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25
of 84 records from [ORD-NHEERL] from author Marina Evans
2020
Evans, M., C. Eklund, D. williams, Y. Sey, AND J. Simmons. Global Optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 32(3):97-109, (2020). https://doi.org/10.1080/08958378.2020.1742818
2019
Evans, M. Optimization of metabolic parameters using physiologically based pharmacokinetic (PBPK) modeling and chloroform (CHCl3) vapor-uptake inhalation data in F344 rats. Society ot Toxicology Annual Meeting, Baltimore, Maryland, March 10 - 14, 2019.
2018
Eklund, C., M. Evans, H. Yang, Y. Sey, AND J. Simmons. A Physiologically-Based Pharmacokinetic (PBPK) Model With Metabolic Interactions of Chloroform (CHCL3) and Trichloroethylene. Society of Toxicology, San Antonio, TX, March 11 - 15, 2018.
Evans, M. Computational prediction of dermal diffusivity for large number of chemicals – challenges and applications. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
Williams, D., M. Evans, J. Bruckner, AND J. Simmons. Local and global sensitivity analysis of a physiologically based pharmacokinetic model for oral uptake of carbon tetrachloride in rats. Tutorial Workshop on Parameter Estimation for Biological Models, Raleigh, NC, July 25 - 28, 2018.
Williams, D., J. Simmons, J. Bruckner, AND M. Evans. Prediction of internal dosimetry and toxicity of volatile chemicals in rats using physiologically based pharmacokinetic modeling: carbon tetrachloride as a model compound. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
2017
Sawyer, M., H. Tran, AND M. Evans. A physiologically based pharmacokinetic model of vitamin D. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 37(12):1448-1454, (2017).
Evans, M., P. Bozard, M. Hollister, A. Kinney, K. Lewis, AND A. Nikas. Predicting dermal penetration for Expocast chemicals using in silico approaches – should dermal metabolism be considered? Society of Toxicology, Baltimore, Maryland, March 12 - 16, 2017.
2016
Sawyer, M., Marina V. Evans, C. Wilson, L. Beesley, L. Leon, C. Eklund, E. Croom, AND R. Pegram. Development of a Human Physiologically Based Pharmacokinetics (PBPK) Model For Dermal Permeability for Lindane. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, 14(245):pp106-109, (2016).
Evans, M., M. Sawyer, K. Isaacs, AND J. Wambaugh. Predicting dermal penetration for ToxCast chemicals using in silico estimates for diffusion in combination with physiologically based pharmacokinetic (PBPK) modeling. Society of Toxicology, New Orleans, LA, March 13 - 17, 2016.
2015
Croom, E., Tim Shafer, M. Evans, W. Mundy, C. Eklund, A. Johnstone, C. Mack, AND R. Pegram. Improving In Vitro to In Vivo Extrapolation by Incorporating Toxicokinetic Measurements: A Case Study of Lindane-Induced Neurotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 283(1):9-19, (2015).
2013
CALDWELL, J. C., M. V. EVANS, AND K. Krishnan. Cutting Edge PBPK Models And Analyses: Providing The Basis For Future Modeling Efforts And Bridges To Emerging Toxicology Paradigms [Journal Article]. Journal of Toxicology. Hindawi Publishing Corporation, New York, NY, 2012:10, (2012).
2012
EVANS, M. V., W. Cuello, J. Jesse, M. Venecek, M. Sawyer, AND C. Eklund. Physiologically-based pharmacokinetic (PBPK) modeling to explore potential metabolic pathways of bromochloromethane in rats. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 2012(2012):629781, (2012).
EVANS, M. V., W. Cuello, J. Jessee, M. Venecek, M. Sawyer, AND C. R. EKLUND. Physiologically-based pharmacokinetic (PBPK) modeling to explore potential metabolic pathways of bromochloromethane in rats. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.
2011
Eklund, C. R., M. V. EVANS, AND J. E. SIMMONS. Evaluation of the Potential Impact of Inhibition of Trichloroethylene Metabolism in the Liver on Extra-Hepatic Toxicity. Presented at Society of Toxicology (SOT) Annual Meeting, Washington, DC, March 06 - 10, 2011.
Cuello, W., J. Simpson, M. Sawyer, M. V. EVANS, M. Sawyer, AND C. R. EKLUND. Physiologically-based pharmacokinetic (PBPK) modeling of metabolic pathways of bromochloromethane. Presented at Research Experience for Undergraduates (REU) Meeting, NC STATE UNIVERSITY, Raleigh, NC, May 31 - August 04, 2011.
EVANS, M. V., H. M. Yang, K. A. Yokley, A. MdDonald, Y. Sey, C. R. Eklund, AND J. E. SIMMONS. Physiologically-based pharmacokinetic (PBPK) modeling of two binary mixtures: metabolic activation of carbon tetrachloride by trichloroethylene and metabolic inhibition of chloroform by trichloroethylene. Presented at Society of Toxicology (SOT) Annual meeting, Washington, DC, March 06 - 10, 2011.
2010
Epps, P., J. Garcia, E. Lee, A. Walls, D. Frank, D. Eklund, AND M. V. EVANS. An alternate metabolic hypothesis for a binary mixture of trichloroethylene and carbon tetrachloride: application of physiologically based pharmacokinetic (PBPK) modeling in rats. Presented at Research Experience for Undergraduates Program- NC State Univ, Raleigh, NC, August 02 - 06, 2010.
EKLUND, C. R., M. V. EVANS, AND J. E. SIMMONS. Application of physiologically based pharmacokinetic (PBPK) model of trichloroethylene in rats for estimation of internal dose. Presented at Society of Toxicology 49th Annual meeting, Salt Lake City, UT, March 07 - 11, 2010.
EVANS, M. V., C. M. Eklund, U. Y. Sanzgiri, J. V. Bruckner, AND J. E. SIMMONS. Application of tissue time course data to elucidate mechanistic details of carbon tetrachloride (CC14) transport using an updated physiologically based pharmacokinetic (PBPK) model in rats. Presented at Society of Toxicology 49th Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.
EVANS, M. V. AND J. C. CALDWELL. Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic (PBPK) modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice *. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 244(3):280-290, (2010).
EVANS, M. V. AND J. C. CALDWELL. Letter to the editor of TAAP, in response to letter from Anders et al. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 248(1):65-67, (2010).
EVANS, M. V. The importance of data evaluation for PBPK model development and risk assessment application. Presented at Society for Risk Assessment Annual meeting, Salt Lake City, UT, December 05 - 08, 2010.
2009
EL-MASRI, H. A., S. DOWD, R. Pegram, R. A. HARRISON, S. YAVANHXAY, J. E. SIMMONS, AND M. V. EVANS. Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 21(14):1176-1185, (2009).
Draper, B., D. Marcin, A. Margolskee, R. Murden, A. Attarian, M. V. EVANS, AND K. YOKLEY. Feasibility of Metabolic Parameter Estimation in Pharmacokinetic Models of Carbon Tetrachloride Exposure in Rats. TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY. Taylor & Francis, Inc., Philadelphia, PA, 91(3):521-546, (2009).