EPA Science Inventory

Records 1 to 11 of 11

2018
Quantitative meta-analytic approaches for the analysis of animal toxicology and epidemiologic data in human health risk assessments (PRESENTATION)
Often, human health risk assessments have relied on qualitative approaches for hazard identification to integrate evidence across multiple studies to conclude whether particular hazards exist. However, quantitative approaches for evidence integration, including the application o...
2017
Comparison of soil sampling and analytical methods for asbestos at the Sumas Mountain Asbestos Site—Working towards a toolbox for better assessment (JOURNAL)
Established soil sampling methods for asbestos are inadequate to support risk assessment and risk-based decision making at Superfund sites due to difficulties in detecting asbestos at low concentrations and difficulty in extrapolating soil concentrations to air concentrations. En...
Finalizing the Libby Action Plan Research Program (PRESENTATION)
Libby, Montana is the location of a former vermiculite mine that operated from 1923 to 1990. The vermiculite ore from the mine co-existed with amphibole asbestos, referred to as Libby Amphibole Asbestos (LAA). Combined with the cessation of the asbestos mining and processing oper...
People, Planet and Profit: Unintended Consequences of Legacy Building Materials (JOURNAL)
Although an explosion of new building materials are being introduced into today's market, adequate up-front research into their chemical and physical properties as well as their potential health and environmental consequences is lacking. History has provided us with several exam...
2016
Consensus Report of the 2015 Weinman International Conference on Mesothelioma (JOURNAL)
On November 9 and 10, 2015, the International Conference on Mesothelioma in Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of Hawaii Cancer Center in Honolulu, Hawaii. The meeting was cosponsored by the International Association for the S...
Quantitative structure - mesothelioma potency model optimization for complex mixtures of elongated particles in rat pleura: A retrospective study (JOURNAL)
Cancer potencies of mineral and synthetic elongated particle (EP) mixtures, including asbestos fibers, are influenced by changes in fiber dose composition, bioavailability, and biodurability in combination with relevant cytotoxic dose-response relationships. A unique and compreh...
The biological effect of asbestos exposure is dependent on changes in iron homeostasis (JOURNAL)
Abstract Functional groups on the surface of fibrous silicates can complex iron. We tested the postulate that 1) asbestos complexes and sequesters host cell iron resulting in a disruption of metal homeostasis and 2) this loss of essential metal results in an oxidative stress and...
2014
IRIS Toxicological Review of Libby Amphibole Asbestos (Final Report) (IRIS ASSESSMENT)
EPA has finalized the, <em>Toxicological Review of Libby Amphibole Asbestos: in support of the Integrated Risk Information System (IRIS)</em>. Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.
2002
Airborne Asbestos Health Assessment Update (Project Summary, 1991) ()
Recent data from population studies strengthened the association of asbestos with disease. Lung cancer and mesothelioma are the most important asbestos-related causes of death. The data suggest that the excess risk of lung cancer from asbestos exposure is proportional to cumulati...
Drinking Water Criteria Document for Asbestos (Final Draft, 1984) ()
No abstract available.
Exposure and Human Health Evaluation of Airborne Pollution from the World Trade Center Disaster (JOURNAL)
In the days following the September 11, 2001, terrorist attack on New York City's World Trade Center (WTC) towers, many Federal agencies, including the U.S. Environmental Protection Agency (EPA), were called upon to bring their technical and scientific expertise to the national e...