Science Inventory

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Lambert, J. Advancing the Science of PFAS Mixtures Assessment: Draft Framework for Estimating Noncancer Health Risks Associated with Mixtures of Per- and Polyfluoroalkyl Substances (PFAS). Society of Toxicology Webinar, Cincinnati, OH, January 10, 2024. https://doi.org/10.23645/epacomptox.24977913

Brennan, A., D. Chang, J. Cowden, S. Davidson-Fritz, J. Dean, M. Devito, J. Ford, L. Everett, A. Harrill, S. Hester, M. Hughes, J. Lambert, L. Lizarraga, R. Mezencev, D. Macmillan, G. Patlewicz, Kristina Chialton, R. Thomas, K. Vitense, L. Wehmas, A. Renyer, S. Auerbach, AND W. Casey. EPA Transcriptomic Assessment Product (ETAP) for Perfluoro-3-Methoxypropanoic Acid. U.S. Environmental Protection Agency, Washington, DC, EPA/600/X-24/066, 2024. https://doi.org/10.23645/epacomptox.25352962

Thomas, R. AND J. Lambert. New Additions to Address Important Gaps. SOT, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25408357

Chang, D., J. Cowden, S. Davidson-Fritz, J. Dean, M. Devito, L. Everett, A. Harrill, S. Hester, M. Hughes, J. Lambert, L. Lizarraga, R. Mezencev, G. Patlewicz, R. Thomas, L. Wehmas, K. Vitense, S. Auerbach, W. Casey, R. Sams, S. Hunter, J. Bucher, T. Buckley, P. Egeghy, K. Paul-Friedman, J. Harrill, K. Isaacs, R. Judson, J. Kaiser, S. Masten, F. Parham, D. Petersen, A. Phillips, J. Sobus, Dan Villeneuve, P. White, A. Williams, G. Woodall, AND J. Zhao. Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs). U.S. Environmental Protection Agency, Washington, DC, EPA/600/X-23/084, 2024. https://doi.org/10.23645/epacomptox.25365550

Isaacs, K., T. Wall, K. Paul-Friedman, J. Franzosa, H. Goeden, A. Williams, K. Dionisio, J. Lambert, M. Linnenbrink, A. Singh, J. Wambaugh, A. Bogdan, AND C. Greene. Screening for drinking water contaminants of concern using an automated exposure-focused workflow. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 34:136-147, (2024). https://doi.org/10.1038/s41370-023-00552-y

Brennan, A., D. Chang, J. Cowden, S. Davidson-Fritz, J. Dean, M. Devito, J. Ford, L. Everett, A. Harrill, S. Hester, M. Hughes, J. Lambert, L. Lizarraga, R. Mezencev, D. Macmillan, G. Patlewicz, K. Thayer, R. Thomas, K. Vitense, L. Wehmas, A. Renyer, S. Auerbach, W. Casey, R. Sams, S. Hunter, W. Cascio, K. Holt, S. Jones, R. Subramaniam, G. Rice, J. Bucher, T. Buckley, P. Egeghy, K. Paul-Friedman, J. Harrill, K. Isaacs, R. Judson, J. Kaiser, S. Masten, F. Parham, D. Petersen, A. Phillips, J. Sobus, Dan Villeneuve, P. White, A. Williams, G. Woodall, AND J. Zhao. Standard Methods for Development of EPA Transcriptomic Assessment Products (ETAPs). U.S. Environmental Protection Agency, Washington, DC, EPA/600/X-23/083, 2024. https://doi.org/10.23645/epacomptox.25365496

Lambert, J. Transcriptomic Reference Value (TRV) Derivation and Reporting. BOSC, Virtual, NC, July 11 - 12, 2023. https://doi.org/10.23645/epacomptox.23643330

Lambert, J. Adverse Outcome Pathway ‘Footprinting’: A Novel Approach to the Integration of 21st Century Toxicology Information into Chemical Mixtures Risk Assessment. Toxics. MDPI, Basel, Switzerland, 11(1):37, (2022). https://doi.org/10.3390/toxics11010037

Lambert, J. Practical Application of EPA Mixtures Assessment Methods across a Diverse PFAS Data Landscape. AWMA, Durham, NC, November 08, 2022. https://doi.org/10.23645/epacomptox.21388791

Lambert, J. RapidTox workflows for chemical decision-making. OHHRRAF, Chicago, IL, December 06 - 08, 2022. https://doi.org/10.23645/epacomptox.21643955

Lambert, J. State of the Science on the Health Effects Associated with PFAS Exposure. The Public Health and Water Conference, Cincinnati, Ohio, March 22 - 24, 2022. https://doi.org/10.23645/epacomptox.19330538

Lambert, J., T. Martin, AND A. Williams. An Introduction to the CompTox Chemicals Dashboard and New Proof-of-Concept Applications. US Food and Drug Administration Virtual Webinar, NA, Virtual, January 26, 2021.

Druwe, I., B. Blake, Allen Davis, J. Dean, C. Gibbons, J. Lambert, L. Lizarraga, AND X. Arzuaga. Applying the Key Characteristics Approach for the Quantitative Evaluation of the Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Birth Defects Research and Prevention Annual Meeting (Virtually), NA, Virtual, June 28 - 30, 2021.

Owens, B. AND J. Lambert. Human Health Toxicity Assessment for Perfluorobutane Sulfonic Acid (PFBS; CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420-49-3). PFAS Science Call with ECOS and ASTHO, Virtual, N/A, April 26, 2021.

Lambert, J. Quantitative Integration of NAMs into Regulatory Decision-Making: Current State of the Science. SOT 60th Annual Meeting and ToxExpo Virtual Meeting, N/A, N/A, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14681145

Wall, J., C. Greene, H. Goeden, A. Williams, J. Franzosa, J. Wambaugh, Amar V. Singh, M. Linnenbrink, J. Lambert, AND K. Isaacs. Screening for Contaminants of Concern in Surface Water Using an Automated Exposure-Focused Workflow. Society of Environmental Toxicology and Chemistry (SETAC) Meeting November 2021, Portland (Virtual), Oregon (Virtual), November 14 - 18, 2021. https://doi.org/10.23645/epacomptox.17331743

Williams, A., J. Lambert, K. Thayer, AND J. Dorne. Sourcing data on chemical properties and hazard data from the US-EPA CompTox Chemicals Dashboard: a practical guide for human risk assessment. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 154:106566, (2021). https://doi.org/10.1016/j.envint.2021.106566

Gwinn, M., J. Cowden, J. Lambert, A. Lowit, B. Wetmore, L. Scarano, S. Schappelle, R. Thomas, AND E. Burman. Alternative Toxicity Testing Report to Congress. U.S. Environmental Protection Agency, Washington, DC, 2020. https://doi.org/10.23645/epacomptox.12283958.v4

Lambert, J. Complexity of fetal thyroid hormone economy during gestation: Lessons learned from the assessment of in utero exposure to PFBS. December meeting of the Federal Information Exchange (FIE), NA, Remote Access Only, December 11, 2020. https://doi.org/10.23645/epacomptox.13526315

Friedman, K., M. Gagne, L. Loo, P. Karamertzanis, T. Netzeva, T. Sobanski, J. Franzosa, A. Richard, R. Lougee, A. Gissi, J. Lee, M. Angrish, J. Dorne, S. Foster, K. Raffaele, T. Bahadori, M. Gwinn, J. Lambert, M. Whelan, M. Rasenberg, T. Barton-Maclaren, AND R. Thomas. Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 173(1):202-225, (2020). https://doi.org/10.1093/toxsci/kfz201

Patlewicz, G., A. Richard, A. Williams, C. Grulke, R. Sams, J. Lambert, Pamela Noyes, M. DeVito, R. Hines, M. Strynar, A. GuiseppiElie, AND R. Thomas. A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 127(1):1-12, (2019). https://doi.org/10.1289/EHP4555

Lambert, J. An Integrated Approach to Testing and Assessment of Chemical Mixtures in the Environment: The Advent of Adverse Outcome Pathway Footprinting (ASCCT). American Society for Cellular and Computational Toxicology (ASCCT) annual meeting, Gaithersburg, MD, September 25 - 26, 2019. https://doi.org/10.23645/epacomptox.11342225

Lambert, J. Approaches to Hazard and Dose-Response Assessment of PFAS: PFBS Example. Presented at Office of Environmental Health Hazard Assessment (OEHHA) of Cal EPA Workshop on Read-Across, Oakland, CA, May 02 - 03, 2019. https://doi.org/10.23645/epacomptox.8126891

Lambert, J. Development of a RapidTox Dashboard to inform Risk Assessment. Presented at Society of Toxicology annual meeting, Baltimore, MD, March 10 - 14, 2019. https://doi.org/10.23645/epacomptox.7877720

Lambert, J. U.S. EPA’s Use of Read-Across in Provisional Peer-Reviewed Toxicity Value Assessments. Presented at Office of Environmental Health Hazard Assessment (OEHHA) of Cal EPA Workshop on Read-Across, Oakland, CA, May 02 - 03, 2019. https://doi.org/10.23645/epacomptox.8126810