Next >>

Adverse Outcome Pathways (AOPs) organize toxicological knowledge from the molecular level up to the population level, providing evidence-based causal linkages at each step. The AOPWiki serves as a repository of AOPs. With the international adoption of the AOP framework, the AOPw...

This report includes proceedings from the 2013 NIEHS/EPA Children's Centers Annual Meeting, held in Washington D.C. in October, 2013. Summaries of presentations, speaker biosketches, poster abstracts, and a meeting participant list are all included.

The report includes proceedings from the 2015 NIEHS/EPA Children's Centers Annual Meeting. The proceedings include presentation summaries, speaker biosketches, poster abstracts, and a list of meeting participants.

The University of Rhode Island’s Watershed Watch Volunteer Monitoring Program has been collecting water quality data on dozens of Rhode Island lakes and ponds for over 25 years, allowing exploration of long-term trends in common water quality parameters. Not all lakes and p...

Aromatase is a member of the cytochrome P450 superfamily responsible for a key step in the biosynthesis of estrogens. As estrogens are involved in the control of important reproduction-related processes, including sexual differentiation and maturation, aromatase is a potential ta...

Cells in developing tissues must integrate and respond to highly dynamic information in the form of metabolic intermediates, genetic signals, and molecular gradients. Understanding the cellular decision-making process, and how these decisions may be perturbed by genetic errors or...

Graphene family nanomaterials (GFNs) are widely used in the field of electronics and biomedicine. Gaps in our knowledge about fate and toxicity of GFNs, such as graphene oxide (GO), raise concerns regarding their environmental impacts. Filter feeding bivalves, such as Crassostrea...

Cumulative risk assessment (CRA) methods promote the use of a conceptual site model (CSM) to apportion exposures and integrate risk from multiple stressors. While CSMs may encompass multiple species, evaluating end points across taxa can be challenging due to data availability an...

Adult cardiac stem cells (CSC) and progenitor cells (CPC) represent a population of cells in the heart critical for its regeneration and function over a lifetime. The impact of chemicals on adult human CSC/CPC differentiation and function is unknown. Research was conducted to dev...

To support the goals articulated in the vision for exposure and risk assessment in the twenty-first century, we highlight the application of a thermodynamic chemical activity approach for the exposure and risk assessment of chemicals in the environment. The present article descri...

From the earliest days of public health, environmental protection has been fundamental to preventing disease and ensuring a healthy population. From John Snow and the Broad Street Pump to chlorinated drinking water in Jersey City, NJ, protecting the environment has been a core pu...

Introduction: High levels of arsenic in drinking water (≥100 µg/L) have consistently been associated with cardiovascular disease (CVD). Growing evidence supports a link with arsenic at low-moderate levels (<100 µg/L). Our objective was to examine the dose-response relationship be...

Detailed chemical risk assessments are time-consuming and difficult to compile, leading to regulatory mandates to prioritize chemicals for further assessment. Multiple regulatory bodies (EPA, ECHA, Health Canada) are currently tasked with prioritizing chemicals for data collecti...

The value of models that link organism&#8208;level impacts to the responses of a population in ecological risk assessments (ERAs) has been demonstrated extensively over the past few decades. There is little debate about the utility of these models to translate multiple organism&#...

Increases in brain-derived neurotrophic factor (Bdnf), Ca2+/calmodulin-dependent protein kinase II alpha (Camk2a), and cyclic adenosine monophosphate (cAMP) response element binding (Creb1) gene expression have been associated with learning in a variety of different rodent studie...

Stress tests are used clinically to uncover underlying disease and predict future cardiovascular risk. Previously, we used treadmill exercise stress in rats to reveal latent effects of air pollution inhalation. Other daily stressors, when modeled experimentally, may have similar ...

Health Canada assesses the health risks posed by chemicals in commerce in Canada. An important endpoint in chemical assessment is genetic toxicity (e.g., ability to damage DNA) which is associated with cancer and inherited genetic diseases. The in vitro micronucleus (MN) assay is...

Arsenic is one of the most interesting and enigmatic elements of the periodic table. Its use as an intentional poison has been known for centuries and occasionally occurs today. Arsenic has been called the &ldquo;King of Poisons&rdquo;, because it had been used to poison royalt...

Human fecal pollution of recreational waters remains a public health concern worldwide. As a result, there is a growing interest in the application of human-associated fecal source identification quantitative real-time PCR (qPCR) technologies for water quality research and manag...

A disconnect often occurs between the creation of scientific research outputs and their use by intended stakeholders. Even with the diligent efforts of scientists to create products of value, many scientific outputs are underutilized by intended stakeholders. Marketing methods ca...

Exposure to mixtures is frequent, but biologic pathways such as metabolic inhibition, are poorly understood. CHCl3 and TCE are model volatiles frequently co-occurring; combined exposure results in less than additive hepatotoxicity. Here, we explore the underlying metabolic inte...

Background Air pollution risk assessments often employ effect coefficients from epidemiologic studies to quantify the public health impact of changes in air quality. Partly due to data and methodological limitations, epidemiologic studies have traditionally characterized the heal...

The new paradigm of toxicity testing approaches involves rapid screening of thousands of chemicals across hundreds of biological targets through use of in vitro assays. Such assays may lead to false negatives when the complex metabolic processes that render a chemical bioactive i...

Despite its importance to transportation safety and ecosystem health related to pollutant and nutrient deposition, the simulation of fog lags the simulation of other meteorological phenomena due in large part to its complexity and limitations of model resolution. Accordingly, th...

Ecological risk assessments are often limited in their ability to consider metabolic transformations for fish species due to a lack of data. When these types of evaluations are attempted they are often based on parent chemical only, or by assuming similarity to available mammali...