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This report includes proceedings from the 2013 NIEHS/EPA Children's Centers Annual Meeting, held in Washington D.C. in October, 2013. Summaries of presentations, speaker biosketches, poster abstracts, and a meeting participant list are all included.

The report includes proceedings from the 2015 NIEHS/EPA Children's Centers Annual Meeting. The proceedings include presentation summaries, speaker biosketches, poster abstracts, and a list of meeting participants.

A high level presentation for their senior people, lasting perhaps 45 minutes, covering a history of the protocol program, outcome focused… the why’s and how’s, and how you measure success.

Vegetative leaf area is a critical input to models that simulate human and ecosystem exposure to atmospheric pollutants. Leaf area index (LAI) can be measured in the field or numerically simulated, but all contain some inherent uncertainty that is passed to the exposure assessmen...

Stress tests are used clinically to uncover underlying disease and predict future cardiovascular risk. Previously, we used treadmill exercise stress in rats to reveal latent effects of air pollution inhalation. Other daily stressors, when modeled experimentally, may have similar ...

Background Air pollution risk assessments often employ effect coefficients from epidemiologic studies to quantify the public health impact of changes in air quality. Partly due to data and methodological limitations, epidemiologic studies have traditionally characterized the heal...

The Adverse Outcome Pathway (AOP) framework represents an ideal tool for integrating diverse data relating chemical exposures to adverse outcomes. Glucocorticoid signaling is tightly controlled and numerous adverse health outcomes have been associated with either elevation or sup...

This is the presentation for the invited lecture at Rutgers University. The lecture will be part of online course titled "Sustainability Decision Tools" in Spring 2018.

Although epidemiological, human and animal data have conclusively linked air pollution exposure to adverse cardiovascular outcomes, the severity of responses depends on a number of intrinsic (diet, underlying disease, etc) and extrinsic (e.g. co-stressors) factors. As such, cardi...

Wildland fires are increasingly linked to adverse health impacts related to poor air quality. For instance, short-term exposure to smoldering peat (SP) air pollution in eastern North Carolina during separate burns in 2008 and 2011 led to increased cardiopulmonary emergency room v...

Recent studies showed that the circulating stress hormones, epinephrine and corticosterone/cortisol, are involved in mediating ozone-induced pulmonary effects through the activation of the sympathetic-adrenal-medullary (SAM) and hypothalamus-pituitary-adrenal (HPA) axes. Hence, w...

This research paper uses case analysis methods to understand why participants engage in this innovative approach public participation in scientific research, and what they hope that will mean for their community. The research questions that guide this analysis are: 1) what factor...

Air pollution epidemiology studies of ambient fine particulate matter (PM2.5) often use outdoor concentrations as exposure surrogates. These surrogates can induce exposure error since they do not account for (1) time spent indoors with ambient PM2.5 levels attenuated from outdoor...

New experimental evidence involving the role of neuroendocrine activation challenges an accepted mechanistic paradigm of how irritant air pollutants induce systemic metabolic impairment and lung injury/inflammation. We focus on recent air pollution studies highlighting how the re...

Air pollution epidemiology studies of ambient fine particulate matter (PM2.5) often use outdoor concentrations as exposure surrogates. These surrogates can induce exposure error since they do not account for (1) time spent indoors with ambient PM2.5 levels attenuated from outdoor...

It is often of interest to model the incidence and duration of threshold exceedance events for an environmental variable over a set of monitoring locations. Such data arrive over continuous time and can be considered as observations of a two-state process yielding, sequentially, ...

Exposure to air pollution-derived particulate matter (PM) causes adverse cardiovascular health outcomes, with increasing evidence implicating soluble components of PM; however, the enormous number of unique PM samples from different air sheds far exceeds the capacity of conventio...

Background: Electronic health records (EHRs) are now a ubiquitous component of the US healthcare system and are attractive for secondary data analysis as they contain detailed and longitudinal clinical records on potentially millions of individuals. However, due to their relative...

Select volatile organic compounds (VOCs) in ambient air were measured at four fenceline sites at a petroleum refinery in Whiting, Indiana, USA using modified EPA Method 325 A/B with passive tubes and EPA Compendium Method TO-15 with canister samplers. One-week, time-integrated s...

Objective: Exposure to mobile source emissions is nearly ubiquitous in developed nations, and is associated with multiple adverse health outcomes. There is an ongoing need to understand the specificity of traffic exposure associations with vascular outcomes, particularly in indi...

As part of the U.S. Environmental Protection Agency’s continuing assessment of advanced light-duty automotive technologies to support the setting of appropriate national greenhouse gas standards, and to evaluate the impact of new technologies on in-use emissions, a 2016 Honda Civ...

In humans and rats, acute exposures to ozone have been shown to activate the sympathetic-adrenal-medullary and hypothalamic-pituitary-adrenal axes to induce multi-organ metabolic alterations including impaired glucose homeostasis. These findings have largely been gleaned from on...

" Exploration into the roles of genes, the proteins that they encode, and the functions that they carry out within the cell is a founding pillar in the field of toxicology. Recent breakthroughs in clustered, regularly interspaced, short palindromic repeat (CRISPR) technology...

Adverse outcome pathways (AOPs) are systems biology roadmaps with potential utility in xenobiotic exposure risk assessment. AOPs connect molecular initiating events (MIEs) to population-level adverse outcomes (AOs) via cellular, organ, and organism key events (KE) and KE relatio...

“Healthy Heart: Air Pollution and Cardiovascular Health” is a webinar presentation designed to introduce the fundamental epidemiological associations between ambient air pollution and cardiovascular health. Despite the phenomenal improvement in air quality across th...