Office of Research and Development Publications

Records 1 to 25 of 862

Alternative Approaches to Chemical Risk Assessment: Assays, Databases, Models (Mich. State U lecture) (PRESENTATION)
presentation at Michigan State University Dept. of Pharmacology and Toxicology Alternative Approaches to Chemical Risk Assessment: Assays, Databases, Models
CHEMICAL PRIORITIZATION FOR DEVELOPMENTAL TOXICITY USING LITERATURE MINING-BASED WEIGHTING OF TOXCAST ASSAYS (PRESENTATION)
Defining a predictive model of developmental toxicity from in vitro and high-throughput screening (HTS) assays can be limited by the availability of developmental defects data. ToxRefDB (www.epa.gov/ncct/todrefdb) was built from animal studies on data-rich environmental chemicals...
Identifying "known unknowns": A comparison between ChemSpider and the US EPA's CompTox Dashboard (ACS Spring National meeting) 1 of 7 (PRESENTATION)
Non-targeted analysis (NTA) workflows in high-resolution mass spectrometry require mechanisms for compound identification. One strategy for tentative identification is the use of online chemical databases such as ChemSpider. Databases like this use molecular formulae and monois...
In vitro data and in silico models for computational toxicology (Teratology Society ILSI HESI workshop) (PRESENTATION)
The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...
Incorporating new technologies and high-throughput approaches in the design and selection of chemical alternatives (21st Annual Green Chemistry & Engineering Conference) (PRESENTATION)
Presentation at the 21st Annual Green Chemistry & Engineering Conference on Incorporating new technologies and high-throughput approaches in the design and selection of chemical alternatives
Large Dataset of Acute Oral Toxicity Data Created for Testing in Silico Models (ASCCT meeting) (PRESENTATION)
Acute toxicity data is a common requirement for substance registration in the US. Currently only data derived from animal tests are accepted by regulatory agencies, and the standard in vivo tests use lethality as the endpoint. Non-animal alternatives such as in silico models are ...
(BOSC) DOSE-RESPONSE MODELING FOR THE ASSESSMENT OF CUMULATIVE RISK DUE TO EXPOSURE TO N-METHYL CARBAMATE PRESTICIDES (PRESENTATION)
THE US EPA'S N-METHYL CARBAMATE CUMULATIVE RISK ASSESSMENT (NMCRA) ASSESSES THE EFFECT ON ACETYLCHOLINE ESTERASE (AChE) ACTIVITY OF EXPOSURE TO 10 N-METHLY CARBAMATE (NMC)PESTICIDES THROUGH DIETARY, DRINKING WATER, AND RESIDENTIAL EXPOSURES. THESE DATA THUS INFORM, BUT DO NOT COM...
(ISEA) IDENTIFYING IMPORTANT FACTORS INFLUENCING CHILDREN'S EXPOSURES TO PESTICIDES (PRESENTATION)
Template for symposia abstracts submission; requirements for symposium organisers.(European Spelling)
(WISCONSIN) OVERVIEW OF US EPA RESEARCH ACTIVITIES AIMED AT CHARACTERIZING CHILDRENS EXPOSURES (PRESENTATION)
Overview of significant research activities that have been initiated by the USEPA to increase understanding of children’s vulnerabilities and to better characterize children’s exposures to chemical stressors.
*Comparative pharmacokinetics of perfluorononanoic acid in rats and mice (PRESENTATION)
Perfluorononanoic acid (PFNA), a member of the perfluoroalkyl acids (PFAAs) is found at low concentrations in the environment, but detectable in humans and wildlife. Previous studies have examined the pharmacokinetics (PK) of shorter carbon-chain PFAAs, such as perfluorobutyric a...
2008 HESI Emerging Issue: Identification of Pharmaceuticals for Validation of ToxCast (PRESENTATION)
Slide presentation to discuss identification of pharmaceuticals for validation of ToxCast.
2009 International Workshop on Virtual Tissues (PRESENTATION)
Internal presentation on how virtual tissues will improve understanding of molecular and cellular pathways to efficiently analyze thousands of environmental contaminants.
20161009 - New Data from EPA's Exposure Forecasting (ExpoCast) Project (ISES meeting) (PRESENTATION)
The health risks posed by the chemicals in our environment depends on both chemical hazard and exposure. However, relatively few chemicals have estimates of exposure intake, limiting risk estimations for thousands of chemicals. The U.S. EPA Exposure Forecasting (ExpoCast) projec...
20161106 - Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals (ACT meeting) (PRESENTATION)
Worldwide initiatives to screen for toxicity potential among the thousands of chemicals currently in use require inexpensive and high-throughput in vitro models to meet their goals. The devTOX quickPredict platform is an in vitro human pluripotent stem cell-based assay used to as...
20170823 - Breaking Out of Groundhog Day: A Path Forward for New Approach Methods in Toxicology (WC10) (PRESENTATION)
Presentation at the 10th World Congress on Alternatives and Animal Use in the Life Sciences on a Path Forward for New Approach Methods in Toxicology
20170824 - A New Tox21 Strategic Plan and the Integration of EPA Science (WC10) (PRESENTATION)
The predominant focus of Tox21 collaboration has been on developing and applying high-throughput in vitro screening to hazard identification and dose-response. To remain relevant, the interagency collaboration must broaden its focus to developing new predictive toxicology testing...
20170824 - Enhancing the Application of Alternative Methods Through Global Cooperation (WC10) (PRESENTATION)
Progress towards the development and translation of alternative testing methods to safety-related decision making is a common goal that crosses organizational, stakeholder, and international boundaries. The challenge is that different organizations have different missions, differ...
A BIOLOGIST'S PERSPECTIVE ON)ESTIMATING LOW-DOSE RISK FROM HIGH-DOSE DATA AND ITS ASSOCIATED UNCERTAINTY (PRESENTATION)
Risk at a given exposure is determined by biological processes.
A Balanced Accuracy Fitness Function Leads to Robust Analysis Using Grammatical Evolution Neural Networks in the Case of Class Imbalance (PRESENTATION)
The identification and characterization of genetic and environmental factors that predict common, complex disease is a major goal of human genetics. The ubiquitous nature of epistatic interaction in the underlying genetic etiology of such disease presents a difficult analytical ...
A Biologically Informed Framework for the Analysis of the PPAR Signaling Pathway using a Bayesian Network (PRESENTATION)
The US EPA’s ToxCastTM program seeks to combine advances in high-throughput screening technology with methodologies from statistics and computer science to develop high-throughput decision support tools for assessing chemical hazard and risk. To develop new methods of analysis of...
A Boolean Network Model of Nuclear Receptor Mediated Cell Cycle Progression (PRESENTATION)
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate a broad range of cellular processes. Hormones, lipids and xenobiotics have been shown to activate NRs with a range of consequences on development, metabolism, oxidative stress, apoptosis, and prolif...
A Boolean Network Model of Nuclear Receptor Mediated Cell Cycle Progression (S) (PRESENTATION)
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate a broad range of cellular processes. Hormones, lipids and xenobiotics have been shown to activate NRs with a range of consequences on development, metabolism, oxidative stress, apoptosis, and prolif...
A Call for Nominations of Quantitative High-Throughput Screening Assays from Relevant Human Toxicity Pathways (PRESENTATION)
The National Research Council of the United States National Academies of Science has recently released a document outlining a long-range vision and strategy for transforming toxicity testing from largely whole animal-based testing to one based on in vitro assays. “Toxicity Testin...
A Collaborative Web-Based Architecture For Sharing ToxCast Data (PRESENTATION)
Collaborative Drug Discovery (CDD) has created a scalable platform that combines traditional drug discovery informatics with Web2.0 features. Traditional drug discovery capabilities include substructure, similarity searching and export to excel or sdf formats. Web2.0 features inc...
A Computational Framework for Systems-based Analysis of Developmental Toxicity (PRESENTATION)
Discusses the EPA/NCCT ToxRefDB database. The EPA is building capacity for multi-dimensional evaluation of toxicity using information aboout chemical properties, genome-wide responses, and cell-based assays.