EPA Science Inventory

Records 1 to 13 of 13

2017
Comparison of soil sampling and analytical methods for asbestos at the Sumas Mountain Asbestos Site—Working towards a toolbox for better assessment (JOURNAL)
Established soil sampling methods for asbestos are inadequate to support risk assessment and risk-based decision making at Superfund sites due to difficulties in detecting asbestos at low concentrations and difficulty in extrapolating soil concentrations to air concentrations. En...
Finalizing the Libby Action Plan Research Program (PRESENTATION)
Libby, Montana is the location of a former vermiculite mine that operated from 1923 to 1990. The vermiculite ore from the mine co-existed with amphibole asbestos, referred to as Libby Amphibole Asbestos (LAA). Combined with the cessation of the asbestos mining and processing oper...
2016
Consensus Report of the 2015 Weinman International Conference on Mesothelioma (JOURNAL)
On November 9 and 10, 2015, the International Conference on Mesothelioma in Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of Hawaii Cancer Center in Honolulu, Hawaii. The meeting was cosponsored by the International Association for the S...
Long-Term Toxicity of Naturally Occurring Asbestos in Male Fischer 344 Rats (JOURNAL)
Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals. The toxicities of Libby amphibole and NOA samples including Sumas Mountain chrysot...
Persistent Effects of Libby Amphibole and Amosite Asbestos Following Subchronic Inhalation in Rats (JOURNAL)
Background: Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time course effects of LA and positive control amosite (AM) asbestos fibers in male F344 rats following...
Persistent increases in inflammatory cytokines, Akt, and MAPK/ERK pathways after inhalation exposure of rats to Libby amphibole (LA) or amosite: comparison to effects after intratracheal exposure to LA or naturally occurring asbestos. (PRESENTATION)
Human exposure to LA and other mined or processed asbestos increases risk of lung inflammation, fibrosis, and cancer. Health risks from exposure to naturally occurring asbestos (NOA) are not as well-understood. Mechanisms of long-term toxicity were compared in male F344 rats expo...
Quantitative structure - mesothelioma potency model optimization for complex mixtures of elongated particles in rat pleura: A retrospective study (JOURNAL)
Cancer potencies of mineral and synthetic elongated particle (EP) mixtures, including asbestos fibers, are influenced by changes in fiber dose composition, bioavailability, and biodurability in combination with relevant cytotoxic dose-response relationships. A unique and compreh...
The biological effect of asbestos exposure is dependent on changes in iron homeostasis (JOURNAL)
Abstract Functional groups on the surface of fibrous silicates can complex iron. We tested the postulate that 1) asbestos complexes and sequesters host cell iron resulting in a disruption of metal homeostasis and 2) this loss of essential metal results in an oxidative stress and...
2015
Comparative Long-Term Toxicity of Libby Amphibole and Amosite Asbestos after Single or Multiple Intratracheal Exposures (JOURNAL)
In former mine workers of Libby, Montana, exposure to amphibole-containing vermiculite has been linked to increased rates of asbestosis, lung cancer, and mesothelioma. Although many studies have shown adverse effects of Libby Amphibole (LA) exposure, little is known regarding th...
In Vitro Dissolution of Libby Amphibole, Amosite Asbestos, and MMVF Using Acid and Synthetic Lung Fluid Media. (PRESENTATION)
Toxicity of inhaled fibers is dependent in part on biopersistence due to changes in size distribution after deposition and clearance in the respiratory tract. To model this in vivo behavior, respirable (PM2.5) Libby amphibole (LA) and amosite asbestos, and a reference material gl...
Mineral Fiber Toxicology (PRESENTATION)
The chemical and physical properties of different forms of mineral fibers impact biopersistence and pathology in the lung. Fiber chemistry, length, aspect ratio, surface area and dose are critical factors determining mineral fiber-associated health effects including cancer and as...
2014
IRIS Toxicological Review of Libby Amphibole Asbestos (Final Report) (IRIS ASSESSMENT)
EPA has finalized the, <em>Toxicological Review of Libby Amphibole Asbestos: in support of the Integrated Risk Information System (IRIS)</em>. Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.
2002
Exposure and Human Health Evaluation of Airborne Pollution from the World Trade Center Disaster (JOURNAL)
In the days following the September 11, 2001, terrorist attack on New York City's World Trade Center (WTC) towers, many Federal agencies, including the U.S. Environmental Protection Agency (EPA), were called upon to bring their technical and scientific expertise to the national e...