Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 5965 records from ORD about 'Health' published between 08/21/2013 and 08/21/2018

2018
.Network analytics for adverse outcome pathways (PRESENTATION)
Adverse Outcome Pathways (AOPs) organize toxicological knowledge from the molecular level up to the population level, providing evidence-based causal linkages at each step. The AOPWiki serves as a repository of AOPs. With the international adoption of the AOP framework, the AOPw...
2012 Annual Report to Characterize the Ottawa River Using Physical, Biological, and Chemical Lines of Evidence (PUBLISHED REPORT)
International concern about contaminated sediments is increasing as sustainable practices are needed to maintain water resources and waterways as important economic, commercial, recreational, and community resources. Sediments often serve as long-term sinks for legacy pollutants,...
2013 NIEHS/EPA Children's Centers Annual Meeting: Protecting Children's Health for a Lifetime (EPA PUBLISHED PROCEEDINGS)
This report includes proceedings from the 2013 NIEHS/EPA Children's Centers Annual Meeting, held in Washington D.C. in October, 2013. Summaries of presentations, speaker biosketches, poster abstracts, and a meeting participant list are all included.
2015 NIEHS/EPA Children's Centers Annual Meeting Report (EPA PUBLISHED PROCEEDINGS)
The report includes proceedings from the 2015 NIEHS/EPA Children's Centers Annual Meeting. The proceedings include presentation summaries, speaker biosketches, poster abstracts, and a list of meeting participants.
2017 STATE OF NARRAGANSETT BAY AND ITS WATERSHED – MAPPING DRIVERS OF CHANGE AND VARIATION (PRESENTATION)
The Narragansett Bay Estuary Program (NBEP) developed 24 environmental indicators for its 2017 State of Narragansett Bay and Its Watershed report with the collaboration of over 50 bi-state (MA and RI) and regional partners. The report presents and tracks the 24 indicators in ord...
25 Years of Water Quality Change in Rhode Island Lakes and Ponds (PRESENTATION)
The University of Rhode Island’s Watershed Watch Volunteer Monitoring Program has been collecting water quality data on dozens of Rhode Island lakes and ponds for over 25 years, allowing exploration of long-term trends in common water quality parameters. Not all lakes and p...
3D-QSAR Study of Steroidal and Azaheterocyclic Human Aromatase Inhibitors using Quantitative Profile of Protein-Ligand Interactions (JOURNAL)
Aromatase is a member of the cytochrome P450 superfamily responsible for a key step in the biosynthesis of estrogens. As estrogens are involved in the control of important reproduction-related processes, including sexual differentiation and maturation, aromatase is a potential ta...
A 72-HOUR STUDY WITH GRAPHENE OXIDE NANOPARTICLES AND EASTERN OYSTERS (PRESENTATION)
Graphene family nanomaterials (GFNs) are widely used in the field of electronics and biomedicine. Gaps in our knowledge about fate and toxicity of GFNs, such as graphene oxide (GO), raise concerns regarding their environmental impacts. Filter feeding bivalves, such as Crassostrea...
A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA) (JOURNAL)
Cumulative risk assessment (CRA) methods promote the use of a conceptual site model (CSM) to apportion exposures and integrate risk from multiple stressors. While CSMs may encompass multiple species, evaluating end points across taxa can be challenging due to data availability an...
A Cell Model to Evaluate Chemical Effects on Adult Human Cardiac Progenitor Cell Differentiation and Function (PRESENTATION)
Adult cardiac stem cells (CSC) and progenitor cells (CPC) represent a population of cells in the heart critical for its regeneration and function over a lifetime. The impact of chemicals on adult human CSC/CPC differentiation and function is unknown. Research was conducted to dev...
A Chemical Activity Approach to Exposure and Risk Assessment of Chemicals (JOURNAL)
To support the goals articulated in the vision for exposure and risk assessment in the twenty-first century, we highlight the application of a thermodynamic chemical activity approach for the exposure and risk assessment of chemicals in the environment. The present article descri...
A Dose-Response Meta-Analysis of Chronic Arsenic Exposure and Incident Cardiovascular Disease (JOURNAL)
Introduction: High levels of arsenic in drinking water (≥100 µg/L) have consistently been associated with cardiovascular disease (CVD). Growing evidence supports a link with arsenic at low-moderate levels (<100 µg/L). Our objective was to examine the dose-response relationship be...
A Flexible Web-Interface for Integrating Multiple Data Streams in Support of Risk Prioritization of Environmental Chemicals (PRESENTATION)
Detailed chemical risk assessments are time-consuming and difficult to compile, leading to regulatory mandates to prioritize chemicals for further assessment. Multiple regulatory bodies (EPA, ECHA, Health Canada) are currently tasked with prioritizing chemicals for data collecti...
A Floodplain Map of the Conterminous United States Developed Using Random Forest Classification (PRESENTATION)
Floodplains perform several important ecosystem services, including storing water during precipitation events and reducing peak flows, thereby reducing flooding of adjacent communities. Understanding the relationship between flood inundation and floodplains is critical for ecosys...
A Framework for Linking Population Model Development with Ecological Risk Assessment Objectives. (JOURNAL)
The value of models that link organism&#8208;level impacts to the responses of a population in ecological risk assessments (ERAs) has been demonstrated extensively over the past few decades. There is little debate about the utility of these models to translate multiple organism&#...
A Genomic Response to Trace Fear Conditioning in the Amygdala of Female Rats After Developmental Exposure to Manganese (PRESENTATION)
Increases in brain-derived neurotrophic factor (Bdnf), Ca2+/calmodulin-dependent protein kinase II alpha (Camk2a), and cyclic adenosine monophosphate (cAMP) response element binding (Creb1) gene expression have been associated with learning in a variety of different rodent studie...
A High-throughput Analytical Framework for Efficient Analysis of In Vitro Micronucleus (MN) Dose-response Data (PRESENTATION)
Health Canada assesses the health risks posed by chemicals in commerce in Canada. An important endpoint in chemical assessment is genetic toxicity (e.g., ability to damage DNA) which is associated with cancer and inherited genetic diseases. The in vitro micronucleus (MN) assay is...
A Historical Perspective on the Dichotomy of Arsenic as a Poison and Medicinal Agent (PRESENTATION)
Arsenic is one of the most interesting and enigmatic elements of the periodic table. Its use as an intentional poison has been known for centuries and occasionally occurs today. Arsenic has been called the &ldquo;King of Poisons&rdquo;, because it had been used to poison royalt...
A Human Fecal Contamination Score for Ranking Recreational Sites using the HF183/BacR287 Quantitative Real-Time PCR Method (JOURNAL)
Human fecal pollution of recreational waters remains a public health concern worldwide. As a result, there is a growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality research and manag...
A Maieutic Exploration of Nudging Strategies for Regional Climate Applications Using the WRF Model (JOURNAL)
The use of nudging in the Weather Research and Forecasting (WRF) Model to constrain regional climate downscaling simulations is gaining in popularity because it can reduce error and improve consistency with the driving data. While some attention has been paid to whether nudging i...
A Marketing Plan for Scientists: Building Effective Products and Connecting with Stakeholders in Meaningful Ways (JOURNAL)
A disconnect often occurs between the creation of scientific research outputs and their use by intended stakeholders. Even with the diligent efforts of scientists to create products of value, many scientific outputs are underutilized by intended stakeholders. Marketing methods ca...
A Physiologically-Based Pharmacokinetic (PBPK) Model With Metabolic Interactions of Chloroform (CHCL3) and Trichloroethylene (PRESENTATION)
Exposure to mixtures is frequent, but biologic pathways such as metabolic inhibition, are poorly understood. CHCl3 and TCE are model volatiles frequently co-occurring; combined exposure results in less than additive hepatotoxicity. Here, we explore the underlying metabolic inte...
A Proof-of-Concept Approach for Quantifying Multi-Pollutant Health Impacts Using the Open-Source BenMAP-CE Software Program (PRESENTATION)
Background Air pollution risk assessments often employ effect coefficients from epidemiologic studies to quantify the public health impact of changes in air quality. Partly due to data and methodological limitations, epidemiologic studies have traditionally characterized the heal...
A Workflow for Identifying Metabolically Active Chemicals to Complement in vitro Toxicity Screening (JOURNAL)
The new paradigm of toxicity testing approaches involves rapid screening of thousands of chemicals across hundreds of biological targets through use of in vitro assays. Such assays may lead to false negatives when the complex metabolic processes that render a chemical bioactive i...
A case study evaluation of fog simulation using two land-surface (PRESENTATION)
Despite its importance to transportation safety and ecosystem health related to pollutant and nutrient deposition, the simulation of fog lags the simulation of other meteorological phenomena due in large part to its complexity and limitations of model resolution. Accordingly, th...