberrant oxidative stress and inflammation, the underlying molecular mechanisms are poorly understood. We hypothesized ...

When participants in the 2016 St Louis River Summit identified their roles and described their interactions with the estuary on the 50-year timeline, they were illustrating the community that built and is now implementing the Remedial Action Plan. From its inception, the Great La...

High resolution mass spectrometry (HRMS) data has revolutionized the identification of environmental contaminants through non-targeted analyses (NTA). However, data processing and chemical identification and prioritization remain challenging due to the vast number of unknowns ob...

Engineered nanomaterials (ENM) are a fundamental and growing component of the global economy, and are projected to reach an annual economic impact in the hundreds of billions of dollars. Currently, their growing use far outpaces our ability to evaluate potential for adverse impac...

Engineered nanomaterials (ENM) are a fundamental and growing component of the global economy, and are projected to reach an annual economic impact in the hundreds of billions of dollars. Currently, their growing use far outpaces our ability to evaluate potential for adverse impac...

An open initiative involving cross-disciplinary contributors of computer-assisted structure elucidation (CASE), including methodology specialists, software and database developers and the editorial board of Magnetic Resonance in Chemistry, is addressing the old problem of reporti...

Low-Density polyethylene (LDPE) sheets are often used as passive samplers for aquatic environmental monitoring to measure the freely dissolved concentrations of hydrophobic organic contaminants (HOCs). HOCs that are freely dissolved in water (Cfree) will partition into the LDPE u...

The value of models that link organism-level impacts to the responses of a population in ecological risk assessments (ERA) has been demonstrated extensively over the past few decades. There is little debate about the utility of these models to translate multiple organism-level en...

Convective adjustment timescale (τ) for cumulus clouds is one of the most influential parameters controlling parameterized convective precipitation in climate and weather simulation models at global and regional scales. Due to the complex nature of deep convection, a pres...