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Background: Complex contributions of environment to health are intimately connected to human behavior. Modeling of human behaviors helps inform important policy decisions related to critical environmental and public health challenges. There are many approaches to human behavior m...

This is a short presentation to the Subcommittee on Chemical Exposures of the President's Task Force on Environmental Health Risks and Safety Risks to Children. The presentation briefly touches on the STAR program history of ORD funding for Children's Centers, and discusses our c...

Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...

These data were recently presented at SOT 2024 as a poster, and this sub-product will present the same data and analyses in a presentation at a local society meeting of endocrine disrupting chemicals NC (EDC-NC). Sprague-Dawley rat dams were exposed via oral gavage from GD18-22 t...

EPA&rsquo;s Report on the Environment (ROE) brings together the most reliable and readily available indicators to create a comprehensive view of the nation&rsquo;s environmental and human health status and trends. The indicators provide an objective basis for Agency decision maki...

Background and Purpose The identification of chemicals with the potential to disrupt androgen signaling is a key component of the EPA&rsquo;s Endocrine Disruption Screening Program (EDSP). EPA researchers have worked to devise in vitro assays and computational models to serve as ...

Background:&nbsp;While benefits of greenness to health have been reported, findings specific to child respiratory health are inconsistent. Methods:&nbsp;We utilized a prospective birth cohort followed from birth to age 7 years (n = 617). Residential surrounding greenness was quan...

Lead (Pb) and arsenic (As) contamination of soils is widespread in the United States and is an important source of exposure in young children. Early life exposure to metal(loid) contaminants has serious and long-lasting effects on health, making mitigation a critical public healt...

Background.&nbsp; When chemical health hazards have been identified, probabilistic dose&ndash;response assessment (&ldquo;hazard characterization&rdquo;) quantifies uncertainty and/or variability in toxicity as a function of human exposure. Existing probabilistic approaches diffe...

Humans interact with thousands of chemicals. This study aims to identify substances of emerging concern and in need of human health risk evaluations. Sixteen pooled human serum samples were constructed from 25 individual samples each from the National Institute of Environmental H...

This is a presentation abstract for proposed session, ID 141, Advances in New Approach Methods for Thyroid Toxicity Testing, for the SOT 2024 Annual Meeting.&nbsp; Abstract: There is significant regulatory need to evaluate chemicals that may disrupt the thyroid endocrine system. ...

Morphogenesis&nbsp;of the blood-brain barrier (BBB) is a complex process linked to&nbsp;neovascularization&nbsp;of the embryonic&nbsp;neural tube. This selective transport interface forms between vascular-neural compartments during&nbsp;organogenesis&nbsp;and dysregulation has be...

Background: Observational epidemiologic studies provide critical data for the evaluation of the potential effects of environmental, occupational and behavioural exposures on human health. Systematic reviews of these studies play a key role in informing policy and practice. System...

To make a dataset FAIR, it is imperative that data sets are internally consistent, nonredundant, unambiguous, and accessible. An example of making FAIR data is provided by the US EPA Integrated Risk Information System (IRIS) Program&rsquo;s inclusion of the Environmental Health V...

A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental adverse ef...

Per and polyfluoroalkyl substances (PFAS) are a large class of fluorinated organic chemicals of interest to regulatory agencies due to their prevalence and persistence in the environment. Multiple PFAS have been identified as endocrine disrupting chemicals due to estrogen recepto...

Socially isolated individuals and communities often face psychosocial stressors in combination with exposure to high levels of air pollutants. Social isolation (SI) has been considered a risk factor for neuropsychiatric conditions and is also linked to increased metabolic disorde...

Multiple per- and polyfluoroalkyl ether acids have recently been detected in drinking water and/or human serum, but there is a paucity of data on potential toxicity despite known exposure.&nbsp; Perfluoro-2-methoxyacetic acid (PFMOAA) is a short chain ether carboxylate (3 carbons...

Thyroid hormones (TH) are highly iodinated molecules that regulate many aspects of mammalian physiology and are essential for normal growth and development. Deiodinases (DIO) are a family of three metabolizing enzymes (DIO1, DIO2, DIO3) by activating or deactivating TH action. Th...

BACKGROUND. While major pathways of human PFAS exposure are thought to be drinking water and diet, other pathways and sources have also been shown to contribute to a person’s cumulative exposure. However, the degree of contribution of these other sources to PFAS body burdens is s...

Abstract reduced to fit RAPID character limits - full abstract attached Background and Purpose Recent human and ecological biomonitoring studies in the US and China have identified novel perfluoroalkyl carboxylic acids with ether linkages between each fluorinated carbon in a homo...

Background and Purpose: During the sensitive perinatal period, environmental stressors are a threat to brain development. We applied proteomics to investigate the protein changes occurring during the early postnatal rat cerebellum development. Methods: High-resolution mass spect...

Due to the pervasive detection of multiple PFAS in human and environmental matrices, many health-based agencies are employing or pursuing cumulative assessment and regulatory approaches.&nbsp; However, the literature is lacking mammalian in vivo studies that test additivity by co...

RATIONALE&nbsp; Air pollution exposure in pregnancy may affect fetal growth, and fetal growth restriction (FGR) is associ&shy;ated with lung im&shy;pairment that can persist into adulthood. Associated diseases include asthma, pulmonary hypertension (PH), and chronic obstructive p...

The period of neurodevelopment is vulnerable to various insults, including those produced by environmental compounds. We have previously observed behavioral alterations (uncoordinated hindlimb gait, decreased startle response, altered motor activity ontogeny) following perinatal ...