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The global disease burden resulting from exposure to traffic emissions is a growing worldwide public health threat. Children&mdash;from infancy to the age of 14&mdash; are especially susceptible to the health effects of traffic emissions due to their rapidly developing immune, ne...

Children&rsquo;s consumer products represent an important exposure source for many toxicants. Chemicals of high concern, as designated by the Washington State Child Safe Product Act include phthalates, Bisphenol A (BPA) and parabens, among others. As regulation and reporting requ...

Background: Children are exposed to chemical and non-chemical stressors from their built, natural, and social environments. Research is needed to advance our scientific understanding of non-chemical stressors, evaluate how they alter the biological response to a chemical stressor...

This presentation will summarize the past 20 years of our research in this area. The presentation will demonstrate the application of quantitative PCR in quantifying fungi/molds.

Children may be more vulnerable to the combined interactions of chemical and non-chemical stressors from their built, natural, and social environments when compared to adults. Up to 20% of children are diagnosed with a mental illness annually in the United States with a large num...

As EPA works with its federal partners to better coordinate activities and implement the overall federal effort to reduce childhood lead exposures and associated health impacts, the Agency is continuing its efforts to reduce lead exposures as described under the following goals:G...

Children are exposed to a wide variety of chemical and non-chemical stressors at each lifestage throughout their lifecourse, potentially impacting their lifelong health and well-being. To understand potential chemical exposures, we collect and analyze multimedia (e.g., air, water...

Xenobiotic exposures affect the maternal and/or in utero environment resulting in impairments in fetal development. During the period of rapid fetal growth, underdeveloped cardiovascular systems are especially vulnerable to their environment. Furthermore, fetal exposures can evok...

Cortical heterotopias are characterized as clusters of ectopic neurons in the brain, and are associated with neurodevelopmental disorders like epilepsy and learning disabilities in patients. We have previously characterized the robust penetrance of a heterotopia in a rat model, i...

Boron was last updated on IRIS in the late 1980's . Since that time new studies have provided developmental data in three species. The goal of this updated IRIS file is to re-assess the RfD based on new research and updated methodology, specifically application of the benchmark a...

Childhood cancers are rare conditions whose etiology is poorly understood. There is evidence that for some, the causal pathway may commence in utero or during peri-conception. One traditional epidemiologic approach to the study of rare diseases is the use of a retrospective cas...

EPA released the final report entitled, <i>A Framework for Assessing Health Risk of Environmental Exposures to Children</i>, which examines the impact of potential exposures during developmental lifestages and subsequent lifestages, while emphasizing the iterative nature of the a...

The draft document, <i>Framework For Assessing Health Risks of Environmental Exposure to Children</i>, can serve as a resource on children's health risk assessment and it addresses the need to provide a comprehensive and consistent framework for considering children in risk asses...

We examined influences of asthma and household environment (passive smoking, gas stove use, and having a dog or cat), on seven measures of spirometric lung function in 8-16 yearold subjects, as measured in the Third National Health and Nutrition Examination Survey (NHANES III). ...

The Framework for Children's Health Risk Assessment report can serve as a resource on children's health risk assessment and it addresses the need to provide a comprehensive and consistent framework for considering children in risk assessments at EPA. This framework lays out the ...

Substantial effort has been invested in improving children’s health risk assessment in recent years. However, the body of scientific evidence in support of children’s health assessment is constantly advancing requiring continual updating of risk assessment methods. Children’s i...

During the winter of 1988-1989, parents of 2,789 elementary school students completed standardized questionnaires. The students were 5-14 years of age and were from three urban districts and one suburban district of three large Chinese cities. The 4-y average ambient levels of ...

The importance of including neurodevelopmental end points in environmental studies is clear. A validated measure of cognitive function in human infants that also has a homologous or parallel test in laboratory animal studies will provide a valuable approach for large-scale studie...

The 2017 Annual Meeting of the NIEHS/EPA Children’s Environmental Health and Disease Prevention Research Centers was hosted by EPA in collaboration with NIEHS and the Pediatric Environmental Health Specialty Units (PEHSUs). The meeting was held at the EPA Region 9 offices in San ...

Identifying environmental chemicals that adversely affect children’s health outcomes requires assembling information from a wide variety of sources, particularly from the millions of articles in the biomedical literature. Literature informatics approaches can help researchers ma...

Microphysiological systems (MPS) and computer simulation models that recapitulate the underlying biology and toxicology of critical developmental transitions are emerging tools for developmental effects assessment of drugs/chemicals. Opportunities and challenges exist for their a...

The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites and hormones between vascular and neural compartments. Here, we review the current understanding of BBB development with regard to microphysiology of the neurovascular unit (...

In 1997, EPA and the National Institute of Environmental Health Sciences (NIEHS) partnered to form the Children's Environmental Health and Disease Prevention Research Centers. This impact report summarizes the history of the program, scientific findings since the program's incept...

Abstract for poster presentation

Infants and children are not little adults. They are uniquely vulnerable to environmental toxicants. To protect infants and children against toxicants, the National Research Council in 1993 called for development of an approach to risk assessment that considers children's unique...