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Adverse Outcome Pathways (AOPs) organize toxicological knowledge from the molecular level up to the population level, providing evidence-based causal linkages at each step. The AOPWiki serves as a repository of AOPs. With the international adoption of the AOP framework, the AOPw...

The University of Rhode Island’s Watershed Watch Volunteer Monitoring Program has been collecting water quality data on dozens of Rhode Island lakes and ponds for over 25 years, allowing exploration of long-term trends in common water quality parameters. Not all lakes and p...

Graphene family nanomaterials (GFNs) are widely used in the field of electronics and biomedicine. Gaps in our knowledge about fate and toxicity of GFNs, such as graphene oxide (GO), raise concerns regarding their environmental impacts. Filter feeding bivalves, such as Crassostrea...

A high level presentation for their senior people, lasting perhaps 45 minutes, covering a history of the protocol program, outcome focused… the why’s and how’s, and how you measure success.

The National Research Council (1983) identified chemical risk as a function of both inherent hazard and exposure. To address thousands of chemicals, we need to use “high throughput methods” to prioritize chemicals for additional study. High throughput risk prioritization needs: h...

Adult cardiac stem cells (CSC) and progenitor cells (CPC) represent a population of cells in the heart critical for its regeneration and function over a lifetime. The impact of chemicals on adult human CSC/CPC differentiation and function is unknown. Research was conducted to dev...

From the earliest days of public health, environmental protection has been fundamental to preventing disease and ensuring a healthy population. From John Snow and the Broad Street Pump to chlorinated drinking water in Jersey City, NJ, protecting the environment has been a core pu...

The performance of a constructed, variable-flow treatment wetland was evaluated for its ability to reduce bacterial loads from the Banklick Creek, an impacted recreational waterway in Northern Kentucky. Historically, culturable fecal indicator (coliforms and E. coli) bacteria me...

Detailed chemical risk assessments are time-consuming and difficult to compile, leading to regulatory mandates to prioritize chemicals for further assessment. Multiple regulatory bodies (EPA, ECHA, Health Canada) are currently tasked with prioritizing chemicals for data collecti...

Increases in brain-derived neurotrophic factor (Bdnf), Ca2+/calmodulin-dependent protein kinase II alpha (Camk2a), and cyclic adenosine monophosphate (cAMP) response element binding (Creb1) gene expression have been associated with learning in a variety of different rodent studie...

Stress tests are used clinically to uncover underlying disease and predict future cardiovascular risk. Previously, we used treadmill exercise stress in rats to reveal latent effects of air pollution inhalation. Other daily stressors, when modeled experimentally, may have similar ...

Health Canada assesses the health risks posed by chemicals in commerce in Canada. An important endpoint in chemical assessment is genetic toxicity (e.g., ability to damage DNA) which is associated with cancer and inherited genetic diseases. The in vitro micronucleus (MN) assay is...

Arsenic is one of the most interesting and enigmatic elements of the periodic table. Its use as an intentional poison has been known for centuries and occasionally occurs today. Arsenic has been called the “King of Poisons”, because it had been used to poison royalt...

Exposure to mixtures is frequent, but biologic pathways such as metabolic inhibition, are poorly understood. CHCl3 and TCE are model volatiles frequently co-occurring; combined exposure results in less than additive hepatotoxicity. Here, we explore the underlying metabolic inte...

Background Air pollution risk assessments often employ effect coefficients from epidemiologic studies to quantify the public health impact of changes in air quality. Partly due to data and methodological limitations, epidemiologic studies have traditionally characterized the heal...

The Model for Prediction Across Scales – Atmosphere (MPAS-A) is the meteorological foundation for a next generation global air quality modeling system currently being developed at the U.S. Environmental Protection Agency (USEPA). In recent years, meteorological fields for r...

Despite its importance to transportation safety and ecosystem health related to pollutant and nutrient deposition, the simulation of fog lags the simulation of other meteorological phenomena due in large part to its complexity and limitations of model resolution. Accordingly, th...

Green infrastructure (GI) represents a broad set of stormwater control measures practices that can be flexibly implemented to increase sewershed retention capacity, and can thereby improve on the management of water quantity and quality. Although much GI presents as formal engine...

The Adverse Outcome Pathway (AOP) framework represents an ideal tool for integrating diverse data relating chemical exposures to adverse outcomes. Glucocorticoid signaling is tightly controlled and numerous adverse health outcomes have been associated with either elevation or sup...

From determining what to have for lunch to deciding where to invest our resources, we, as individuals and societies, are constantly involved in multi-criteria assessment. Using sustainability assessment as a case study, in this talk I will demonstrate the ubiquity of multi-crite...

The Nooksack-Fraser transboundary area is home to communities with a strong base in farming, fisheries and outdoor recreation. A goal of the Nooksack-Fraser Transboundary Nitrogen (NFT-N) project is to determine the sources and fates of N in the watershed using data on energy us...

Indicators of a stream’s ability to remove nutrients provide insights on watershed integrity and stream habitat characteristics that are needed to help managers to restore stream ecosystem services. We used the Tracer Additon Spiraling Characterization Curve (TASCC) to mea...

Indicators of a stream’s ability to remove nutrients provide insights on watershed integrity and managers’ ability to restore ecosystem services based on specific characteristics of stream habitat. We used the Tracer Additon Spiraling Characterization Curve (TASCC) t...

This is the presentation for the invited lecture at Rutgers University. The lecture will be part of online course titled "Sustainability Decision Tools" in Spring 2018.

Researchers who perform air quality modeling studies usually do so on a regional scale. Typically, the boundary conditions are generated by another model which might have a different chemical mechanism, spatial resolution, and/or map projection. Hence, a necessary conversion/inte...