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Records 1 to
25
of 95 records from author Steven Simmons
2024
Martos, S., S. Simmons, AND K. Slentz-Kesler. A New Approach Method for T Cell Immunotoxicity Using CD3/CD28 Co-stimulation and IL-2 NanoLuc Luciferase Reporter. Presented at SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25533373
Sadrpour, P., S. Lynn, R. Judson, AND S. Simmons. Evaluation of Alternative Estrogen Activity Assays for New Computational Models to Support the Endocrine Disruption Screening Program. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25556079
Simmons, S., D. Hallinger, AND E. Brown. High-throughput Identification of Androgen Disrupting ToxCast Chemicals and CYP450 Metabolites. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25545850
Sakamuru, S., J. Travers, C. Klumpp-Thomas, R. Huang, K. Witt, S. Ferguson, S. Simmons, A. Simeonov, AND M. Xia. Profiling the Tox21 Library Compounds for Cytochrome P450 Inhibitory Activity. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25556127
2023
Winters, B., P. Clapp, S. Simmons, T. Kochar, I. Jaspers, AND M. Madden. E-Cigarette Liquids and Aldehyde Flavoring Agents Inhibit CYP2A6 Activity in Lung Epithelial Cells. ACS Omega. American Chemical Society, Washington, DC, 8(12):11261-11266, (2023). https://doi.org/10.1021/acsomega.2c08258
Patlewicz, G., K. Friedman, K. Houck, L. Zhang, R. Huang, M. Xia, J. Brown, AND S. Simmons. Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 26:100271, (2023). https://doi.org/10.1016/j.comtox.2023.100271
Brown, E., D. Hallinger, AND S. Simmons. High-throughput AR Dimerization Assay Identifies Androgen Disrupting Chemicals and Metabolites. Frontiers in Toxicology. Frontiers, Lausanne, Switzerland, 5:1134783, (2023). https://doi.org/10.3389/ftox.2023.1134783
Pennington, E., S. Masood, S. Simmons, L. Dailey, P. Bromberg, R. Rice, A. Gold, Z. Zhang, W. Wu, Y. Yang, AND J. Samet. Real-Time Redox Adaptations in Human Airway Epithelial Cells Exposed to Isoprene Hydroxy Hydroperoxide. Redox Biology. Elsevier B.V., Amsterdam, Netherlands, 61(102646):1, (2023). https://doi.org/10.1016/j.redox.2023.102646
2022
Brown, Evan C., D. Hallinger, AND Steve Simmons. Identifying Androgen Disrupting Chemical Metabolites using Intracellular Xenobiotic mRNA Transfection Method. North Carolina Endocrine Disruptor Conference, Raleigh, NC, September 30, 2022. https://doi.org/10.23645/epacomptox.21493371
Masood, S., E. Pennington, S. Simmons, P. Bromberg, S. Shaikh, R. Rice, A. Gold, Z. Zhang, AND J. Samet. Live cell imaging of oxidative stress in human airway epithelial cells exposed to isoprene hydroxyhydroperoxide. Redox Biology. Elsevier B.V., Amsterdam, Netherlands, 51:102281, (2022). https://doi.org/10.1016/j.redox.2022.102281
Martin, M., S. Padilla, K. Paul-Friedman, D. Herr, Steve Simmons, J. Hedge, AND T. Shafer. Novel approaches using the microelectrode array to measure network function in larval zebrafish (INA 2022). International Neurotoxicology Association (INA) Meeting 2022, Durham, North Carolina, May 16 - 22, 2022. https://doi.org/10.23645/epacomptox.20135990
2021
Simmons, Steve. Novel Protein-Protein Interaction Assays for Human Androgen and Estrogen Receptors-Metabolic Retrofit of Androgen Receptor Assay with mRNA Transfection. Joint Research Centre (JRC) & US EPA/ORD/CCTE Mini Endocrine Summit, RTP, NC, December 06, 2021. https://doi.org/10.23645/epacomptox.17208260
2020
Simmons, Steve AND L. Scarano. Identification of New Approach Methodologies (NAMs) for Placement on the TSCA 4(h)(2)(C) List: A Proposed NAM Nomination Form. Webinar Series on the Use of New Approach Methodologies (NAMs) in Risk Assessment, CARY, NC, September 30, 2020. https://doi.org/10.23645/epacomptox.13370129
Hallinger, D., H. Lindsay, K. Friedman, D. Suarez, AND S. Simmons. Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(1):175-192, (2020). https://doi.org/10.1093/toxsci/kfaa059
2019
Winters, B., A. Wallace, P. Clapp, J. Pleil, Steve Simmons, M. Madden, AND I. jaspers. E-Cigarette Flavoring Compounds Inhibit the Primary Nicotine-Metabolizing Enzyme in a Novel Cell Culture System. Society of Toxicology Annual Meeting, Baltimore, MD, March 10 - 14, 2019.
Noyes, Pamela, K. Friedman, P. Browne, Jonathan Haselman, M. Gilbert, M. Hornung, Stanley Barone, K. Crofton, S. Laws, T. Stoker, S. Simmons, J. Tietge, AND S. Degitz. Evaluating chemicals for thyroid disruption: opportunities and challenges with in vitro testing and adverse outcome pathway approaches. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 127(9):095001, (2019). https://doi.org/10.1289/EHP5297
Corteselli, E., E. Gibbs-Flournoy, Steve Simmons, P. Bromberg, A. Gold, AND James M. Samet. Long Chain Lipid Hydroperoxides Increase the Glutathione Redox Potential Through Glutathione Peroxidase 4. Biochimica et Biophysica Acta. Elsevier Science Ltd, New York, NY, 1863(5):950-959, (2019). https://doi.org/10.1016/j.bbagen.2019.03.002
Hallinger, D., H. Ryskoski, AND Steve Simmons. Mitochondrial-Disrupting ToxCast Chemicals Inhibiting the Electron Transport Chain. Presented at Society of Toxicology 58th Annual Meeting & ToxExpo, Baltimore, Maryland, March 10 - 14, 2019. https://doi.org/10.23645/epacomptox.7847768
DeGroot, D., R. Thomas, Steve Simmons, AND C. Deisenroth. Retrofit Strategies for the Incorporation of Metabolic Competence into In Vitro Assays. Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 10 - 14, 2019.
Patullo, C., S. Simmons, A. Teal, AND R. Pegram. The roles of glutathione s-transferase theta 1-1 and cytochrome P450 2E1 in the metabolism and genotoxicity of the water disinfection byproduct bromodichloromethane in human urothelial cells. NC SOT, Research Triangle Park, NC, October 07, 2019. https://doi.org/10.23645/epacomptox.22572613
2018
Woolard, E., G. Carswell, Steve Simmons, AND B. Chorley. Establishing a high-throughput, DNA barcode method for assessing CYP-mediated effects on chemical toxicity. SETAC: HTS and Environmental Risk Assessment meeting, Durham, NC, April 16 - 18, 2018.
Woolard, E., G. Carswell, Steve Simmons, AND B. Chorley. Establishing a high-throughput, DNA barcode method for assessing CYP-mediated effects on chemical toxicity. Society for in Vitro Biology, Missouri, St. Louis, June 02 - 06, 2018.
Wang, J., D. Hallinger, A. Murr, A. Buckalew, Steve Simmons, S. Laws, AND T. Stoker. High-Throughput Screening and Quantitative Chemical Ranking for Sodium Iodide Symporter Inhibitors in ToxCast Phase 1 Chemical Library. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 52(9):5417-5426, (2018).
Stoker, T., J. Wang, D. Hallinger, A. Murr, A. Buckalew, Steve Simmons, AND S. Laws. High-throughput screening (HTPS) of ToxCast Phase II chemical library for sodium iodide symporter (NIS) Inhibitors. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
Hornung, M., S. Degitz, J. Olker, Joe Korte, J. Denny, S. Laws, T. Stoker, P. Hartig, M. Cardon, D. Hallinger, A. Murr, A. Buckalew, J. Wang, K. Paul-Friedman, AND Steve Simmons. In vitro chemical screening assays to identify thyroid hormone disruptors. SETAC North America Focused Topic Meeting, Durham, NC, April 16 - 18, 2018.