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Records 1 to
25
of 56 records from author Rex Pegram
2021
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. Factors Influencing Prediction of Bromodichloromethane (BDCM) in Exhaled Breath. Society of Toxicology 2021 Virtual Annual Meeting, Virtual, NC, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.17952557
2020
Kenyon, E., C. Eklund, R. Pegram, AND J. Lipscomb. Comparison of In Vivo Derived and Scaled In Vitro Metabolic Rate Constants for Several Volatile Organic Compounds (VOCs). TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 69:105002, (2020). https://doi.org/10.1016/j.tiv.2020.105002
Eklund, C., E. Kenyon, R. Pegram, AND J. Simmons. Liter-Equivalence Extrapolation for Four Trihalomethanes (THMs): What Drink Would It Take to Get the Same Internal Dose? Society of Toxicology, Anaheim, California, March 15 - 19, 2020.
Eklund, C., E. Kenyon, R. Pegram, AND J. Simmons. Liter-Equivalence Extrapolation for Four Trihalomethanes (THMs): What Drink Would It Take to Get the Same Internal Dose? (SOT 2020). Society of Toxicology, Anaheim, California, March 15 - 19, 2020. https://doi.org/10.23645/epacomptox.12551309
2019
Kenyon, E., J. Lipscomb, R. Pegram, BJ George, AND R. Hines. THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2):347-359, (2019). https://doi.org/10.1093/toxsci/kfy236
Patullo, C., S. Simmons, A. Teal, AND R. Pegram. The roles of glutathione s-transferase theta 1-1 and cytochrome P450 2E1 in the metabolism and genotoxicity of the water disinfection byproduct bromodichloromethane in human urothelial cells. NC SOT, Research Triangle Park, NC, October 07, 2019. https://doi.org/10.23645/epacomptox.22572613
2018
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. FACTORS INFLUENCING PREDICTION OF BROMODICHLOROMETHANE (BDCM) IN EXHALED BREATH: FURTHER EVALUATION OF A HUMAN BDCM PBPK MODEL. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
Kenyon, E., R. Pegram, J. Lipscomb, AND R. Hines. Impact of Scaling Factor Variation on Pharmacokinetic Outcomes in Pediatric Populations: a Case Study Using Bromodichloromethane (BDCM). FutureTox IV, Crystal City, VA, November 14 - 16, 2018.
2017
Pegram, R., A. Teal, Steve Simmons, T. Ross, J. Campbell, D. DeMarini, AND B. Chorley. Genotoxicity of Brominated Trihalomethanes in Human Bladder Cells. Gordon Research Conference on Drinking Water Disinfection Byproducts, South Hadley, MA, July 30 - August 04, 2017.
Pegram, R., E. Kenyon, Steve Simmons, D. DeMarini, B. Chorley, A. Teal, AND T. Ross. Molecular Mechanisms by Which Chlorinated Water Causes Bladder Cancer. 48th Annual Meeting of the Environmental Mutagenesis and Genomics Society, Raleigh, North Carolina, September 09 - 13, 2017.
Kenyon, E., C. Eklund, R. Pegram, AND J. Simmons. PBPK-MODEL ESTIMATES OF BROMODICHLOROMETHANE (BDCM) DELIVERY TO THE HUMAN URINARY BLADDER. Gordon Research Conference, Mt Holyoke, Massachusetts, July 30 - August 04, 2017.
Kenyon, E., R. Pegram, AND R. Hines. Scaling Factor Variability and Toxicokinetic Outcomes in Children. Childrens Environmental Health Network Research Conference, Washington, DC, April 05 - 07, 2017.
Kenyon, E., J. Lipscomb, R. Pegram, AND R. Hines. THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT TOXICOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM). Society of Toxicology, Baltimore, Maryland, March 12 - 16, 2017.
2016
Pegram, R., J. Campbell, Steve Simmons, T. Ross, D. DeMarini, AND B. Chorley. BROMINATED TRIHALOMETHANE (BrTHM) TOXICITY IN HUMAN BLADDER CELL LINES. 2016 Society of Toxicology Annual Meeting, New Orleans, LA, March 13 - 17, 2016.
Kenyon, E., T. Leavens, C. Eklund, AND R. Pegram. Development and Application of a Human PBPK Model for Bromodichloromethane (BDCM) to Investigate Impacts of Multi-Route Exposure. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(9):1095-1111, (2015).
Sawyer, M., Marina V. Evans, C. Wilson, L. Beesley, L. Leon, C. Eklund, E. Croom, AND R. Pegram. Development of a Human Physiologically Based Pharmacokinetics (PBPK) Model For Dermal Permeability for Lindane. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, 14(245):pp106-109, (2016).
Regli, S., J. Chen, M. Messner, R. Pegram, Michael Wright, T. Pepping, S. Richardson, AND F. Letkiewicz. Estimating Potential Increased Bladder Cancer Risk Due to Increased Bromide Concentrations in Sources of Disinfected Drinking Waters - slides. Presented at ORSANCO WUAC Committee Meeting, Cincinnati, OH, January 27 - 28, 2016.
Kenyon, E., C. Eklund, J. Simmons, AND R. Pegram. PBPK-MODEL ESTIMATES OF BROMODICHLOROMETHANE (BDCM) DISTRIBUTION IN URINE AND BLADDER TISSUE. Society of Toxicology, New Orleans, LA, March 12 - 17, 2016.
Kenyon, E., C. Eklund, J. Lipscomb, AND R. Pegram. The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM). Toxicology Mechanisms and Methods. Taylor & Francis, Inc., Philadelphia, PA, 26(8):620-626, (2016).
2015
Regli, S., J. Chen, M. Messner, M. Elovitz, F. Letkiewicz, R. Pegram, T. Pepping, S. Richardson, AND Michael Wright. Estimating Potential Increased Bladder Cancer Risk Due to Increased Bromide Concentrations in Sources of Disinfected Drinking Waters. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 49(22):13094-13102, (2015).
Croom, E., Tim Shafer, M. Evans, W. Mundy, C. Eklund, A. Johnstone, C. Mack, AND R. Pegram. Improving In Vitro to In Vivo Extrapolation by Incorporating Toxicokinetic Measurements: A Case Study of Lindane-Induced Neurotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 283(1):9-19, (2015).
2012
KENYON, E. M., R. A. PEGRAM, C. R. EKLUND, AND J. C. LIPSCOMB. COMPARISON OF IN VIVO DERIVED AND SCALED IN VITRO METABOLIC RATE CONSTANTS FOR SOME VOLATILE ORGANIC COMPOUNDS (VOCS). Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
CROOM, E. L., TIM SHAFER, W. R. MUNDY, A. F. JOHNSTONE, C. M. MACK, B. ROBINETTE, R. A. PEGRAM, AND R. A. PEGRAM. Improving in vitro to in vivo extrapolation (IVIVE) by incorporation of toxicokinetic measurements: a case study with lindane induced seizures. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
2011
KENYON, E. M., T. L. Leavens, C. Eklund, AND R. A. PEGRAM. APPLICATION OF A MULTIROUTE HUMAN PBPK MODEL FOR BROMODICHLOROMETHANE (BDCM). Presented at Society of Toxicology (SOT) Annual Meeting, Washington, DC, March 06 - 10, 2011.
Croom, E. L. AND R. A. PEGRAM. MEDIA SERUM LEVELS AND IN VITRO HEPATIC ABSORPTION OF LINDANE. Presented at Society of Toxicology (SOT) Annual Meeting, Washington, DC, March 06 - 10, 2011.