Science Inventory

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MARTIN, M. T. Validation, acceptance, and extension of a predictive model of reproductive toxicity using ToxCast data. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

BUSTA, E., D. HRISTOZOV, K. ARVIDSON, C. YANG, S. ESPADA, D. MATTHISON, AND M. T. MARTIN. A Developmental Toxicity Database to Support Computational Toxicology; A Collaborative Project for Data Sharing and Harmonization. Presented at Annual Meeting of the Society of Toxicology, Washington, DC, March 06 - 10, 2011.

KNUDSEN, T. B., K. A. HOUCK, N. SIPES, A. V. SINGH, R. JUDSON, M. T. MARTIN, A. WEISSMAN, N. KLEINSTREUER, H. M. MORTENSEN, D. REIF, J. R. RABINOWITZ, R. W. SETZER, A. M. RICHARD, D. J. DIX, AND R. J. KAVLOCK. Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. TOXICOLOGY. Elsevier Ireland Limited, Limerick, Ireland, 282(1-2):1-15, (2011).

WILSON, A., S. GANGWAL, M. T. MARTIN, R. JUDSON, D. J. DIX, AND D. REIF. Assessing the Robustness of Chemical Prioritizations Based on ToxCast Chemical Profiling. Presented at Annual Meeting of the Society of Toxicology, Washington, DC, March 06 - 10, 2011.

PIERSMA, A. H., E. RORIJE, M. E. BEEKHUIJZEN, R. L. COOPER, D. J. DIX, B. HEINRICH-HIRSCH, M. T. MARTIN, E. MENDEZ, A. MULLER, M. PAPARELLA, D. RAMSINGH, E. REAVES, P. RIDGWAY, E. SCHENK, L. STACHIW, B. ULBRICH, AND B. C. HAKKERT. Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 31(4):392-401, (2011).

JUDSON, R., D. J. DIX, R. J. KAVLOCK, R. W. SETZER, E. A. COHEN-HUBAL, AND M. T. MARTIN. Estimating Toxicity Pathway Activating Doses for High Throughput Chemical Risk Assessments. Presented at Annual Meeting of the Society of Toxicology, Washington, DC, March 06 - 10, 2011.

JUDSON, R., R. J. KAVLOCK, R. W. SETZER, E. A. COHEN-HUBAL, M. T. MARTIN, T. B. KNUDSEN, K. A. HOUCK, R. S. THOMAS, B. A. WETMORE, AND D. J. DIX. Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 24(4):451-462, (2011).

TLUCZKIEWICZ, I. I., H. E. BUIST, M. T. MARTIN, I. MANGELSDORF, AND S. E. ESCHER. Improvement of the Cramer classification for oral exposure using the database TTC RepDose - A strategy description. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science BV, Amsterdam, Netherlands, 61(3):340-350, (2011).

MARTIN, M. T., T. B. KNUDSEN, K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Modeling Reproductive Toxicity for Chemical Prioritization into an Integrated Testing Strategy. Presented at Annual Meeting of the Society of Toxicology, Washington, DC, March 06 - 10, 2011.

MARTIN, M. T., T. B. KNUDSEN, D. REIF, K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening. BIOLOGY OF REPRODUCTION. Society for the Study of Reproduction, 85(2):327-339, (2011).

SIPES, N., M. T. MARTIN, D. REIF, N. KLEINSTREUER, S. J. PADILLA, M. ROUNTREE, A. V. SINGH, K. J. CHANDLER, R. JUDSON, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Predictive Modeling of Developmental Toxicity. Presented at 51st Annual Meeting of the Teratology Society, Coronado, CA, June 25 - 29, 2011.

SIPES, N. S., M. T. MARTIN, D. M. REIF, N. C. KLEINSTREUER, R. S. JUDSON, A. V. SINGH, K. J. CHANDLER, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 124(1):109-127, (2011).

REIF, D., M. T. MARTIN, H. M. MORTENSEN, S. GANGWAL, A. WANG, R. JUDSON, P. VOLARATH, R. J. KAVLOCK, AND D. J. DIX. Prioritizing ToxCast Chemicals Across Multiple Sectors of Toxicity Using ToxPi. Presented at Annual Meeting of the Society of Toxicology, Washington, DC, March 06 - 10, 2011.

SIPES, N., M. T. MARTIN, D. REIF, N. KLEINSTREUER, R. JUDSON, A. V. SINGH, K. J. CHANDLER, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Probing the ToxCastTM Chemical Library for Predictive Signatures of Developmental Toxicity - Poster at Teratology Society Annual Meeting. Presented at 51st Annual meeting of the Teratology Society, Coronado, CA, June 25 - 29, 2011.

SIPES, N., M. T. MARTIN, D. REIF, N. KLEINSTREUER, R. JUDSON, A. V. SINGH, K. J. CHANDLER, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Probing the ToxCastTM Chemical Library for Predictive Signatures of Developmental Toxicity -NLTO Poster. Presented at Networking and Leadership Training Organization (NLTO), USEPA, RTP, NC, May 31, 2011.

JUDSON, R., E. A. COHEN-HUBAL, K. A. HOUCK, AND M. T. MARTIN. Release of ToxCastDB and ExpoCastDB databases. U.S. Environmental Protection Agency, Washington, DC, 2011.

SHAH, I. A., A. V. SINGH, C. HAUGH, J. JACK, R. JUDSON, T. B. KNUDSEN, M. T. MARTIN, AND J. F. WAMBAUGH. ToxPlorerTM: A Comprehensive Knowledgebase of Toxicity Pathways Using Ontology-driven Information Extraction. Presented at Annual Meeting of the Society of Toxicology, Washington, DC, March 06 - 10, 2011.

SHAH, I. A., K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, M. T. MARTIN, D. REIF, J. F. WAMBAUGH, AND D. J. DIX. Using Nuclear Receptor Activity to Stratify Hepatocarcinogens. Stefan Wolfl (ed.), PLOS ONE . Public Library of Science, San Francisco, CA, 6(2; (e14584)):1-11, (2011).

JUDSON, R., M. T. MARTIN, D. REIF, K. A. HOUCK, T. B. KNUDSEN, D. ROTROFF, M. XIA, S. SAKAMURU, R. HUANG, P. SHINN, C. P. AUSTIN, R. J. KAVLOCK, AND D. J. DIX. Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 44(15):5979-5985, (2010).

SHAH, I. A., D. WOLF, K. A. HOUCK, R. JUDSON, J. JACK, J. F. WAMBAUGH, M. T. MARTIN, AND C. CORTON. Application of an in silico liver model to determine nuclear receptor mediated pathways in liver cancer . Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.

Beam, A., M. T. MARTIN, D. REIF, D. J. DIX, AND R. JUDSON. Deriving Signatures of In Vivo Toxicity Using Both Efficacy and Potency Information from In Vitro Assays: Evaluating Model Performance as a Function of Increasing Variability in Experimental Data. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.

MARTIN, M. T., T. MCMAHON, T. LEIGHTON, P. SHAH, D. REIF, K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Developing Methods Using ToxCast Data for the Classification and Prioritization of Antimicrobials and Inerts. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.

REIF, D., M. T. MARTIN, S. TAN, K. A. HOUCK, R. JUDSON, A. M. RICHARD, T. B. KNUDSEN, D. J. DIX, AND R. J. KAVLOCK. Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 118(12):2-8, (2010).

VOLARATH, P., S. LITTLE, C. YANG, M. T. MARTIN, D. REIF, AND A. M. RICHARD. Feature Analysis of ToxCast Compounds. Presented at American Chemical Society Fall Meeting, Boston, MA, August 21 - 25, 2010.

REIF, D., K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, T. B. KNUDSEN, M. T. MARTIN, A. M. RICHARD, I. A. SHAH, T. CARPENTER, AND D. J. DIX. High Throughput Prioritization for Integrated Toxicity Testing Based on ToxCast Chemical Profiling. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.