Office of Research and Development Publications

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Estuaries are transitive zones which experience large fluctuations in environmental parameters (temperature, dissolved oxygen, pH, etc.). The interactive effects of reduced dissolved oxygen (DO) and elevated pCO2 on estuarine organisms is not currently well understood. Ctenophore...

A next generation air quality modeling system is being developed at the U.S. EPA to enable modeling of air quality from global to regional to (eventually) local scales. We envision that the system will have three configurations: 1. Global meteorology with seamless mesh refinemen...

The representation of land use and land cover (hereby referred to as “LU”) is a challenging aspect of dynamically downscaled simulations, as a mesoscale model that is utilized as a regional climate model (RCM) may be limited in its ability to represent LU over multi-d...

We would like to know more about the risk posed by thousands of chemicals in the environment – which ones should we start with? High throughput screening (HTS) provides a path forward for identifying potential hazard, but the real world is full of more mixtures than we can test. ...

Chemical screening programs such as Tox21 and ToxCast have demonstrated the value of using quantitative, high-throughput assays to produce data for chemical prioritization and regulatory decisions. While these efforts have covered an impressive amount of biological space, with ov...

Freshwater fish are ecologically important in stream ecosystems, and they provide significant value to humans. Historically, the streams and rivers of southern New England supported moderately diverse and abundant assemblages of native fishes. Currently, these habitats are impact...

The aims of this webinar are to review current practices in the development and assessment of non-testing approaches; focussing on (Q)SAR and read-across, provide an overview of integrated approaches to testing and assessment (IATA) and where non-testing approaches fit within suc...

Estuarine organisms are adapted to frequent changes in temperature, salinity, pH, and dissolved oxygen (DO) levels. The high productivity of an estuary contributes to large changes in environmental conditions, with organismal respiration enhancing hypoxic zones, and elevating pCO...

To meet the Fish Community Objectives set for Lake Superior by the Great Lakes Fishery Commission, a key factor is the condition of the lower food web that supports productivity of fisheries. To assess the condition of lower trophic levels and inform the Lake Superior Technical C...

The talk was invited so there is no formal abstract. However, the focus of the talk is on the use of exposure information in the evaluation of risks from combined exposures to chemicals. The talk presents a bit of history and several case studies. All empirical data presented hav...

This course will introduce students to the fundamental principles of water system adaptation to hydrological changes, with emphasis on data analysis and interpretation, technical planning, and computational modeling. Starting with real-world scenarios and adaptation needs, the co...

presentation at Michigan State University Dept. of Pharmacology and Toxicology Alternative Approaches to Chemical Risk Assessment: Assays, Databases, Models

Evaluating the thousands of chemicals that are directly added to or come in contact with food poses a great challenge due to the time, cost, and sheer volume of data necessary to thoroughly conduct comprehensive toxicological testing. This study compiled a list of food-use chemic...

Non-targeted analysis (NTA) workflows in high-resolution mass spectrometry require mechanisms for compound identification. One strategy for tentative identification is the use of online chemical databases such as ChemSpider. Databases like this use molecular formulae and monois...

The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...

Presentation at the 21st Annual Green Chemistry & Engineering Conference on Incorporating new technologies and high-throughput approaches in the design and selection of chemical alternatives

As the lower Saint Louis River moves closer and closer to delisting as an Area of Concern, it is incumbent that we measure, assess and report on our success. Going forward, It’s equally important that we continue monitoring to protect and sustain the healthy ecosystems we&...

During the 2015 Lake Michigan CSMI effort we collected continuous undulating tow and autonomous glider data including conductivity, temperature, depth, fluorescence, and backscatter across the northern half of Lake Michigan. During the same period, we also collected discreet vert...

The webinar focused on ways that ToxCast high throughput screening data and the adverse outcome pathway framework, under development in the CSS program, can be used to prioritize environmental contaminants for monitoring and management.

Presentation to be given at the AWWA WQTC in Portland, OR.

The U.S. EPA’s Office of Research and Development (ORD) has developed a 3-D computational fluid dynamics (CFD) model of the human respiratory system that allows for the simulation of particulate based contaminant deposition and clearance, while being adaptable for age, ethnicity,...

On May 8, 2017, the NCA4 Air Quality chapter team held a public engagement webinar. The objectives of the webinar were to gather input from stakeholders, including authors of the regional chapters, to help inform the writing and development of NCA4, and to raise awareness of the ...

Current guideline studies for developmental neurotoxicology (DNT) hazard are resource and time intensive, and therefore have only been conducted for a limited set of compounds. The EPA is developing more efficient methods to screen and prioritize the thousands of chemicals with u...

The frequency of cyanobacteria blooms in North American lakes is increasing. A major concernwith rising cyanobacteria blooms is microcystin, a common cyanobacterial hepatotoxin. Toexplore the conditions that promote high microcystin concentrations, we analyzed the US EPANational ...

The frequency of cyanobacteria blooms in North American lakes is increasing. A major concern with rising cyanobacteria blooms is microcystin, a common cyanobacterial hepatotoxin. To explore the conditions that promote high microcystin concentrations, we analyzed the US EPA Nation...