Science Inventory

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Gilbert, M., K. Crofton, K. Paul-Friedman, J. Haselman, S. Degitz, M. Hornung, D. Knapen, L. Vergauwen, E. Stinckens, S. Marty, R. Zoeller, AND B. Demeniex. A Network of AOPs for reduced thyroid hormone synthesis derived from inhibition of Thyroperoxidase - A common Molecular Initiating Event Leading to Species-Specific Indices of Adversity. U.S. EPA Office of Research and Development, Washington, DC, 2016.

Haselman, J., M. Sakurai, N. Watanabe, Y. Goto, Y. Onishi, Y. Ito, Y. Onoda, Pat Kosian, Joe Korte, R. Johnson, T. Iguchi, AND S. Degitz. Development of the larval amphibian growth and development assay: Effects of benzophenone-2 exposure in Xenopus laevis from embryo to juvenile. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(12):1651-1661, (2016).

Haselman, J., Pat Kosian, Joe Korte, A. Olmstead, T. Iguchi, R. Johnson, AND S. Degitz. Development of the larval amphibian growth and development assay: Effects of chronic 4-tert-octylphenol or 17ß-trenbolone exposure in Xenopus laevis from embryo to juvenile. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36(12):1639-1650, (2016).

Kosian, Pat, Joe Korte, J. Haselman, M. Hornung, M. Hotchkiss, AND M. Gilbert. Analysis of thyroid hormones in gland and serum using liquid chromatography-tandem mass spectrometry. MWSETAC/SOT Meeting, Duluth, MN, March 09 - 11, 2015.

Haselman, J., A. Olmstead, AND S. Degitz. Global gene expression during early differentiation of Xenopus (Silurana) tropicalis gonad tissues. GENERAL AND COMPARATIVE ENDOCRINOLOGY. Academic Press Incorporated, Orlando, FL, 214:103-113, (2015).

Hornung, M., Pat Kosian, J. Haselman, Joe Korte, K. Challis, C. Macherla, E. Nevalainen, AND S. Degitz. In vitro, ex vivo, and in vivo determination of thyroid hormone modulating activity of benzothiazoles. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 146(2):254-264, (2015).

Haselman, J., Pat Kosian, Joe Korte, A. Olmstead, R. Johnson, AND S. Degitz. Xenopus laevis Müllerian ducts are sensitive indicators of estrogenic or androgenic chemical exposure in vivo. Society of Toxicology, San Diego, CA, March 22 - 26, 2015.

Haselman, J., Pat Kosian, Joe Korte, A. Olmstead, R. Johnson, AND S. Degitz. Xenopus laevis Müllerian ducts are sensitive indicators of estrogenic or androgenic chemical exposure in vivo (poster presentation). MWSETAC/SOT Meeting, Duluth, MN, March 09 - 11, 2015.

Nichols, J., M. Hornung, Joe Korte, J. Haselman, Joe Tietge, AND S. Degitz. A quantitative adverse outcome pathway model for thyroid axis disruption in Xenopus laevis tadpoles. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.

Hornung, M., J. Haselman, Joe Korte, Pat Kosian, K. Challis, S. Hall, AND S. Degitz. Comparison of in vitro and ex vivo thyroid hormone synthesis inhibition results and in vivo outcomes for a series of benzothiazoles. Presented at Society of Toxicology, Phoenix, AZ, March 24 - 27, 2014.

Johnson, R., S. Degitz, K. Flynn, D. Lothenbach, D. Hammermeister, F. Whiteman, Joe Korte, J. Haselman, AND Pat Kosian. EDSP Tier 2 test (T2T) guidances and protocols are delivered, including web-based guidance for diagnosing and scoring, and evaluating EDC-induced pathology in fish and amphibian. U.S. Environmental Protection Agency, Washington, DC, 2014.

Haselman, Jonathan AND S. Degitz. Overview of EDSP Tier II Larval Amphibian Growth and Development Assay histopathology and statistics. Presented at EDSP Tier 2 histopathology statistics workshop, Rosslyn, VA, December 09 - 12, 2013.

Haselman, J. Progress in development of the Tier II Larval Amphibian Growth and Development Assay. Presented at U.S. Japan 9th Bilateral, Washington DC, October 23 - 24, 2013.

Eid, E., Joe Korte, Pat Kosian, L. Dahlin, J. Haselman, S. Hall, AND S. Degitz. Use of a 48 hour static renewal assay for evaluating UGT gene induction in X. tropicalis. Presented at Society of Environmental Toxicology and Chemistry, March 19 - 20, 2013.

Blanksma, C., A. Olmstead, S. Degitz, J. Haselman, AND R. Johnson. Histological development of the gonad in juvenile Xenopus laevis. Presented at Society for Environmental Toxicology and Chemistry, March 20 - 21, 2012.

TIETGE, J. E., S. J. DEGITZ, J. HASELMAN, B. C. BUTTERWORTH, J. J. KORTE, P. A. KOSIAN, A. LINDBERG-LIVINGSTON, E. M. BURGESS, P. BLACKSHEAR, AND M. HORNUNG. Inhibition of the Thyroid Hormone Pathway in Xenopus laevis by 2-mercaptobenzothiazole. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 126:128-136, (2012).

OLMSTEAD, A. W., P. A. KOSIAN, R. D. JOHNSON, P. BLACKSHEAR, J. HASELMAN, C. BLANKSMA, J. J. KORTE, G. W. HOLCOMBE, E. BURGESS, A. LINDBERG-LIVINGSTON, B. BENNETT, K. K. WOODIS, AND S. J. DEGITZ. Trenbolone causes mortality and altered sexual differentiation in Xenopus topicalis during larval development . ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 31(10):2391-2398, (2012).

HORNUNG, M. W., S. J. DEGITZ, J. E. TIETGE, J. J. KORTE, J. HASELMAN, P. A. KOSIAN, A. J. LINDBERG-LIVINGSTON, AND E. M. BURGESS. A Pathway Approach to Predicting Thyroid Hormone Disrupting Activity of Chemicals Using in vitro, ex vivo and in vivo Assays. Presented at International Symposium on Amphibian Endocrinology and Neurobiology, Ann Arbor, MI, July 11 - 13, 2011.

OLMSTEAD, A. W., L. S. BLAKE, P. A. KOSIAN, J. HASELMAN, J. J. KORTE, R. D. JOHNSON, C. BLANKSMA, K. LILLEGARD, S. ZAVODNIK, B. HEGGESTAD, AND S. J. DEGITZ. Assessment of the Endocrine Toxicity of the Fungicide Prochloraz using the Larval Amphibian Growth and Development Assay. Presented at Society of Environmental Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.

OLMSTEAD, A. W., P. A. KOSIAN, R. D. JOHNSON, J. HASELMAN, AND S. J. DEGITZ. Endocrine Toxicity of Trenbolone During Larval Development of Xenopus tropicalis. Presented at International Symposium on Amphibian Endocrinology and Neurobiology , Ann Arbor, MI, July 11 - 13, 2011.

HASELMAN, J., A. W. OLMSTEAD, AND S. J. DEGITZ. Identification of Gender-specific Transcripts by Microarray in Gonad Tissue of Larval and Juvenile Xenopus tropicalis. Presented at International Symposium on Amphibian Endocrinology and Neurobiology (ISAREN), Ann Arbor, MI, July 11 - 13, 2011.

TIETGE, J. E., B. C. BUTTERWORTH, J. HASELMAN, G. W. HOLCOMBE, M. HORNUNG, J. J. KORTE, P. A. KOSIAN, S. J. DEGITZ, AND M. WOLFE. Early Temporal Effects of Three Thyroid Hormone Synthesis Inhibitors in Xenopus laevis. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 98(1):44-50, (2010).

OLMSTEAD, A. W., P. A. KOSIAN, L. BLAKE, J. HASELMAN, J. J. KORTE, G. W. HOLCOMBE, AND S. J. DEGITZ. Endocrine Toxicity of Trenbolone in the Western Clawed Frog, Xenopus (Silurana) tropicalis. Presented at SETAC North America 31st Annual Meeting, Portland, OR, November 07 - 11, 2010.

HORNUNG, M. W., J. HASELMAN, G. W. HOLCOMBE, J. J. KORTE, L. KORTE, E. BURGESS, B. C. BUTTERWORTH, P. A. KOSIAN, J. A. SERRANO, J. E. TIETGE, AND S. J. DEGITZ. Interpreting in vivo Effects of Thyroid Synthesis Inhibitors through the Lens of in vitro and ex vivo Assays. Presented at 35th Annual Aquatic Toxicity Workshop, Saskatoon, SK, CANADA, October 05 - 08, 2008.

HASELMAN, J., J. E. TIETGE, M. W. HORNUNG, AND S. J. DEGITZ. Development of a High-throughput Method for Quantitating Thyroid Gland Folllicular Cell Hyperplasia in Amphibian Model Species Xenopus laevis. Presented at SETAC Annual Meeting, Milwaukee, WI, November 11 - 15, 2007.