Office of Research and Development Publications

Records 1 to 55 of 55

2017
Phillips, K., J. Wambaugh, Chris Grulke, K. Dionisio, AND K. Isaacs. High-throughput screening of chemicals as functional substitutes using structure-based classification models. GREEN CHEMISTRY. Royal Society of Chemistry, Cambridge, Uk, 19:1063-1074, (2017).
2016
Brandon, N., K. Dionisio, K. Isaacs, D. Kapraun, Woodrow Setzer, AND R. Tornero-Velez. A Novel Framework for Characterizing Exposure-Related Behaviors Using Agent-Based Models Embedded with Needs-Based Artificial Intelligence (CSSSA2016). The Computational Social Science Society of the Americas, Santa Fe, NM, November 17 - 20, 2016.
Dionisio, K., Chris Nolte, T. Spero, S. Graham, N. Caraway, K. Foley, AND K. Isaacs. A changing climate: impacts on human exposures to O3 using an integrated modeling methodology. 2016 Annual International Society of Exposure Science Meeting, Utrecht, N/A, NETHERLANDS, October 09 - 13, 2016.
Price, P., N. Brandon, K. Dionisio, R. Tornero-Velez, AND K. Isaacs. A framework for the use of agent based modeling to simulate inter- and intraindividual variation in human behaviors. 2016 Annual International Society of Exposure Science Meeting, Utrecht, NETHERLANDS, October 09 - 13, 2016.
Dionisio, K., D. Vallero, P. Egeghy, K. Isaacs, K. Thomas, AND P. Price. A modular Human Exposure Model (HEM) framework to characterize near-field chemical exposure in LCIA and CAA. 2016 Annual International Society of Exposure Science Meeting, Utrecht, NETHERLANDS, October 09 - 13, 2016.
Isaacs, K. AND J. Wambaugh. Advances in EPA’s Rapid Exposure and Dosimetry Project (Interagency Alternatives Assessment Webinar). Interagency Alternatives Assessment Webinar, NA, NC, February 25, 2016.
Isaacs, K., K. Phillips, J. Wambaugh, AND P. Price. Analysis of Ingredient Lists to Quantitatively Characterize Chemicals in Consumer Products. SOT Annual Meeting 2016, New Orleans, LA, March 13 - 17, 2016.
Price, P., K. Isaacs, J. Wambaugh, A. Williams, K. Dionisio, AND K. Phillips. Characterizing the composition of commercial products for use in exposure assessments. Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13 - 17, 2016.
Egeghy, P., L. Sheldon, K. Isaacs, H. Ozkaynak, M. Goldsmith, J. Wambaugh, R. Judson, AND T. Buckley. Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(6):697–702, (2016).
Csiszar, S., D. Meyer, K. L. Dionisio, P. Egeghy, K. K. Isaacs, P. Price, K. Scanlon, Yu-Mei Tan, K. Thomas, D. Vallero, AND J. Bare. Conceptual Framework To Extend Life Cycle Assessment Using Near-Field Human Exposure Modeling and High-Throughput Tools for Chemicals. CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY. CRC Press LLC, Boca Raton, FL, 50(21):11922-11934, (2016).
Isaacs, K., K. Phillips, K. Dionisio, D. Biryol, AND P. Price. Development of a Harmonized Database of Reported and Predicted Consumer Product Ingredient Information. 2016 Annual International Society of Exposure Science Meeting, Utrecht, NETHERLANDS, October 09 - 13, 2016.
Wetmore, B., J. Wambaugh, K. Isaacs, R. Tornero-Velez, R. Thomas, J. Simmons, Woodrow Setzer, R. Sayre, R. Pearce, D. Kapraun, B. Ingle, M. Hughes, Chris Grulke, M. Ecklund, M. Evans, AND Lindad Adams. Evaluating and Refining High Throughput Tools for Toxicokinetics. CSS BoSC Meeting, RTP, NC, November 16 - 18, 2016.
Leonard, J., A. Sobel Leonard, D. Chang, S. Edwards, J. Lu, S. Scholle, P. Key, M. Winter, K. Isaacs, AND C. Tan. Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50(11):5961–5971, (2016).
Isaacs, K. High-Throughput Predictive Approaches to Evaluating Chemicals in Food Contact Materials: Migration, Exposure, and Alternatives Identification. Identifying and Evaluating Alternative Materials: The Case of BPA-Free Can Linings, Berkeley, CA, November 04, 2016.
Isaacs, K., K. Phillips, P. Egeghy, K. Dionisio, AND J. Wambaugh. Leveraging Publically Available Chemical Functional Use Data in Support of Exposure Prediction. 2016 Annual International Society of Exposure Science Meeting, Utrecht, NETHERLANDS, October 09 - 13, 2016.
Rager, J., M. Strynar, S. Liang, R. McMahen, A. Richard, C. Grukle, J. Wambaugh, K. Isaacs, R. Judson, A. Williams, AND J. Sobus. Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 88:269-280, (2016).
Isaacs, K., C. Nicolas, D. Biryol, AND J. Wambaugh. Predicting SVOC Emissions into Air and Foods in Support of High-Throughput Exposure Assessment. 2016 Annual ISES Meeting, Utrecht, NETHERLANDS, November 09 - 13, 2016.
Phillips, K., J. Wambaugh, P. Egeghy, C. Grulke, AND K. Isaacs. Quantitative structure-property relationships for chemical functional use and weight fractions in consumer articles. Society of Toxicology Annual Meeting, New Orleans, LA, March 13 - 17, 2016.
Dionisio, K. AND K. Isaacs. The High-Throughput Stochastic Human Exposure and Dose Simulation Model (SHEDS-HT) & The Chemical and Products Database (CPDat). 2016 Annual ISES Meeting, Utrecht, NETHERLANDS, October 09 - 13, 2016.
2015
Tornero-Velez, R., K. Isaacs, K. Dionisio, AND P. Price. An Agent-Based Model Representation of a Probabilistic Human Chemical Exposure Model. SwarmFest 2015: 19th Annual Meeting on Agent-Based Modeling & Simulation, Columbia, SC, July 10 - 12, 2015.
Dionisio, K., Chris Nolte, T. Spero, AND K. Isaacs. Characterizing climate change impacts on human exposures to air pollutants. ISES Annual Meeting, Henderson, NV, Henderson, NV, October 18 - 23, 2015.
Tornero-Velez, R., K. Isaacs, M. Nye, AND T. Buckley. Evaluation of Consumer Product Co-occurrence to Inform Chemical Exposure. ISES Annual Meeting, Henderson, NV, Henderson, NV, October 18 - 23, 2015.
Isaacs, K., R. Tornero-Velez, M. Nye, AND T. Buckley. Exposure-Relevant Consumer Product Usage Information Derived from Longitudinal Purchasing Data. ISES Annual Meeting, Henderson, NV, Henderson, NV, October 18 - 23, 2015.
Isaacs, K. High Throughput Methods for Estimating Human Exposures to Chemicals in EPA's ExpoCast Program. ILSI Technical Committee on Food & Chemical Safety, Washington, DC, May 13, 2015.
Biryol, D., K. Phillips, C. Nicolas, J. Wambaugh, AND K. Isaacs. High-Throughput Dietary Exposure Predictions for Chemical Migrants from Food Packaging Materials. ISES Annual Meeting, Henderson, NV, Henderson, NV, October 18 - 23, 2015.
Isaacs, K. Predicting Human Exposures to Chemicals Across Chemical and Use Domains for Risk-Based Prioritization. ICCA-LRI - EPA Workshop, New Orleans, LA, June 15, 2015.
Setzer, Woodrow, J. Wambaugh, AND K. Isaacs. Progress in High Throughput Exposure Assessment for Prioritizing Human Exposure to Environmental Chemicals (SRA). Presented at Society for Risk Assessment, Arlington, VA, December 06 - 10, 2015.
Goldsmith, M., D. Chang, A. Deschenes, K. Phillips, K. Isaacs, AND J. Wambaugh. Quantitative structure-Functional Ingredient Relationships (qFIRs): Development of a data-driven workflow for alternatives ingredient assessments for in silico molecular repurposing. American Chemical Society National Meeting, Boston, MA, August 16 - 20, 2015.
Isaacs, K. AND P. Egeghy. The Need for a Harmonized Repository for Next-Generation Human Activity Data. ISES Annual Meeting, Henderson, NVISES 2015 Annual Meeting, Henderson, NV, October 18 - 23, 2015.
Tornero-Velez, R., K. Isaacs, AND P. Price. Using Agent-Based Approaches to Characterize Exposure Related Behavior. ISES 2015 Annual Meeting, Henderson, NV, October 18 - 22, 2015.
Price, P., K. Phillips, AND K. Isaacs. Using Ingredient Lists to Quantitatively Characterize Composition of Consumer Products. ISES 2015 Annual Meeting, Henderson, NV, October 18 - 22, 2015.
2014
Goldsmith, M., P. Egeghy, AND K. Isaacs. . Cheminformatic exploration of the chemical landscape of consumer products. Presented at ISES 2014, Cincinnati, OH, October 12 - 16, 2014.
Phillips, M., J. Sobus, Barbara J. George, K. Isaacs, R. Conolly, AND C. Tan. A New Method for Generating Distribution of Biomonitoring Equivalents to Support Exposure Assessment and Prioritization. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 69(3):434-442, (2014).
Goldsmith, M. AND K. Isaacs. Developing a Passive Time-Activity Triage System In support of Consumer Ingredient Exposure Prioritization. Presented at ISES 2014, Cincinnati, OH, October 12 - 16, 2014.
Goldsmith, M. AND K. Isaacs. Developing a Passive Time-Activity Triage System In support of Consumer Ingredient Exposure Prioritization. 24th Annual ISES Conference 2014, Cincinnati, OH, October 12 - 16, 2014.
Goldsmith, Rocky, Chris Grulke, R. Brooks, T. Transue, C. Tan, A. Frame, P. Egeghy, R. Edwards, D. Chang, R. Tornero-Velez, K. Isaacs, A. Wang, J. Johnson, K. Holm, M. Reich, J. Mitchell, D. Vallero, L. Phillips, M. Phillips, J. Wambaugh, R. Judson, T. Buckley, AND C. Dary. Development of a Consumer Product Ingredient Database for Chemical ExposureScreening and Prioritization. FOOD AND CHEMICAL TOXICOLOGY. Elsevier Science Ltd, New York, NY, 65:269-279, (2014).
Breen, M., T. Long, Brad Schultz, J. Crooks, M. Breen, J. Langstaff, K. Isaacs, C. Tan, R. Williams, Y. Cao, A. Geller, R. Devlin, S. Batterman, AND T. Buckley. GPS-based Microenvironment Tracker (MicroTrac) Model to Estimate Time-Location of Individuals for Air Pollution Exposure Assessments: Model Evaluation in Central North Carolina. ATMOSPHERIC ENVIRONMENT. Elsevier Science Ltd, New York, NY, 24(4):412-420, (2014).
Tulve, N., K. Isaacs, R. Williams, T. McCurdy, L. Phillips, C. Croghan, AND H. Ozkaynak. How Questionnaires and Multimedia Measurements collected in the U.S. EPA’s Observational Human Exposure Measurement Studies Inform Exposures. ISES 2014 Annual Meeting, Cincinnati, OH, October 12 - 16, 2014.
Isaacs, K., W. Glen, P. Egeghy, D. Vallero, M. Goldsmith, AND H. Ozkaynak. Other Perspectives for Developing Exposure Estimates: “SHEDS-Lite: Rapid Scenario-Based ExposurePredictions for Chemicals with Near-Field and Dietary Pathways”. 24th Annual ISES Meeting, Cincinnati, OH, October 12 - 16, 2014.
Breen, M., Brad Schultz, M. Sohn, T. Long, J. Langstaff, R. Williams, K. Isaacs, Q. Meng, C. Stallings, AND L. Smith. Review of Air Exchange Rate Models for Air Pollution Exposure Assessments. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 24(6):555-563, (2014).
Isaacs, K., G. Glen, P. Egeghy, R. Goldsmith, L. Smith, D. Vallero, R. Brooks, Chris Grulke, AND H. Ozkaynak. SHEDS-HT: An Integrated Probabilistic Exposure Model for Prioritizing Exposures to Chemicals with Near-Field and Dietary Sources. ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 48(21):12750-12759, (2014).
2013
Stout, Dan, A. Mysz, E. Snyder, L. Oudejans, P. Lemieux, T. Boe, J. Starr, K. Isaacs, H. Ozkaynak, D. Tabor, AND J. Martinez. Developing Decontamination Tools and Approaches to Address Indoor Pesticide Contamination from Improper Bed Bug Treatments. Presented at 2013 EPA International Decontamination Research and Development Conference, RTP, NC, November 05 - 07, 2013.
Ozkaynak, H., K. Isaacs, J. Xue, Rocky Goldsmith, P. Egeghy, D. Vallero, AND J. Wambaugh. High Throughput Exposure Prioritization of Chemicals Using a Screening-Level Probabilistic SHEDS-Lite Exposure Model. Presented at Annual Joint Conference ISEE/ISES/ISIAQ, basel, SWITZERLAND, August 19 - 23, 2013.
Isaacs, K., J. Burke, L. Smith, AND R. Williams. Identifying Housing and Meteorological Conditions Influencing Residential Air Exchange Rates in the DEARS and RIOPA Studies: Development of Distributions for Human Exposure Modeling. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 23(3):248-258, (2013).
Vallero, D., P. Egeghy, T. Buckley, J. Wambaugh, K. Isaacs, Rocky Goldsmith, H. Ozkaynak, AND J. Mitchell. Mapping ExpoCast onto ToxCast. Presented at ISES, Basel, SWITZERLAND, August 19 - 23, 2013.
Isaacs, K., Chris Grulke, R. Brooks, M. Reich, R. Edwards, AND Rocky Goldsmith. Mining Internet search and social media for epidemiology. Chapter 222, McGraw-Hill Handbook of Science & Technology. McGraw-Hill Companies, New York, NY, , 222-227, (2014).
ISAACS, K. K., T. R. MCCURDY, G. Glen, M. Nyswander, A. ERRICKSON, S. Forbes, S. E. GRAHAM, L. McCurdy, L. Smith, N. S. TULVE, AND D. A. VALLERO. Statistical Properties of Longitudinal Time-Activity Data for Use in Human Exposure Modeling. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 23(3):328-336, (2013).
2012
Glen, G. AND K. K. ISAACS. Estimating Sobol Sensitivity Indices Using Correlations. ENVIRONMENTAL MODELLING AND SOFTWARE. Elsevier Science Ltd, New York, NY, 37(November, 2012):157-166, (2012).
ISAACS, K. K., J. A. ROSATI, AND T. B. MARTONEN. Modeling Deposition of Inhaled Particles . Second EditionChapter 5, Lev S. Ruzer, Naomi H. Harley (ed.), Handbook: Measurement, Dosimetry, and Health Effects. CRC Press - Taylor & Francis Group, LLC, Boca Raton, FL, , 83-127, (2012).
2008
GLEN, G., L. SMITH, K. K. ISAACS, T. R. MCCURDY, AND J. LANGSTAFF. A NEW METHOD OF LONGITUDINAL DIARY ASSEMBLY FOR HUMAN EXPOSURE MODELING. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 18(3):299-311, (2008).
ISAACS, K. K., G. GLEN, T. R. MCCURDY, AND L. SMITH. MODELING ENERGY EXPENDITURE AND OXYGEN CONSUMPTION IN HUMAN EXPOSURE MODELS: ACCOUNTING FOR FATIGUE AND EPOC. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 18(3):289-298, (2007).
2005
GLEN, G., L. SMITH, K. ISAACS, T. R. MCCURDY, AND J. LANGSTAFF. A NEW METHOD OF LONGITUDINAL DIARY ASSEMBLY FOR EXPOSURE MODELING. Presented at International Society of Exposure Analysis Conference, Tucson, AZ, October 30 - November 03, 2005.
ISAACS, K., G. GLEN, T. R. MCCURDY, AND L. SMITH. CORRECTING ENERGY EXPENDITURES FOR FATIGUE AND EXCESS POST-EXERCISE OXYGEN CONSUMPTION. Presented at International Society of Exposure Analysis Conference, Tucson, AZ, October 30 - November 03, 2005.
SMITH, L., L. LIAO, K. ISAACS, T. R. MCCURDY, AND J. XUE. PHYSICAL ACTIVITY INDEX FOR CHILDREN: A COMPARISON OF LITERATURE VALUES AND EPA'S CHAD. Presented at International Society of Exposure Analysis Conference, Tucson, AZ, October 30 - November 03, 2005.
2002
Isaacs, K K., M V. Evans, AND T. R. Harris. VISUALIZATION-BASED ANALYSIS FOR A MIXED-INHIBITION BINARY PBPK MODEL: DETERMINATION OF INHIBITION MECHANISM. Presented at Fifth Tennessee Conference on Biomedical Engineering, Memphis, TN, April 4-6, 2002.