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In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the ...

Introduction (120/120): The US EPA is developing new approach methodologies (NAMS) to rapidly evaluate thousands of data-poor chemicals for human health hazards. These NAMs include&nbsp;in vitro exposures to investigate chemical metabolism in novel cell systems to inform hazard a...

Poly- and perfluoroalkyl substances (PFAS) are a large class of halogenated organic compounds (HOCs, also called organohalogens) utilized in a variety of industrial applications. Despite their widespread use in bulk quantities, significant concerns have been raised regarding thei...

During the past century, a vast number of organic chemicals have been manufactured and used in industrial, agricultural, public health, consumer products, and other applications. The widespread use in bulk quantities of halogenated organic chemicals (HOCs; also called as Organoha...

Halogenated organic compounds (HOCs) are long-lived toxic compounds and are of major concern for ecosystem and health. The use and manufacture of several HOCs is banned or phased out in most countries, but some HOCs are still being used in several countries. The levels of certain...

Aquatic ecosystem resilience to wildfire can vary widely depending on the characteristics of fire and the spatial context of where a fire takes place. Researchers at EPA&rsquo;s Office of Research and Development are collaborating with the US Forest Service, and Oregon State Univ...

Presentation about research using trail cameras as input data to a neural network machine learning model to inform on streamflow.

Presentation for the Clean Water Act 303(d) training workshop that discusses lessons from data collection at stream and lake Regional Monitoring Network sites. The presentation also covers novel monitoring approaches using trail cameras.

The effect of wildfire on aquatic habitat over time is not well understood, especially in the Pacific Northwest, and relies on the collection of ongoing data over long time periods. In Western Washington, Oregon, and Northern California, the Aquatic and Riparian Effectiveness Mon...

Drinking water nitrate contamination is a significant economic and public health concern in The Great Plains, with few tested best practices for improving source water quality. This project seeks to establish a monitoring framework for quantifying the benefits of soil health prac...

In this LifeNet Health webinar, Dr. Deisenroth introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. He will discuss the US EPA Endocrine Disruptor Screening Program’...

The Equitable Resilience Builder (ERB) is a downloadable application that for enhancing community engagement and equity in resilience planning. The tool provides guidance and activities for assessing community resilience needs and identifying actions. Activities include network m...

Introduction The Integrated Risk Information System (IRIS) assessment for trichloroethylene (TCE) found that human data were sufficient to support dose-response modeling and to develop an inhalation unit risk (IUR) for renal cell carcinoma (RCC). However, human and rodent data su...

This chapter is focused on the reproductive and developmental toxicity of selected environmentally relevant volatile solvents and gasses to which inhalation is a primary route of exposure in humans. Limited data are available regarding the human reproductive and developmental tox...

Within the field of health risk assessment, it is essential that evaluations of reliability or validity of toxicity data are conducted with structure and transparency. To this end, different tools for evaluating toxicity studies have been developed by different groups and organiz...

Physiologically based pharmacokinetic (PBPK) models are commonly used in risk assessments to perform inter- and intraspecies extrapolations as well as to extrapolate between different dosing scenarios; however, they must first undergo quality assurance review, which can be a time...

SAAOP Invited presentation to highlight interoperability of EPA Adverse Outcome Pathway Database (AOP-DB) with the AOP-wiki.

This poster is intended to provide a quick reference for key points of face mask fit and simple modifications that can be made to face masks to improve fit.&nbsp; It is intended to be used in EPA, and potentially other Federal, facilities.

The Adverse Outcome Pathway (AOP) framework has been adopted as means to assemble, organize, and integrate all available biological information to support sound regulatory decision making. Environmental chemicals can interfere with the thyroid system at numerous sites, and these ...

Air pollution is a global environmental and public health issue. Exposure to air pollution is associated with elevated risk of morbidity and mortality from respiratory, cardiovascular, and neurological diseases. Following exposure to air pollution, the lung and other organ system...

Iron determines the abundance and diversity of life and controls primary production in numerous aqueous environments. Over the past decades, the availability of this metal in natural waters has decreased. Iron deficiency can apply a selective pressure on microbial aquatic communi...

The American Heart Association released a scientific statement describing the importance of housing on cardiovascular health and emphasized the impact of the broader physical and social environment. Increased ambient temperature due to climate change and lack of environmental enr...

The use of in vitro systems to model inhalation exposures has focused on using primary cells as they can recapitulate key features of the airway epithelium in vivo.&nbsp; For inhaled chemicals, achieving this goal has relied on using differentiated primary human bronchial epithel...

We demonstrated previously that, on a mass basis, mutagenicity associated with particulate matter (PM) from flaming smoke is greater than smoldering PM. &nbsp;This finding, however, is limited to fresh smoke emissions, which are different from the actual smoke (i.e., photochemica...

Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of chemicals in use and the high rate of drug candidate failure due to toxicity, ...