Office of Research and Development Publications

Records 1 to 25 of 228

McCollum, C., J. Conde Vancells, C. Hans, M. Vazquez-Chantada, N. Kleinstreuer, T. Tal, T. Knudsen, S. Shah, F. Merchant, R. Finnell, J. Gustafsson, R. Cabrera, AND M. Bondesson. Identification of vascular disruptor compounds by a tiered analysis in ebrafish embryos and mouse embryonic endothelial cells. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 70:60-69, (2017).
Zang, Q., K. Mansouri, A. Williams, R. Judson, D. Allen, W. Casey, AND N. Kleinstreuer. In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning. Journal of Chemical Information and Modeling. American Chemical Society, Washington, DC, 57(1):36-49, (2017).
Kleinstreuer, N., P. Ceger, Eric Watt, M. Martin, K. Houck, P. Browne, R. Thomas, W. Casey, D. Dix, D. Allen, S. Sakamuru, M. Xia, R. Huang, AND R. Judson. (Chemical Research in Toxicology) Development and Validation of a Computational Model for Androgen Receptor Activity. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 30(4):946-964, (2017).
Fitzpatrick, J. AND G. Patlewicz. Application of IATA - A case study in evaluating the global and local performance of a Bayesian Network model for Skin Sensitization. SAR AND QSAR IN ENVIRONMENTAL RESEARCH. Taylor & Francis, Inc., Philadelphia, PA, 28(4):297-310, (2017).
Sauer, S., M. Tarpley, I. Shah, A. Save, H. Lyerly, S. Patierno, K. Williams, AND G. Devi. Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptornegative inflammatory breast cancer cells. CARCINOGENESIS. Oxford University Press, Cary, NC, 38(3):252–260, (2017).
Hutson, S., M. Leung, N. Baker, R. Spencer, AND T. Knudsen. Computational Model of Secondary Palate Fusion and Disruption. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 30(4):965-979, (2017).
Escher, B., J. Hackermüller, T. Polte, S. Scholz, A. Aigner, R. Altenburger, A. Bohme, S. Bopp, W. Brack, W. Busch, M. Chadeau-Hyam, A. Covaci, A. Eisentrager, J. Galligan, N. Garcia-Reyero, T. Hartung, M. Hein, G. Herberth, A. Jahnke, J. Kleinjans, N. Kluever, M. Krauss, M. Lamoree, I. Lehmann, T. Luckenbach, G. Miller, A. Mueller, D. Phillips, S. Rappaport, T. Reemtsma, U. Rolle-Kampczyk, G. Schuurmann, B. Schwikowski, C. Tan, S. Trump, S. Walter-Rohde, AND J. Wambaugh. From the exposome to mechanistic understanding of chemical-induced adverse effects. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 99:97-106, (2017).
Juberg, D., T. Knudsen, M. Sander, N. Beck, E. Faustman, D. Mendrick, J. Fowle, T. Hartung, R. Tice, E. Lamazurier, R. Becker, S. Fitzpatrick, G. Daston, A. Harill, R. Hines, D. Keller, J. Lipscomb, D. Watson, T. Bahadori, AND K. Crofton. FutureTox III: Bridges for Translation. TOXICOLOGICAL SCIENCES. Society of Toxicology, 155(1):22-31, (2017).
Pearce, R., C. Strope, Woodrow Setzer, N. Sipes, AND J. Wambaugh. HTTK: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software. American Statistical Association, Alexandria, VA, 79(4):1-26, (2017).
Lynch, C., S. Sakamuru, R. Huang, D. Stavea, L. Varticovski, G. Hagar, Richard S. Judson, Keith A. Houck, N. Kleinstreuer, W. Casey, R. Paules, A. Simeonov, AND M. Xia. Identifying Environmental Chemicals as Agonists of the Androgen Receptor by Applying a Quantitative High-throughput Screening Platform. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 385:48-58, (2017).
Kapraun, Dustin F., John F. Wambaugh, R. Tornero-Velez, AND R. Woodrow Setzer. Identifying Prevalent Chemical Mixtures in the US Population. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 125(8):1-16, (2017).
McEachran, A., J. Sobus, AND A. Williams. Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard. Analytical and Bioanalytical Chemistry. Springer, New York, NY, 409(7):1729-1735, (2017).
Ring, C., R. Pearce, Woodrow Setzer, B. Wetmore, AND J. Wambaugh. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 106:105-118, (2017).
Fitzpatrick, J., D. Roberts, AND G. Patlewicz. Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for Skin Sensitization. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 37(1):117-127, (2017).
Patlewicz, G., G. Helman, P. Pradeep, AND I. Shah. Navigating through the minefield of read-across tools: A review of in silico tools for grouping. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 3:1-18, (2017).
Farmahin, R., A. Williams, B. Kuo, N. Chepelev, Russell S. Thomas, T. Burton-Maclaren, I. Curran, A. Nong, M. Wade, AND C. Yauk. Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment. Archives of Toxicology. Springer, New York, NY, 91(5):2045-2065, (2017).
Judson, Richard S., M. Martin, G. Patlewicz, AND Charles E. Wood. Retrospective Mining of Toxicology Data to Discover Multispecies and Chemical Class Effects: Anemia as a Case Study. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 86:74-92, (2017).
Fitzpatrick, J., D. Roberts, AND G. Patlewicz. What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 37(1):105-116, (2017).
Sluka, J., X. Fu, M. Swat, J. Belmonte, A. Cosmanescu, S. Clendenon, J. Wambaugh, AND J. Glazier. A Liver-centric Multiscale Modeling Framework for Xenobiotics. PLoS ONE . Public Library of Science, San Francisco, CA, , 1-40, (2016).
Shen, L., R. Judson, F. Melnikov, J. Roethle, A. Guidanda, J. Zimmerman, AND P. Anastas. A Probablistic Diagram to Guide Chemical Design with Reduced Potency to Incur Cytotoxicity. GREEN CHEMISTRY. Royal Society of Chemistry, Cambridge, Uk, 18:4461-4467, (2016).
Mansouri, K., Chris Grulke, A. Richard, R. Judson, AND A. Williams. An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modeling. SAR AND QSAR IN ENVIRONMENTAL RESEARCH. Taylor & Francis, Inc., Philadelphia, PA, 27(11):911-937, (2016).
Judson, R., K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh, Woodrow Setzer, P. Kothiya, J. Phuong, D. Filer, D. Smith, D. Reif, D. Rotroff, N. Kleinstreuer, N. Sipes, M. Xia, R. Huang, K. Crofton, AND R. Thomas. Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. TOXICOLOGICAL SCIENCES. Society of Toxicology, 152(2):323-339, (2016).
Kuo, B., F. Webster, R. Thomas, AND C. Yauk. BMDExpress Data Viewer: A Visualization Tool to Analyze BMDExpress Datasets. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(8):1048-1059, (2016).
Ball, N., M. Cronin, J. Shen, M. Adenuga, K. Blackburn, E. Booth, M. Bouhifd, B. Donley, L. Egnash, J. Freeman, C. Hastings, D. Juberg, A. Kleensang, N. Kleinstreuer, D. Kroese, T. Luechtefeld, A. Maertens, S. Marty, J. Naciff, J. Palmer, D. Pamies, M. Penman, A. Richarz, D. Russo, D. Steup, S. Stuard, G. Tier, B. van Ravenzwaay, S. Wu, H. Zhu, AND T. Hartung. CAAT Altex workshop paper entitled "Towards Good Read-Across Practice (GRAP) Guidance". ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 33(2):149-166, (2016).