Science Inventory

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Chang, X., C. Tan, D. Allen, S. Bell, P. Brown, L. Browning, P. Ceger, J. Gearhart, P. Hakkinen, S. Kabadi, N. Kleinstreuer, A. Lumen, J. Matheson, A. Paini, H. Pangburn, E. Petersen, E. Reinke, A. Ribeiro, N. Sipes, L. Sweeney, J. Wambaugh, R. Wange, B. Wetmore, AND M. Mumtaz. IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making. Toxics. MDPI, Basel, Switzerland, 10(5):232, (2022). https://doi.org/10.3390/toxics10050232

Lowe, K., Jeffrey Dawson, K. Phillips, J. Minucci, J. Wambaugh, H. Qian, T. Ramanarayanan, P. Egeghy, B. Ingle, R. Brunner, E. Mendez, M. Embry, AND C. Tan. Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 127:105073, (2021). https://doi.org/10.1016/j.yrtph.2021.105073

Tan, C., H. Barton, A. Boobis, R. Brunner, H. Clewell, R. Cope, Jeffrey Dawson, J. Domoradzki, P. Egeghy, P. Gulati, B. Ingle, N. Kleinstreuer, K. Lowe, A. Lowit, E. Mendez, David J Miller, J. Minucci, J. Nguyen, A. Paini, M. Perron, K. Phillips, H. Qian, T. Ramanarayanan, F. Sewell, P. Villanueva, J. Wambaugh, AND M. Embry. Opportunities and challenges related to saturation of toxicokinetic processes: implications for risk evaluation. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 127:105070, (2021). https://doi.org/10.1016/j.yrtph.2021.105070

Clewell, R., J. Leonard, C. Nicolas, J. Cambpell, M. Yoon, A. Efremenko, P. McMullen, M. Andersen, H. Clewell, K. Phillips, AND C. Tan. Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 66:104855, (2020). https://doi.org/10.1016/j.tiv.2020.104855

Tan, C., M. Chan, A. Chukwudebe, J. Domoradzki, J. Fisher, E. Hack, P. Hinderliter, K. Hirasawag, J. Leonard, A. Lumen, A. Paini, H. Qian, P. Ruiz, J. Wambaugh, F. Zhang, AND M. Embry. PBPK model reporting template for chemical risk assessment applications. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 115:104691, (2020). https://doi.org/10.1016/j.yrtph.2020.104691

Paini, A., J. Leonard, E. Joossens, J. Bessems, A. Desalegn, J. Dorne, J. Gosling, M. Heringa, M. Klaric, T. Kliment, N. Kramer, G. Loizou, J. Louisse, A. Lumen, J. Madden, E. Patterson, S. Proença, A. Punt, Woodrow Setzer, N. Suciu, J. Troutman, M. Yoon, A. Worth, AND C. Tan. Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 9:61-72, (2019). https://doi.org/10.1016/j.comtox.2018.11.002

Leonard, J., C. Stevens, K. Mansouri, D. Chang, H. Pudukodu, S. Smith, AND C. Tan. A Workflow for Identifying Metabolically Active Chemicals to Complement in vitro Toxicity Screening. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 6:71-83, (2018).

Tan, C. A tiered approach to incorporate exposure and pharmacokinetics considerations in in vitro based safety assessment. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Tan, C., J. Leonard, S. Edwards, J. Teeguarden, A. Paini, AND P. Egeghy. Aggregate exposure pathways in support of risk assessment. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 9:8-13, (2018).

Worley, R., J. Leonard, J. Fisher, AND C. Tan. Approaches for Increasing Acceptance of Physiologically Based Pharmacokinetic Models in Public Health Risk Assessment. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Tan, C., R. Worley, J. Leonard, AND J. Fisher. Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 162(2):341-348, (2018).

Setzer, Woodrow AND C. Tan. EURL ECVAM WORKSHOP ON NEW GENERATION OF PHYSIOLOGICALLY-BASED KINETIC MODELS IN RISK ASSESSMENT. Publications Office of the European Union, , Luxembourg, 2018. https://doi.org/10.2760/619902

Tan, C., J. Leonard, J. Wambaugh, K. Isaacs, Dan Villeneuve, C. LaLone, S. Edwards, A. Williams, AND Chris Grulke. Free access platforms for integrating environmental chemical exposure and hazard information. EuroTox 2018, Brussels, BELGIUM, September 02 - 05, 2018.

Tan, C. Incorporating toxicokinetic data and tools to support public health decision making. Eurotox 2018, Brussels, BELGIUM, September 02 - 05, 2018.

Leonard, J., H. El-Masri, C. Stevens, K. Mansouri, AND C. Tan. Integrating Exposure, Pharmacokinetics, And Dosimetry With In Vitro Dose-Response Data To Evaluate Chemical Risk. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Chen, S., Y. Sung, E. Oyarzabal, C. Tan, J. Leonard, M. Guo, S. Li, Q. Wang, C. Chu, S. Chen, R. Lu, AND J. Hong. Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway. Molecular Neurobiology. Springer, Heidelburg, Germany, 55(10):8001-8013, (2018). https://doi.org/10.1007/s12035-018-0965-4

Tan, C., J. Leonard, S. Edwards, J. Teeguarden, AND P. Egeghy. Refining the aggregate exposure pathway. Environmental Science: Processes & Impacts. RSC Publishing, Cambridge, Uk, 3(20):428-436, (2018).

Edwards, S., C. Tan, J. Leonard, P. Egeghy, AND J. Teeguarden. A conceptual framework to advance exposure science research and complement the Adverse Outcome Pathway framework. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Leonard, J., D. Chang, H. El-Masri, S. Edwards, C. Stevens, K. Mansouri, P. Egeghy, AND C. Tan. A tiered approach for integrating exposure and dosimetry with in vitro dose-response data in the modern risk assessment paradigm. 254th ACS National Meeting & Exposition, Washington, DC, August 20 - 24, 2017.

Tan, C. Applying Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks to link toxicity testing data to exposure-relevant and biologically-relevant responses. Opentox USA 2017, Durham, NC, July 12 - 13, 2017.

Leonard, J. AND C. Tan. Complementing in vitro hazard assessment with exposure and pharmacokinetics considerations for chemical prioritization. 2017 ISES Annual Meeting, Durham, NC, October 15 - 19, 2017.

Tan, C. Complementing in vitro screening assays with in silico molecular chemistry tools to examine potential in vivo metabolite-mediated effects. 2017 Society of Toxicology Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Grulke, Chris, Rocky Goldsmith, R. Brooks, D. Chang, C. Tan, R. Tornero-Velez, AND K. Holm. Enabling PBPK model development through the application of freely available techniques for the creation of a chemically-annotatedcollection of literature. Presented at American Chemical Society, San Francisco, CA, August 10 - 14, 2014.

Lee, S., C. Tan, M. Phillips, J. Sobus, AND S. Kim. Estimating Methylmercury Intake for the General Population of South Korea Using Physiologically Based Pharmacokinetic Modeling. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 159(1):6-15, (2017).

Tan, C. Frameworks for organizing exposure and toxicity data - the Aggregate Exposure Pathway (AEP) and the Adverse Outcome Pathway (AOP). 2017 ISES Annual Meeting, Durham, NC, October 15 - 19, 2017.