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The US Environmental Protection Agency (EPA) ToxCast data pipeline (tcpl) has been applied to >1000 assay endpoints as first tier data processing of bioactivity data from high-throughput screening (HTS) stored in the “invitrodb” database. First, tcpl and the structure of invitrod...

To support sound decision-making in environmental management, we need rigorous, defensible, and transparent synthesis of scientific evidence. The Association for the Sciences of Limnology and Oceanography (ASLO) and associated aquatic science societies are leaders in applying sci...

Diesel and biodiesel particulates have been demonstrated to reduced vascular responsiveness in vivo and in vitro, but the components of PM responsible for this effect are poorly understood. Fatty acids represent a significant fraction of the compounds that make up organic combust...

2,4,6-tribromophenol (TBP, CAS No. 118-79-6) is widely used as a brominated flame retardant and wood antifungal agent. TBP is frequently detected in environmental matrices, biota, and humans. In female SD rats, systemically available TBP (10 µmol/kg, IV) was rapidly excrete...

2,4,6-tribromophenol (TBP, CAS No. 118-79-6) is a naturally-occurring bromophenol that is widely used as a brominated flame retardant and wood antifungal. TBP is found in soil, dust, wild-caught seafood, and humans. TBP in vivo studies of oral and dermal disposition were conducte...

The University of Rhode Island’s Watershed Watch Volunteer Monitoring Program has been collecting water quality data on dozens of Rhode Island lakes and ponds for over 25 years, allowing exploration of long-term trends in common water quality parameters. Not all lakes and p...

Graphene is a two-dimensional nanomaterial with unique mechanical, thermal, electrical, and optical properties. With increasing applications of graphene-family nanomaterials (GFNs) in numerous fields such as electronics, biomedicine, and surface coatings, concern for their impact...

Per- and polyfluoroalkyl substances (PFAS) are a group of fluorinated substances of interest to researchers, regulators, and the public due to their widespread presence in the environment. Some PFAS have comparatively extensive amounts of human epidemiological, exposure, and expe...

Chemicals that disrupt androgen receptor function during sexual differentiation in utero induce a cascade of adverse effects on F1 male reproductive development including reduced AGD, retained nipples, agenesis of androgen-dependent organs and reproductive tract malformations. ...

This submission is a slide presentation for a conference on PFAS and emerging contaminants by the American Council of Engineering Companies of North Carolina (ACEC/NC) and the Groundwater Professional of NC (GWPNC). The presentation is a case study in detection and identification...

Populations of cold-water fishes are increasingly faced with warm river temperatures. Cold water refuges (CWR) – areas of cold water in which thermally-stressed individuals may seek temporary shelter – are increasingly invoked as a potentially mitigating feature withi...

The thyroid-stimulating hormone receptor (TSHR) is a G protein-coupled receptor that signals through adenylate cyclase to increase intracellular 3’,5’- cyclic adenosine monophosphate (cAMP), resulting in increased thyroid hormone (TH) production in thyroid follicular cells. Due t...

Early developmental exposure to stress has been reported to influence learning and memory mechanisms. Changes in the gene expression of brain-derived neurotrophic factor (Bdnf), Ca2+/calmodulin-dependent protein kinase II alpha (Camk2a), and cyclic adenosine monophosphate (cAMP)...

Background: Exposure to fine particulate matter (PM2.5), an ambient air pollutant with mass-based standards promulgated under the Clean Air Act, and black carbon (BC), a common component of PM2.5, are both associated with cardiovascular health effects. Objectives: To elucidate wh...

Geographically Isolated Wetlands (GIWs) are unique geological features that provide habitat for endemic, endangered, and threatened animal and plant species and ecosystem services (ES). GIWs are threatened by a range of chemical contaminants that vary by geographic region and ass...

The last decade has seen a proliferation of studies describing the benefits people accrue from natural processes by translation of remotely sensed land use and / or land cover (LULC) data to ecosystem service provision. Yet, critical assessment of systemic errors resulting from r...

Chemicals in the environment can prevent proper reproduction in fish. However, it was unknown whether models developed using data collected from the commonly studied fathead minnow could accurately predict adverse effects to other fish species. Results of our study suggest that t...

Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of nine genome-wide association studies of plasma FVII levels (seven FVII activity and two F...

Mercury (Hg) contamination in the Great Lakes region is a prevalent concern due to elevated Hg concentrations in fish in relation to human health and wildlife guidelines. The lower St. Louis River, the largest tributary to Lake Superior, exhibits fish Hg concentrations twice that...

Environmental stressors and contaminants can lead to Adverse Outcomes (AOs) in both human health and ecological receptors. Evaluating risk of AOs across multiple organisms in a community is crucial to characterize the cumulative impacts of stressors and contaminants; but is chal...

Cortical heterotopias are characterized as clusters of ectopic neurons in the brain, and are associated with neurodevelopmental disorders like epilepsy and learning disabilities in patients. We have previously characterized the robust penetrance of a heterotopia in a rat model, i...

Agricultural best management practices (BMPs) reduce non-point source pollution from cropland. Goals for BMP adoption and expected pollutant load reductions are often specified in water quality management plans to protect and restore waterbodies; however, estimates of needed load...

Background: Epidemiological studies report fairly consistent associations between various air pollution metrics and autism spectrum disorder (ASD), with some elevated risks reported for different prenatal and postnatal periods. Objective: To examine associations between ASD and ...

Purpose: The objectives were to use National Health and Nutrition Examination Survey (NHANES) data to: 1) estimate the prevalence of metabolic syndrome (MetS) risk factors (elevated blood pressure, triglycerides, blood glucose, and low HDL cholesterol); 2) estimate the prevalence...

New approach methodologies (NAMs) play a key role in accelerating the pace of chemical risk assessment, and are an important tool for the future of regulatory decision making. Accelerating the Pace of Chemical Risk Assessment (APCRA) is a government-to-government initiative whos...