Office of Research and Development Publications

Records 1 to 25 of 3007 Journals from ORD published between 08/21/2013 and 08/21/2018

Continuous, Near Real-Time Evaluation of Air Quality Models: An Approach for the Rapid Scientific Evolution of Modeling Systems (JOURNAL)
As the Environmental Protection Agency's flagship air pollution modeling system, the Community Multi-scale Air Quality (CMAQ) model is being required to address increasingly complex issues related to the representation of multiple pollutants species across multiple spatiotemporal...
The Dawn of Geostationary Air Quality Monitoring: Case Studies From Seoul and Los Angeles (JOURNAL)
With the near-future launch of geostationary Earth orbit (GEO) pollution monitoring satellite instruments over North America, East Asia, and Europe, the air quality community is preparing for an integrated global atmospheric composition observing system at unprecedented spatial a...
Weaver’s Historic Accessible Collection of Synthetic Dyes: A Cheminformatics Analysis (JOURNAL)
We present the Max Weaver Dye Library, a collection of ~98,000 vials of custom-made and largely sparingly water-soluble dyes. Two years ago, the Eastman Chemical Company donated the Library to North Carolina State University. This unique collection of chemicals, housed in the Col...
Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion (JOURNAL)
We describe the identification of synthetic hydrogels that promote robust in vitro network formation by human endothelial cells for detecting putative vascular disrupting chemicals. A hydrogel array format identified substrates that promoted endothelial network formation by prima...
Uncertainty Quantification in ToxCast High Throughput Screening (JOURNAL)
High throughput screening (HTS) projects like the U.S. Environmental Protection Agency's ToxCast program are required to address the large and rapidly increasing number of chemicals for which little to no toxicity data are available. Concentration-response parameters such as pote...
The New Alchemy: Online Networking, Data Sharing and Research Activity Distribution Tools for Scientists (JOURNAL)
There is an abundance of free online tools accessible to scientists and others that can be used for online networking, data sharing and measuring research impact. Despite this, few scientists know how these tools can be used or fail to take advantage of using them as an integrate...
Systems Toxicology: Real World Applications and Opportunities (JOURNAL)
Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical endpoints to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology entails the integration of...
Programming Microphysiological Systems for Children’s Health Protection (JOURNAL)
Microphysiological systems (MPS) and computer simulation models that recapitulate the underlying biology and toxicology of critical developmental transitions are emerging tools for developmental effects assessment of drugs/chemicals. Opportunities and challenges exist for their a...
Open Science for Identifying “Known Unknown” Chemicals (JOURNAL)
High resolution mass spectrometry (HR-MS) has expanded assessment of chemical exposure in the environment well beyond screening for a limited subset of target (“known”) chemicals. “Suspect screening” has evolved into an efficient and popular way to screen for hundreds to thousand...
In vitro to in vivo extrapolation for high throughput prioritization and decision making (JOURNAL)
Human-based in vitro chemical safety testing methods provide efficient and economical tools with the potential to provide relevant assessments of human health risk. Realizing this potential requires the availability of methods to relate in vitro effects to in vivo responses, i.e....
Confirmation of High-Throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays (JOURNAL)
Quantitative high-throughput (qHTS) testing formats have gained acceptance and widespread recognition in the field of toxicity testing of environmental compounds in recent years. As a result, significant progress has been made with respect to identification of compounds that modu...
Comprehensive analyses and prioritization of Tox21 10K chemicals affecting mitochondrial function by in-depth mechanistic studies (JOURNAL)
The Tox21 program is re-focusing toxicity testing from animal studies to less expensive and higher throughput in vitro methods using target/pathway-specific, mechanism-driven assays. Consistent with this effort, we used a tiered testing approach to prioritize for more extensive t...
Blood-Brain Barrier Development: Systems Modeling and Predictive Toxicology (JOURNAL)
The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites and hormones between vascular and neural compartments. Here, we review the current understanding of BBB development with regard to microphysiology of the neurovascular unit (...
Salmonella risks due to consumption of aquaculture-produced shrimp (JOURNAL)
The use of aquaculture is increasing to meet the growing global demand for seafood. However, the use of aquaculture for seafood production incurs potential human health risks, especially from enteric bacteria such as Salmonella spp. Salmonella spp. was the most frequently reporte...
Modeling Rabbit Responses to Single and Multiple Aerosol Exposures of Bacillus anthracis Spores (HS 4.04.02 - 475) (JOURNAL)
Journal Article
Points of Attention in Designing Tools for Regional Brownfield Prioritization (JOURNAL)
Abstract: This contribution discusses how to develop and run tools to support the prioritization of brownfield investments or actions on a regional scale - an important level of land-use management, where, however, we find hardly available tool support to decision makers to steer...
Representing the process of inflammation as key events in adverse outcome pathways (JOURNAL)
The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...
Connectivity: what is it and why do we care? (JOURNAL)
Being “connected” is an essential component of human health. Connections between people allow for communication, trade and other critical social interactions. Similarly, connections are important for the ecosystems that make up our environment. While “aquatic co...
Investigating the Role of Biofilms in Trihalomethane Formation in Water Distribution Systems with a Multicomponent Model (JOURNAL)
Biofilms ubiquitously exist in the pipes of drinking water distribution systems (DWDSs). Their role in the formation and fate of halogenated disinfection by-products (DBPs) is largely unknown. Recent experimental studies revealed that the chlorination of the microbial biomass car...
Evaluation of Exposure to Brevundimonas diminuta and Pseudomonas aeruginosa during Showering [HS7.44.02] (JOURNAL)
Journal Article
Modeling NH4NO3 Over the San Joaquin Valley During the 2013 DISCOVER‐AQ Campaign (JOURNAL)
The San Joaquin Valley (SJV) of California experiences high concentrations of particulate matter NH4NO3 during episodes of meteorological stagnation in winter. A rich data set of observations related to NH4NO3 formation was acquired during multiple periods of elevated NH4NO3 duri...
Spatio-temporal dynamics of inherent optical properties in oligotrophic northern Gulf of Mexico estuaries (JOURNAL)
Coastal and estuarine ecosystems provide numerous economic and environmental benefits to society. However, increasing anthropogenic activities and developmental pressure may stress these areas and hamper their ecosystem services. Satellite remote sensing could be used as a tool f...
Characterization of River Networks: A GIS Approach and Its Applications (JOURNAL)
Fluvial geomorphology provides the basis for characterizing complex river networks and evaluating biophysical processes within watersheds. Understanding the spatial organization of morphological features, their influencing processes, and resultant geomorphic diversity in stream n...
The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products (JOURNAL)
Quantitative data on product chemical composition is a necessary parameter for characterizing near-field exposure. This data set comprises reported and predicted information on more than 75,000 chemicals and more than 15,000 consumer products. The data’s primary intended us...
Assessing threats of non-native species to native freshwater biodiversity: Conservation priorities for the United States (JOURNAL)
Non-native species pose one of the greatest threats to native biodiversity, and can have severe negative impacts in freshwater ecosystems. Identifying regions of spatial overlap between high freshwater biodiversity and high invasion pressure may thus better inform the prioritizat...