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See all EPA publications for Sigmund Degitz Include records from any date Include records from any EPA source

Records 1 to 25 of 28 records from [ORD-NHEERL] published between 01/21/2013 and 01/21/2018 from author Sigmund Degitz

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2017

Haselman, J., S. Degitz, M. Hornung, Dan Villeneuve, J. Olker, S. Mayasich, D. Knapen, L. Vergauwen, AND E. Stinckens. A catalog of putative adverse outcome pathways (AOPs) that will enhance the utility of ToxCast high throughput screening data for hazard identification, delivered via a putative AOP knowledgebase and a ToxCast assay annotation file that can be linked with the iCSS dashboard. U.S. EPA Office of Research and Development, Washington, DC, 2017.

Olker, J., K. Donnay, J. Haselman, Pat Kosian, Joe Korte, M. Hornung, AND S. Degitz. A tiered approach to evaluate an iodine recycling inhibition adverse outcome pathway (AOP) in amphibians. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Kosian, Pat, Joe Korte, K. Donnay, R. Ford, J. Haselman, M. Hornung, J. Ford, M. Gilbert, AND S. Degitz. Analysis of thyroid hormones in biological samples using stable isotope dilution liquid chromatography-tandem mass spectrometry. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

Haselman, J., J. Nichols, M. Hornung, Pat Kosian, J. Olker, Joe Korte, AND S. Degitz. Computational modeling of the amphibian thyroid axis supported by targeted in vivo testing to advance quantitative adverse outcome pathway development. National Society of Toxicology Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Olker, J., J. Haselman, Pat Kosian, Joe Korte, M. Hornung, AND S. Degitz. Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

Hornung, M., Joe Korte, J. Olker, J. Denny, C. Knutsen, P. Hartig, M. Cardon, AND S. Degitz. In vitro screening for potential chemical inhibitors of deiodinase type 1 activity. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Hassan, I., H. El-Masri, Pat Kosian, J. Ford, S. Degitz, AND M. Gilbert. Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 160(1):57-73, (2017).

Hassan, I., H. El-Masri, Pat Kosian, J. Ford, R. Ford, M. Jasper, S. Degitz, AND M. Gilbert. Quantitative Adverse Outcome Pathway for Neurodevelopmental Effects of Thyroid Peroxidase-Induced Thyroid Hormone Synthesis Inhibition. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Denny, J., Joe Korte, C. Knutsen, J. Olker, S. Degitz, M. Hornung, P. Hartig, AND M. Cardon. Screening the ToxCast Phase I Chemical Library for inhibition of Deiodinase Type I enzyme activity. SETAC Midwest Chapter, Minneapolis, MN, July 20 - 22, 2017.

Denny, J., Joe Korte, C. Knutsen, J. Olker, J. Christensen, P. Kent, P. Hartig, M. Cardon, S. Degitz, AND M. Hornung. Screening the ToxCast Phase I, II, and e1K Chemical Libraries for Inhibition of Deiodinase Type 1,2 and 3 Enzyme Activity. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

Gilbert, M., S. Spring, J. Ford, R. Ford, C. Wood, S. Thomas, K. OShaughnessy, M. Hotchkiss, Pat Kosian, AND S. Degitz. Thyroid Hormone Insufficiency in the Pregnant Rat Induces Cortical Heterotopia in Offspring: PTU vs Perchlorate. Developmental Neurotoxicology Society (DNTS), Denver, Colorado, June 24 - 29, 2017.

Mayasich, S., P. Kent, C. Knutsen, S. Degitz, AND M. Hornung. Xenopus laevis deiodinase 3 expression for in vitro screening of potential chemical inhibitors. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

2016

Gilbert, M., K. Crofton, K. Paul-Friedman, J. Haselman, S. Degitz, M. Hornung, D. Knapen, L. Vergauwen, E. Stinckens, S. Marty, R. Zoeller, AND B. Demeniex. A Network of AOPs for reduced thyroid hormone synthesis derived from inhibition of Thyroperoxidase - A common Molecular Initiating Event Leading to Species-Specific Indices of Adversity. U.S. EPA Office of Research and Development, Washington, DC, 2016.

Haselman, J., M. Sakurai, N. Watanabe, Y. Goto, Y. Onishi, Y. Ito, Y. Onoda, Pat Kosian, Joe Korte, R. Johnson, T. Iguchi, AND S. Degitz. Development of the larval amphibian growth and development assay: Effects of benzophenone-2 exposure in Xenopus laevis from embryo to juvenile. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(12):1651-1661, (2016).

Haselman, J., Pat Kosian, Joe Korte, A. Olmstead, T. Iguchi, R. Johnson, AND S. Degitz. Development of the larval amphibian growth and development assay: Effects of chronic 4-tert-octylphenol or 17ß-trenbolone exposure in Xenopus laevis from embryo to juvenile. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(12):1639-1650, (2016).

Nelson, K., A. Schroeder, G. Ankley, B. Blackwell, C. Blanksma, S. Degitz, K. Jensen, R. Johnson, M. Kahl, D. Knapen, Pat Kosian, R. Milsk, E. Randolph, T. Saari, E. Stinckens, L. Vergauwen, AND Dan Villeneuve. Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-Mercaptobenzothiazole Part I: Fathead minnow. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 173:192-203, (2016).

Wang, Y., Pat Kosian, T. Nguyen, C. Anderson, J. Rumbley, S. Degitz, AND G. Anderson. Maternal iron deficiency alters circulating thyroid hormone levels in developing neonatal rats. American Thyroid Association (ATA), Denver, CO, September 21 - 25, 2016.

2015

Haselman, J., A. Olmstead, AND S. Degitz. Global gene expression during early differentiation of Xenopus (Silurana) tropicalis gonad tissues. GENERAL AND COMPARATIVE ENDOCRINOLOGY. Academic Press Incorporated, Orlando, FL, 214:103-113, (2015).

Hornung, M., Pat Kosian, J. Haselman, Joe Korte, K. Challis, C. Macherla, E. Nevalainen, AND S. Degitz. In vitro, ex vivo, and in vivo determination of thyroid hormone modulating activity of benzothiazoles. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 146(2):254-264, (2015).

Gilbert, M., W. Oshiro, S. Spring, M. Hotchkiss, Pat Kosian, AND S. Degitz. Structural Abnormalities and Learning Impairments Induced by Low Level Thyroid Hormone Insufficiency: A Cross-Fostering Study. Presented at Intl. Neurotoxicology Association Meeting, Montreal, Qu, CANADA, June 27 - July 01, 2015.

Haselman, J., Pat Kosian, Joe Korte, A. Olmstead, R. Johnson, AND S. Degitz. Xenopus laevis Müllerian ducts are sensitive indicators of estrogenic or androgenic chemical exposure in vivo. Society of Toxicology, San Diego, CA, March 22 - 26, 2015.

Haselman, J., Pat Kosian, Joe Korte, A. Olmstead, R. Johnson, AND S. Degitz. Xenopus laevis Müllerian ducts are sensitive indicators of estrogenic or androgenic chemical exposure in vivo (poster presentation). MWSETAC/SOT Meeting, Duluth, MN, March 09 - 11, 2015.

2014

Lynn, S., M. Hornung, M. Gilbert, S. Degitz, AND K. Crofton. A Risk-based Prioritization Strategy for Thyroid Disruption Under EDSP21. Presented at Teratology Society Meeting, Bellevue, WA, June 28 - July 02, 2014.

Nichols, J., M. Hornung, Joe Korte, J. Haselman, Joe Tietge, AND S. Degitz. A quantitative adverse outcome pathway model for thyroid axis disruption in Xenopus laevis tadpoles. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.

Hornung, M., J. Haselman, Joe Korte, Pat Kosian, K. Challis, S. Hall, AND S. Degitz. Comparison of in vitro and ex vivo thyroid hormone synthesis inhibition results and in vivo outcomes for a series of benzothiazoles. Presented at Society of Toxicology, Phoenix, AZ, March 24 - 27, 2014.