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<P>There are reported insecticide residues present in food, water, and surfaces such as carpets treated for flea control. However, no studies (except those we currently have in place) have quantified the transferable flea control insecticide residues which occur on pets (the majo...

Children are the most susceptible population to environmental contaminants since: (a) their organs and neurological system are rapidly developing; (b) their intake (air, water, food, beverage) is greater relative to body size and weight; (c) their activities, behavior and p...

Many pesticides cxause reproductive or developmental toxicity at high doses in animal models, but effects in humans at environmental exposure levels are difficult to assess. Human data on reproductive and developmental outcomes for currently used pesticides may help to define ris...

<p>Overall, these studies are designed to confirm and validate the biomarkers determined in the CCCEH human studies of BPA and PAH exposure and to determine the hypothesized link between epigenetic changes in blood with those determined in brain and adipose tissue to determine th...

<p>We hypothesize that prenatal exposure to PAH and BPA (1) will be associated with higher weight gain trajectories from age 5 to 8-10, and at age 8-10 years with BMI z-score, fat mass and metabolic syndrome components and (2) will alter the methylation status of key genes involv...

Previously we reported an increased incidence of audiogenic seizures in offspring of pregnant rats exposed to an environmental mixture of polychlorinated biphenyls (PCBs). This study compares the proconvulsant properties of PCB exposure in audiogenic and electrical kindling seizu...

Thyroid hormones (TH) play crucial roles in brain maturation, neuronal migration, and neocortical lamination. Subcortical band heterotopia (SBH) represent a class of neuronal migration errors in humans that are often associated with childhood epilepsy. We have previously reported...

Thyroid hormones (TH) are essential for brain development, yet clear indicators of disruption at low levels of TH insufficiency have yet to be identified. Brain TH is difficult to measure, but TH-responsive genes can serve as sensitive indicators of TH action in brain. A large nu...

Pharmacology and toxicology share a common interest in pharmacokinetic data, especially as it is available in pediatric populations. These data have been critical to the clinical pharmacologist for many years in designing age-specific dosing regimens. Now they are being used incr...

<p>This project offers the very distinct advantages of human relevance and enhanced susceptibility in the evaluation of environmental impacts on prostate development. The goal of this pilot project is to build a platform to evaluate the developmental origins of later life prostat...

<p>In Specific Aim 1, we will develop a lung model of in utero arsenic exposure. We will assess the best graft conditions, including size, site and initial stage to ensure optimal graft survival and maturation. In addition, we will study the pharmacokinetic relationship between a...

<div> Project 1:&nbsp; If ongoing experiments indicate that the liver xenotransplants are not surviving, then we will consider options, including transplantation to the surface of the liver to allow for faster and more robust vascularization of the transplanted tissue.&nbsp; In...

<p>We have developed the following specific aims: Specific Aim 1 will be to develop a model and the liver phenotype (defined as above) is maintained. In Specific Aim 2, we will demonstrate that manipulation of the host environment will induce changes in liver tissues. We will exa...

<p>The Children&rsquo;s Environmental Health Center (CEHC) was established in 1998 as a specialized center for investigating the effects of the environment on children&rsquo;s respiratory health with a focus on asthma and allergic airway disease. The theme of the Center and it...

A review of the national ambient air quality standards (NAAQS) for particulate matter (PM) is currently underway. The Criteria Document was completed in October 2004, and a proposed decision to revise the PM NAAQS was published in January 2006. The final decision is to be signe...

<p>We will begin collection from 3,000 children in September of the 2004-2005 school year. &nbsp;We would like to expand the genotyping to include tagSNPs to characterize the haplotype diversity using the Illumina platform after whole genome amplification.</p>

<p>We plan to complete recruitment and the first waves of home air pollution sampling in the coming year, followed by questionnaire administration and buccal cell collection for analysis of polymorphisms.</p>

Ecosystems provide multiple societal benefits from the production of nature-based goods and services. Many ecosystem services have been linked to a range of positive health outcomes through the buffering of pollutants and natural hazards and the promotion of healthy behaviors. A ...

<p>This data will fill key gaps in our understanding of exposure before birth and capacity to detoxify Bisphenol A (BPA) and could inform and strengthen future studies of the effects of BPA and other environmental chemicals on development.</p>

<p>We expect, at the end of this project, to be able to 1) characterize sources of maternal exposure to BPA, the relationship between maternal and intrauterine levels of BPA and 2) gain an in‐depth understanding of BPA affects early development. We anticipate this will improve ou...

<p>Ambient winter concentrations of PM2.5 gradually declined over the study period and were 30% lower in the fi nal winter after the changeout pro - gram (year 4) than in the baseline years. By the end of the study period, Libby was no longer out of compliance with the Natio...

America's Children and the Environment is the U.S. EPA's report of children's environmental health indicators. Two editions of the report have been published, in 2000 and 2003, and a website is maintained with updated values for the indicators. The new Third Edition of America'...

Ecosystems provide multiple services associated with the provision of nature-based goods and services. Many of these ecosystem services have been linked to a range of positive health outcomes through buffering of pollutants, mitigation of natural hazards, and promotion of healthy...

<p>The proposed study is a supplement to our EPA/NIEHS funded Center for Child Environmental Health Risks Research (CHC). We propose to develop an integrative tool for evaluating the importance of knowledge of biomarkers of susceptibility and early response for establishing the e...

<p>Work during the next year will focus on establishing structural and functional correlations between the changes in Eph/ephrin expression and MeHg exposure. We have begun to characterize the cellular expression of the specific molecules using <em>in situ</em> hybridization ...