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Background: Prescribed fires often have ecological benefits, but their environmental health risks have been infrequently studied. We investigated associations between residing near a prescribed fire, wildfire smoke exposure, and heart failure (HF) patients' hospital utilizat...

Background: The U.S. Federal Government has supported the generation of extensive amounts of nanomaterials and related nano Environmental Health and Safety (nanoEHS) data, there is a need to make these data available to stakeholders. With recent efforts, a need for improved inter...

Platform presentation at the 41st Veterinary Comparative Respiratory Society meeting on Lung Damage and Repair, Providence RI Oct. 23-25, 2023 October is Children’s Health Month. As a vulnerable population, children are often more susceptible to the damaging effects of poll...

Neurodevelopment is a period vulnerable to various insults, including those produced by environmental compounds, and an understanding of these effects continues to be needed. Although in vitro New Approach Methodologies (NAMs) are being developed to foster efficient assessment of...

The six PFAS we have studied (PFOA, GenX, PFMOAA, PFOS, NBP2, PFHxS) produced multiple common effects across all compounds, however the compounds were not toxicologically identical.  Effects common across all compounds included reduced pup and maternal bodyweights, reduced p...

The Road From Animal Models to New Approach Methods for Protecting Human and Animal Health   Barbara L. F. Kaplan1, Alan M. Hoberman2, William Slikker Jr3, Mary Alice Smith4, Emanuela Corsini5, Thomas B. Knudsen6, M. Sue Marty7, Sonya K. Sobrian8, Suzanne C. Fitzpatrick9, Ma...

Histone deacetylase inhibitors (HDACi) are epigenotoxicants that disrupt gene expression by modulating histone acetylation. We developed a transcriptomic biomarker of HDACi in human TK6 cells to address the limitations in tools available for identifying HDACi in chemical screenin...

Large scale (i.e. continental United States) aquatic resource surveys often collect samples and ship to a centralized processing laboratory. The rigors and chosen methods of shipping and handling as well as holding time could impact the integrity of algal pigments. This study exa...

In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the ...

Poly- and perfluoroalkyl substances (PFAS) are a large class of halogenated organic compounds (HOCs, also called organohalogens) utilized in a variety of industrial applications. Despite their widespread use in bulk quantities, significant concerns have been raised regarding thei...

Halogenated organic compounds (HOCs) are long-lived toxic compounds and are of major concern for ecosystem and health. The use and manufacture of several HOCs is banned or phased out in most countries, but some HOCs are still being used in several countries. The levels of certain...

In this LifeNet Health webinar, Dr. Deisenroth introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. He will discuss the US EPA Endocrine Disruptor Screening Program’...

Introduction The Integrated Risk Information System (IRIS) assessment for trichloroethylene (TCE) found that human data were sufficient to support dose-response modeling and to develop an inhalation unit risk (IUR) for renal cell carcinoma (RCC). However, human and rodent data su...

Within the field of health risk assessment, it is essential that evaluations of reliability or validity of toxicity data are conducted with structure and transparency. To this end, different tools for evaluating toxicity studies have been developed by different groups and organiz...

The Adverse Outcome Pathway (AOP) framework has been adopted as means to assemble, organize, and integrate all available biological information to support sound regulatory decision making. Environmental chemicals can interfere with the thyroid system at numerous sites, and these ...

Iron determines the abundance and diversity of life and controls primary production in numerous aqueous environments. Over the past decades, the availability of this metal in natural waters has decreased. Iron deficiency can apply a selective pressure on microbial aquatic communi...

This Subproduct is a slide deck for an invited presentation at the Georgetown University Center for PFAS and Cancer (CPAC) Joint Virtual Symposium.  Slide deck presents the results of our group's PFAS developmental toxicity mixture studies.  This work demonstrates the d...

Presentation for PIC 2024 meeting 74% of U.S. firefighters are reproductive age (20 – 49 y.o.; 2019) • 92% of U.S. firefighters are male (2019) • A decrease from 99% in the 1980s (Perroni et al. 2021, PLoS One) • Male reproductive tract may be particularly se...

Introduction: Studies of gastrointestinal physiology and the gut microbiome often consider the influence of intestinal region on experimental endpoints. However, this same consideration is not often applied to the gut metabolome. Understanding the contribution of gut regionality...

The Health and Environmental Sciences Institute Developmental and Reproductive Toxicology (HESI-DART) group held a hybrid in-person and virtual workshop in Washington, DC, in 2022. The workshop was entitled, "Interpretation of DART in Regulatory Contexts and Frameworks.&quot...

In March 2021, EPA released the <em>Systematic Review Protocol for the Inorganic Mercury Salts IRIS Assessment (Preliminary Assessment Materials)</em>. As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a ch...

The U.S. Environmental Protection Agency’s (U.S. EPA) Office of Research and Development (ORD) recognized the need to develop an approach to study non-chemical stressors within a chemical stressor paradigm. Research is needed to identify which non-chemical stressors are likely to...

Microplastics are ubiquitous in the environment and present potential adverse effects on human and environmental health. EPA's Office of Research and Development is interested in developing sampling and analytical methods for microplastic detection, investigating their effects on...

The Small Communities - Big Challenges Competition was a ORD and OEJECR sponsored Challenge and Prize Competition that was open to local governments to highlight innovative and inclusive strategies for engaging with rural communities and collaboratively identifying environmental ...

Connectivity mapping is a powerful approach for relating chemicals, targets, and diseases using transcriptomic data (Lamb 2007). It assumes that transcriptomic profiles can fingerprint biological states (e.g., target activation, pathway perturbation, etc.) using the universal lan...