EPA Science Inventory

Asthma Research Products in the Science Inventory

Records 1 to 25 of 533 records about 'asthma'

Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria (Final) (PUBLISHED REPORT)
The final report of the <em>Integrated Science Assessment for Sulfur Oxides– Health Criteria</em> is now available. This report provides EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of sulfur oxides and provides a critical part ...
Impacts of oak pollen on allergic asthma in the United States and potential influence of future climate change (JOURNAL)
Oak pollen season length for moderate (RCP4.5) and severe climate change scenarios (RCP8.5) are estimated through 2090 using five climate models and published relationships between temperature, precipitation, and oak pollen season length. We calculated asthma ED visit counts asso...
Lung Function Changes in Mice Sensitized to Ammonium Hexachloroplatinate (JOURNAL)
Occupational exposure to halogenated platinum salts can trigger the development of asthma. The risk to the general population that may result from the use of platinum in catalytic converters and its emerging use as a diesel fuel additive is unclear. To investigate pulmonary respo...
Differential Effects of Particulate Matter Upwind and Downwind of an Urban Freeway in an Allergic Mouse Model (JOURNAL)
Near-road exposure to air pollutants has been associated with decreased lung function and other adverse health effects in susceptible populations. This study was designed to investigate whether different types of near-road particulate matter (PM) contribute to exacerbation of all...
Epigenetic Regulation of Newborns' Imprinted Genes Related to Gestational Growth: Patterning by Parental Race/Ethnicity and Maternal Socioeconomic Status (JOURNAL)
BACKGROUND: Children born to parents with lower income and education are at risk for obesity and later-life risk of common chronic diseases, and epigenetics has been hypothesised to link these associations. However, epigenetic targets are unknown. We focus on a cluster of well­ c...
Asthma as a disruption in iron homeostasis (JOURNAL)
Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and distinctive molecular pathways. With the application of Occam’s razor to ...
Data-driven asthma endotypes defined from blood biomarker and gene expression data (JOURNAL)
The diagnosis and treatment of childhood asthma is complicated by its mechanistically distinct subtypes (endotypes) driven by genetic susceptibility and modulating environmental factors. Clinical biomarkers and blood gene expression were collected from a stratified, cross-section...
Soy Biodiesel Emissions Have Reduced Inflammatory Effects Compared to Diesel Emissions in Healthy and Allergic Mice (JOURNAL)
Toxicity of exhaust from combustion of petroleum diesel (BO), soy-based biodiesel (B100), or a 20% biodiesel/80% petrodiesel mix (B20) was compared in healthy and house dust mite (HDM)-allergic mice. Fuel emissions were diluted to target fine particulate matter (PM2.5) conrentrat...
Factors associated with self-reported health: implications for screening level community-based health and environmental studies (JOURNAL)
BACKGROUND: Advocates for environmental justice, local, state, and national public health officials, exposure scientists, need broad-based heath indices to identify vulnerable communities. Longitudinal studies show that perception of current health status predicts subsequent mort...
Efffect of Aeroallergen Sensitization on Asthma Control in African-American Teens with Persistent Asthma (JOURNAL)
In African-American adolescents with persistent asthma, allergic profile predicted the likelihood of having poorly controlled asthma despite guidelines-directed therapies. Our results suggest that tree and weed pollen sensitization are independent risk factors for poorly controll...
Interaction with Epithelial Cells Modifies Airway Macrophage Response to Ozone (JOURNAL)
The initial innate immune response to ozone (03) in the lung is orchestrated by structural cells, such as epithelial cells, and resident immune cells, such as airway macrophages (Macs). We developed an epithelial cell-Mac coculture model to investigate how epithelial cell-derived...
ACTIVE VS. SEDENTARY LIFESTYLE FROM WEANING TO ADULTHOOD AND SUSCEPTIBILITY TO OZONE IN RATS (JOURNAL)
This is publication for a peer review journal.
Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria (Second External Review Draft, Dec 2016) (ASSESSMENT DOCUMENT)
This draft document provides EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of sulfur oxides. When final, it will provide a critical part of the scientific foundation for EPA’s decision regarding the adequacy of the current primar...
A Literature Review and Data Mining Project to Identify Associations between Stressors and Health Outcomes for Children (PRESENTATION)
Children are often more vulnerable than adults to the effects of environmental contaminants found in their everyday environments. Their dynamic growth and unique interactions with the built, natural, and social environments may result in a greater susceptibility to chemical and n...
PUBLIC COMMENT ON THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2018 FEDERAL PHYSICAL ACITIVTY GUIDELINES (PRESENTATION)
Title: Public Comment on Department of Health and Human Services (DHHS) 2018 Physical Activity Guidelines Author: Wayne E. Cascio, Director, Environmental Public Health Division, US EPA Abstract: In the 2008 Physical Activity Guidelines, the effects of air pollution and advers...
Studies on the Deposition, Clearance and Toxicity of Combustion Emissions (PRESENTATION)
Seminar on the health impacts of diesel exhaust and biomass combustion emissions
Wildfire smoke exposure and cardiopulmonary hospitalizations among those over age 65 in the United States (PRESENTATION)
Background: The health implications of excess PM2.5 due to wildland fire smoke are not well understood. Very few studies have assessed the effect of wildland fire smoke from multiple fires across the US. Methods: We estimated daily concentrations of PM2.5 due to wildland fire smo...
An EPA pilot study characterizing fungal and bacterial populations at homes after flooding events at the Martin Peña Channel community-Puerto Rico (PRESENTATION)
The overall objective of this program is to characterize fungal and bacterial populations in the MPC residences in San Juan, Puerto Rico, following flooding events. These profiles will be generated by comparing the fungal and bacterial populations in two groups of residences: hom...
A Collaborative Effort to Assess Environmental Health in Newport News, Virginia (PUBLISHED REPORT)
The Region 3 &ldquo;Making a Visible Difference in Communities&rdquo; (MVD) initiative for Southeast Newport News, VA has taken a community-centric, place-based approach to identifying and delivering service to the area&rsquo;s residents and the city as a whole. Beginning with a ...
Community vulnerability to health impacts of wildland fire smoke exposure (JOURNAL)
Identifying communities vulnerable to adverse health effects from exposure to wildfire smoke may help prepare responses, increase the resilience to smoke and improve public health outcomes during smoke days. We developed a Community Health-Vulnerability Index (CHVI) based on fact...
Assessing the impact of fine particulate matter (PM2.5) on respiratory-cardiovascular chronic diseases in the New York City Metropolitan area using Hierarchical Bayesian Model estimates (JOURNAL)
An enhanced research paradigm is presented to address the spatial and temporal gaps in fine particulate matter (PM2.5) measurements and generate realistic and representative concentration fields for use in epidemiological studies of human exposure to ambient air particulate conce...
Effects of Source-Apportioned Coarse Particulate Matter (PM) on Allergic Responses in Mice (PRESENTATION)
The Cleveland Multiple Air Pollutant Study (CMAPS) is one of the first comprehensive studies conducted to evaluate particulate matter (PM) over local and regional scales. Cleveland and the nearby Ohio River Valley impart significant regional sources of air pollution including coa...
Effects of Isoprene- and Toluene-Generated Smog on Allergic Inflammation in Mice (PRESENTATION)
Reactions of organic compounds with nitric oxide (NO) and sunlight produce complex mixtures of pollutants including secondary organic aerosol (SOA), ozone (O3), nitrogen dioxide (NO2), and reactive aldehydes. The health effects of these photochemical smog mixtures in susceptible ...
Use of Medicaid and housing data may help target areas of high asthma prevalence (JOURNAL)
Objective: To determine if there was a significant difference between mold contamination and asthma prevalence in Detroit and non-Detroit Michigan homes, between newer and older homes, and if there is a correlation between mold contamination and measures of Medicaid use for asthm...
Air Pollution Exposure Modeling for Health Studies (PRESENTATION)
Dr. Michael Breen is leading the development of air pollution exposure models, integrated with novel personal sensor technologies, to improve exposure and risk assessments for individuals in health studies. He is co-investigator for multiple health studies assessing the exposure ...