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Objective: To determine if there was a significant difference between mold contamination and asthma prevalence in Detroit and non-Detroit Michigan homes, between newer and older homes, and if there is a correlation between mold contamination and measures of Medicaid use for asthm...

Air pollution continues to exact a substantial public health burden despite considerable improvements in air quality. Many questions remain regarding the toxicity of specific sources of air pollution and associated chemical components, the basis for disproportionate risk among su...

In this poster, consistency across study results is examined via forest plots stratifying by population, exposure (low vs high), overall study confidence, and specific domain ratings. Although the effect estimates vary considerably, when the effect estimates are stratified by exp...

This poster presents analyses of study results for current asthma and pulmonary function endpoints performed as part of a systematic evaluation of the literature database on studies examining the potential for respiratory and immune-mediated conditions in relation to formaldehyde...

Allergic diseases (atopy) include asthma, allergic rhinitis, conjunctivitis, and allergic sinusitis. It is estimated that up to 90% of asthmatics are atopic and have an allergy trigger for asthmatic episodes. In order to assess the risk of allergy induction associated with inhala...

The essential role that early life events (i.e., intrauterine growth restriction) and environmental exposures (i.e., air pollution) play in development of childhood asthma and obesity are only partly understood. Notably, asthmatic children who develop obesity through adolescence ...

Background: Asthma is among the most common chronic diseases of children in the United States (US). Mold exposures have been linked to asthma development and exacerbation. In homes, mold exposures have been quantified using the Environmental Relative Moldiness Index (ERMI) and hi...

Asthma and allergic rhinitis result from the interplay of genetic determinants and exposure to inhaled environmental triggers. While the respiratory impacts of allergic airways disease have been well-studied, the burden on the cardiovascular system has received comparatively litt...

Animal models support validation of high-throughput in vitro assessments of hazardous air pollutants (HAPs) and other methodologically challenging chemicals. Acrolein (ACR) and trichloroethylene (TCE) are EPA high priority HAPs which may exacerbate respiratory symptoms in suscept...

Asthma control depends on many factors, including access and adherence to medications and exposure to asthma triggers. Studies of inner-city children with asthma report that exacerbations decrease when household allergen exposure is reduced1 or with aggressive National Asthma Edu...

Background: The release of catecholamines is preceded by glucocorticoids during a stress response. We have shown that ozone-induced pulmonary responses are mediated through the activation of stress hormone receptors. Objective: To examine the interdependence of beta-adrenergic (&...

The assessment of environmental exposures for human health is an advancing field, characterized by multiple new methodologic and analytic approaches. The difficulties in examining the many broad-based factors impacting human health outcomes are increasingly recognized, with expos...

The Environmental Relative Moldiness Index (ERMI) is a scale created to compare mold contamination levels in U.S. homes. The ERMI was developed as a result of the Department of Housing and Urban Development's (HUD) first American Healthy Homes Survey (AHHS I), which sampled 1,096...

Chronic obstructive pulmonary disease (COPD) is a frequent diagnosis in older individuals and contributor to global morbidity and mortality. Given the link between lung disease and aging, we need to understand how molecular indicators of aging relate to lung function and disease....

The lung is continuously exposed to blood through microvasculature and to ambient contaminants through respiration, making it a· susceptible target for developing injury and chronic diseases. The accessibility of exhaled breath, sputum, nasal and lung lavage fluid, along with tra...

This final report provides the U.S. EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of gaseous oxides of nitrogen. It provides a critical part of the scientific foundation for the U.S. EPA’s decision regarding the adequacy of the c...

The <em>Integrated Science Assessment for Sulfur Oxides – Health Criteria</em> is a concise synthesis and evaluation of the most policy-relevant science, and has been prepared as part of the review of the primary (health-based) National Ambient Air Quality Standards (NAAQS) for S...

EPA announced the availability of the first external review draft of the <em>Integrated Science Assessment for Sulfur Oxides– Health Criteria</em> for public comment and independent peer review in a November 24, 2015 Federal Register Notice. This draft document provides EPA’s ev...

Experiments testing the toxicity of chemical exposures in pregnancy typically use nulliparous rodents or rabbits of optimum age and health, of very similar if not identical genotype, that are fed optimum diets and housed in carefully controlled environments. Clearly, this does m...

In 1992, the EPA completed its risk assessment on <em>The Respiratory Health Effects of Passive Smoking: Lung Cancer and Other Disorders</em> and concluded that the widespread exposure to ETS in the United States presents a serious and substantial public health impact.<br><br>Mor...

This article defines the land cover classes used in Meter-scale Urban Land Cover (MULC), a unique, high resolution (one meter2 per pixel) land cover dataset developed for 30 US communities for the US Environmental Protection Agency EnviroAtlas. MULC data categorize the landscape ...

Air quality is a pressing issue in the urban environment contributing significantly to the global burden of disease [1]. Traffic-related air pollution (TRAP) is a mix of chemicals produced from the burning of diesel and gasoline in vehicles including particulate matter (PM), oxi...

Agonists of β2 adrenergic receptors (β2AR) and glucocorticoid receptors (GR) are prescribed to treat pulmonary diseases. Since ozone effects are mediated through the activation of AR and GR, we hypothesized that the treatment of rats with relevant therapeutic doses of long acting...

Upon completing this course, you will be able to do the following: &bull; Identify why wildfire smoke exposure is a public health and clinical concern. &bull; Identify groups at greatest risk from particle pollution in wildfire smoke. &bull; Explain how particle pollution from wi...

The presentation describes the public health impact of wildland fire smoke exposures, the strategies to minimize risk, and knowledge gaps that when filled, will help health officials better protect the public during wildland fires. The presentation highlights resources available ...