Science Inventory

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Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS). Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25451677

Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS) (Toxics). Toxics. MDPI, Basel, Switzerland, 12(4):271, (2024). https://doi.org/10.3390/toxics12040271

Truong, K., D. Kapraun, S. Davidson-Fritz, J. Wambaugh, S. Degitz, J. Olker, M. Hornung, R. Judson, AND K. Friedman. In Vitro-In Vivo Extrapolation of Thyroid-Related Endpoints with Higher Throughput Pregnancy PBPK Modeling. Quantitative Systems Pharmacology (QSP) Summit Cambridge 2024, Cambridge, MA, May 01, 2024. https://doi.org/10.23645/epacomptox.25765788

Ankley, G., J. Berninger, E. Maloney, J. Olker, C. Schaupp, Dan Villeneuve, AND C. LaLone. Linking Mechanistic Effects of Pharmaceuticals and Personal Care Products to Ecologically Relevant Outcomes: A Decade of Progress. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 43(3):537-548, (2024). https://doi.org/10.1002/etc.5416

Howard, B., C. Norman, A. Tandon, R. Shah, J. Olker, AND D. Hoff. After Correcting for “Concept Drift,” Deep-Learning Methods Can Now Achieve Human-Level Performance When Predicting Article Exclusion Reasons During ECOTOXicology Knowledgebase Curation. Society of Toxicology (SOT) 62nd Annual Meeting and ToxExpo, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.24749343

Olker, J. Application of Systematic Review (SR) Principles to Ecotoxicity Studies: ECOTOXicology Knowledgebase. Continuing Education Course at Society of Toxicology (SOT) 62nd Annual Meeting and ToxExpo, Nashville, TN, March 18, 2023. https://doi.org/10.23645/epacomptox.21753614

Eytcheson, S., J. Olker, K. Paul-Friedman, M. Hornung, AND S. Degitz. Assessing the Predictive Value of Thyroid In Vitro Screening Assays Through Comparisons to Observed Impacts In Vivo. SETAC North America, Louisville, KY, November 12 - 16, 2023. https://doi.org/10.23645/epacomptox.25114523

Eytcheson, S., J. Olker, K. Friedman, M. Hornung, AND S. Degitz. Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 144:105491, (2023). https://doi.org/10.1016/j.yrtph.2023.105491

Schaupp, C., E. Maloney, K. Mattingly, J. Olker, AND D. Villeneuve. Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 195(2):145-154, (2023). https://doi.org/10.1093/toxsci/kfad072

Schaupp, C., E. Maloney, K. Mattingly, J. Olker, AND D. Villeneuve. Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 195(2):145-154, (2023). https://doi.org/10.1093/toxsci/kfad072

Olker, J., J. Daniel, AND B. Kushiyama. ECOTOXicology Knowledgebase Virtual Training. ECOTOX Training, Durham, NC, February 07, 2023. https://doi.org/10.23645/epacomptox.22041242

Olker, J., A. Banerji, K. Benesh, B. Kinziger, T. Scott, T. Karschnik, J. Frisch, T. Feist, A. Pilli, AND D. Hoff. Evidence Map for Ecological Toxicity of Cyanotoxins using ECOTOXicology Knowledgebase Systematic Protocols. SOT, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.24294973

Degitz, S., J. Olker, J. Denny, P. Degoey, P. Hartig, M. Cardon, S. Eytcheson, Jonathan Haselman, S. Mayasich, AND M. Hornung. In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 95:105762, (2024). https://doi.org/10.1016/j.tiv.2023.105762

Olker, J. AND C. Lalone. Adding Standard Identifiers to ECOTOX (Chemicals, Species) and Linking to CompTox Chemicals Dashboard. U.S. Environmental Protection Agency, Washington, DC, 2022.

Pollesch, N., J. Olker, AND R. Wang. Assessing the Quality of Emergent Adverse Outcome Pathways Using Semantic Analysis. SETAC, Pittsburgh, PA, November 13 - 17, 2022. https://doi.org/10.23645/epacomptox.21466638

Villeneuve, Dan, G. Ankley, J. Hoang, K. Jensen, R. Kutsi, A. Kittelson, M. Ellman, J. Collins, AND J. Olker. Case study in the application of “systematic methods” to adverse outcome pathway development: AOPs relevant to ecological effects of PFAS. EPA Systematic Review Community of Practice, NA, MN, September 13, 2022. https://doi.org/10.23645/epacomptox.21234405

Haselman, Jonathan, J. Olker, P. Kosian, J. Korte, J. Denny, J. Tietge, M. Hornung, AND S. Degitz. Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus Laevis Using Iopanoic Acid. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 187(1):139-149, (2022). https://doi.org/10.1093/toxsci/kfac014

Olker, J., J. Korte, Jonathan Haselman, M. Hornung, AND S. Degitz. Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 249:106227, (2022). https://doi.org/10.1016/j.aquatox.2022.106227

Olker, J. AND D. Hoff. ECOTOX Knowledgebase Output for Study Quality and Data Review Applications. U.S. Environmental Protection Agency, Washington, DC, 2022.

Olker, J., A. Banerji, K. Benesh, B. Kinziger, T. Scott, T. Karschnik, J. Frisch, T. Feist, A. Pilli, AND D. Hoff. Ecological Toxicity of Cyanotoxins: Development of an Evidence Map using ECOTOXicology Knowledgebase Systematic Protocols. Society of Environmental Toxicology and Chemistry (SETAC) North America, Pittsburgh, PA, November 13 - 17, 2022. https://doi.org/10.23645/epacomptox.21424605

Schaupp, C., E. Maloney, J. Olker, AND Dan Villeneuve. Evaluating correlations of ECOTOX and ToxCast data through toxicity benchmark derivation. SETAC North America, Pittsburgh, PA, November 13 - 17, 2022. https://doi.org/10.23645/epacomptox.21561474

Olker, J., C. Elonen, D. Hoff, AND J. Berninger. FY21: ECOTOX Knowledgebase updates, including new chemical data and software functionality. U.S. Environmental Protection Agency, Washington, DC, 2022.

Olker, J. FY22: ECOTOX Knowledgebase Quick Guide. U.S. Environmental Protection Agency, Washington, DC, EPA/600/S-22/218, 2022.

Olker, J. FY22: ECOTOX Knowledgebase User Guide. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-22/217, 2022.

Hoff, D., J. Olker, AND J. Berninger. FY22: ECOTOX Knowledgebase updates, including new chemical data and software functionality. U.S. Environmental Protection Agency, Washington, DC, 2022.