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The Road From Animal Models to New Approach Methods for Protecting Human and Animal Health &nbsp; Barbara L. F. Kaplan1, Alan M. Hoberman2, William Slikker Jr3, Mary Alice Smith4, Emanuela Corsini5, Thomas B. Knudsen6, M. Sue Marty7, Sonya K. Sobrian8, Suzanne C. Fitzpatrick9, Ma...

The US EPA uses exposure and toxicity information and risk assessments to protect human health and the environment from known hazards. However, some of the chemicals we are exposed to are unknown, undetected, and unregulated. Discovering the identity of unknown chemicals with mas...

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This is a lecture presentation to public health students in the Gilling School of Public Pealth at University of North Carolina at Chapel Hill.

On September 1, 2020, EPA published the final regulation, Use of Lead Free Pipes, Fittings, Fixtures, Solder, and Flux for Drinking Water. EPA made&nbsp; the conforming changes to existing regulations based on the Reduction&nbsp; of Lead in Drinking Water Act of 2011 and the Comm...

Histone deacetylase inhibitors (HDACi) are epigenotoxicants that disrupt gene expression by modulating histone acetylation. We developed a transcriptomic biomarker of HDACi in human TK6 cells to address the limitations in tools available for identifying HDACi in chemical screenin...

Background and Purpose: Time series data for environmentally relevant chemicals in body fluids and tissues after an exposure is rarely made available despite their importance for risk assessment. Further, access to in vivo data is crucial for chemical safety evaluation estimate...

A key part of the problem formulation phase of environmental assessment is the development of conceptual model diagrams. These diagrams, which explicitly illustrate hypothesized pathways between sources, stressors, and responses relevant to the focal issue, are used in scoping an...

Large scale (i.e. continental United States) aquatic resource surveys often collect samples and ship to a centralized processing laboratory. The rigors and chosen methods of shipping and handling as well as holding time could impact the integrity of algal pigments. This study exa...

The National Aquatic Resource Surveys (NARS) program, a collaboration among United States Environmental Protection Agency (US EPA) Office of Water, Office of Research and Development (ORD), and states and tribes, assesses progress towards the objective of the Clean Water Act thro...

EPA-ORD-CPHEA's Michael Pennino and Jana Compton were invited to present on groundwater nitrate at SSWR&rsquo;s Quarterly Research Area Coordination Team (RACT) meeting for the Nutrients topic SSWR.4 on June 5, &nbsp;2024.&nbsp; This meeting brings together the research coordinat...

Diatoms and soft algae have been collected by state monitoring programs across the United States to assess the biological condition of lotic and lentic water bodies. Some of the state programs have long-term records (i.e., decades) of algal taxonomic data. Over time, changes in l...

Taxonomic data are the foundation of bioassessment and much basic and applied research. Difficulty in morphological species identification, evolving and varying taxon concepts, and nomenclatural changes can lead to significant inconsistencies in taxonomic datasets across analysts...

These slides introduce EPA ORD's Living Shorelines public education session for the community of Crisfield, MD, as part of co-development of research on nature-based strategies for coastal resilience. The goal is to help build knowledge capacity around living shoreline functional...

Freshwater ecosystems are exceptionally rich in biodiversity and provide essential benefts to people. Yet they are disproportionately threatened compared to terrestrial and marine systems and remain underrepresented in the scenarios and models used for global environmental assess...

In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the ...

Introduction (120/120): The US EPA is developing new approach methodologies (NAMS) to rapidly evaluate thousands of data-poor chemicals for human health hazards. These NAMs include&nbsp;in vitro exposures to investigate chemical metabolism in novel cell systems to inform hazard a...

Poly- and perfluoroalkyl substances (PFAS) are a large class of halogenated organic compounds (HOCs, also called organohalogens) utilized in a variety of industrial applications. Despite their widespread use in bulk quantities, significant concerns have been raised regarding thei...

During the past century, a vast number of organic chemicals have been manufactured and used in industrial, agricultural, public health, consumer products, and other applications. The widespread use in bulk quantities of halogenated organic chemicals (HOCs; also called as Organoha...

Halogenated organic compounds (HOCs) are long-lived toxic compounds and are of major concern for ecosystem and health. The use and manufacture of several HOCs is banned or phased out in most countries, but some HOCs are still being used in several countries. The levels of certain...

Aquatic ecosystem resilience to wildfire can vary widely depending on the characteristics of fire and the spatial context of where a fire takes place. Researchers at EPA&rsquo;s Office of Research and Development are collaborating with the US Forest Service, and Oregon State Univ...

Presentation about research using trail cameras as input data to a neural network machine learning model to inform on streamflow.

Presentation for the Clean Water Act 303(d) training workshop that discusses lessons from data collection at stream and lake Regional Monitoring Network sites. The presentation also covers novel monitoring approaches using trail cameras.

The effect of wildfire on aquatic habitat over time is not well understood, especially in the Pacific Northwest, and relies on the collection of ongoing data over long time periods. In Western Washington, Oregon, and Northern California, the Aquatic and Riparian Effectiveness Mon...

Drinking water nitrate contamination is a significant economic and public health concern in The Great Plains, with few tested best practices for improving source water quality. This project seeks to establish a monitoring framework for quantifying the benefits of soil health prac...