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Records 26 to 50 of 60 records from author Patrick Fitzsimmons

2011
CONNORS, K. A., B. DU, P. N. FITZSIMMONS, C. K. CHAMBLISS, J. W. NICHOLS, AND B. W. BROOKS. Comparative Pharmaceutical Metabolism with Rainbow Trout (Oncorhychus mykiss) S9. Presented at Society for Environmental Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.
NICHOLS, J. W., A. D. HOFFMAN, P. N. FITZSIMMONS, K. A. FAY, AND T. TER LAAK. Hepatic Clearance of Six Polyaromatic Hydrocarbons by Isolated Perfused Trout Livers: Prediction from Liver S9 Fractions and Isolated Hepatocyte. Presented at pollutant responses in marine organisms, Long Beach, CA, May 15 - 18, 2012.
FAY, K., P. N. FITZSIMMONS, A. D. HOFFMAN, AND J. W. NICHOLS. Use of Isolated Trout Hepatocytes to Predict Measured Hepatic Clearance and Whole-animal Bioconcentration Factors for Six Polyaromatic Hydrocarbons. Presented at Society of Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.
2010
FITZSIMMONS, P. N., A. D. HOFFMAN, AND J. W. NICHOLS. Effect of Gender on Intrinsic Clearance of Six Polyaromatic Hydrocarbons by Liver S9 Fractions from Sexually Immature Rainbow Trout. Presented at Society for Environmental Toxicology and Chemistry, Portland, OR, November 07 - 11, 2010.
NICHOLS, J. W., A. D. HOFFMAN, T. TER LAAK, AND P. N. FITZSIMMONS. Hepatic Clearance of Six Polyaromatic Hydrocarbons by Isolated Perfused Trout Livers: Evaluation of Protein Binding Effects. Presented at Society for Environmental Toxicology and Chemistry, Portland, OR, November 07 - 11, 2011.
2009
HOFFMAN, A. D., T. L. TER LAAK, P. N. FITZSIMMONS, AND J. W. NICHOLS. An Evaluation of the Venous Equilibrium Model for Hepatic Clearance using Isolated Perfused Rainbow Trout Livers. Presented at SOT Annual Meeting, Baltimore, MD, March 15 - 19, 2009.
FITZSIMMONS, P. N., A. D. HOFFMAN, A. D. HOFFMAN, G. J. LIEN, D. E. HAMMERMEISTER, AND J. W. NICHOLS. Kinetics and Effects of Dichloroacetic Acid in Rainbow Trout. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 94(3):186-194, (2009).
NICHOLS, J. W., G. J. LIEN, A. D. HOFFMAN, AND P. N. FITZSIMMONS. Metabolism of 7-ethyoxycoumarin by Isolated Perfused Rainbow Trout Livers. Presented at SOT Annual Meeting, Baltimore, MD, March 15 - 19, 2009.
NICHOLS, J. W., A. D. HOFFMAN, AND P. N. FITZSIMMONS. Optimization of an Isolated Perfused Rainbow Trout Liver Model: Clearance Studies with 7-Ethoxycoumarin. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 95(3):182-194, (2009).
2008
NICHOLS, J. W., A. D. HOFFMAN, P. N. FITZSIMMONS, AND G. J. LIEN. Quantification of Phenol, Phenyl Glucuronide, and Phenyl Sulfate in Blood of Unanesthetized Rainbow Trout by On-line Microdialysis Sampling. Toxicology Mechanisms and Methods. Taylor & Francis, Inc., Philadelphia, PA, 18:405-412, (2008).
2007
FITZSIMMONS, P. N., G. J. LIEN, AND J. W. NICHOLS. A Compilation of In Vitro Rate and Affinity Values for Xenobiotic Biotransformation in Fish, Measured Under Physiological Conditions. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. Elsevier Science Ltd, New York, NY, Part C 145:485-506, (2007).
NICHOLS, J. W., P. N. FITZSIMMONS, AND L. P. BURKHARD. In Vitro-In Vivo Extrapolation of Quantitative Hepatic Biotransformation Data for Fish: II. Modeled Effects on Chemical Bioaccumulation. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 26(6):1304-1319, (2007).
HORNUNG, M. W., P. M. COOK, P. N. FITZSIMMONS, D. W. KUEHL, AND J. W. NICHOLS. Tissue Distribution and Metabolism of Benzo[a]pyrene in Embryonic and Larval Medaka Oryzias Latipes. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 100(2):393-405, (2007).
2006
NICHOLS, J. W., I. R. SCHULTZ, AND P. N. FITZSIMMONS. In vitro-in vivo Quantitative Extrapolation of Hepatic Metabolism Data for Fish: A Review of Methods and Strategies for Incorporating Intrinsic Clearance Estimates into Chemical Kinetic Models. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 78(2006):74-90, (2006).
2005
NICHOLS, J. W., P. N. FITZSIMMONS, AND L. P. BURKHARD. IN VITRO-IN VIVO EXTRAPOLATION OF HEPATIC BIOTRANSFORMATION DATA FOR FISH: MODELED EFFECTS ON CHEMICAL BIOACCUMULATION. Presented at SETAC Annual Meeting, Baltimore, MD, November 13 - 17, 2005.
Fitzsimmons, P N. AND J. W. Nichols. KINETICS AND SCALING OF METABOLIC BIOTRANSFORMATION IN FISH: A COMPILATION OF RATE AND AFFINITY VALUES MEASURED UNDER PHYSIOLOGICAL CONDITIONS. Presented at Society of Toxicology 2005 Annual Meeting, New Orleans, LA, March 06 - 10, 2005.
Nichols, J. W. AND P N. Fitzsimmons. KINETICS AND SCALING OF METABOLIC BIOTRANSFORMATION IN FISH: EFFECTS ON BIOACCUMULATION PREDICTED BY INCORPORATING IN VITRO DATA INTO TWO KINETIC MODELS. Presented at Society of Toxicology 2005 Annual Meeting, New Orleans, LA, March 6-10, 2005.
NICHOLS, J. W., A. D. HOFFMAN, P. N. FITZSIMMONS, AND G. J. LIEN. USE OF ON-LINE INJECTION MICRODIALYSIS TO DETERMINE THE RATE OF PHENOL GLUCURONIDATION IN UNANESTHETIZED RAINBOW TROUT. Presented at SETAC Annual Meeting, Baltimore, MD, November 13 - 14, 2005.
Hornung, M. W., P. N. FITZSIMMONS, D. W. KUEHL, R. D. Johnson, P. M. Cook, AND J. W. Nichols. VISUALIZATION OF TISSUE DISTRIBUTION AND METABOLISM OF BENZO[A]PYRENE IN EARLY EMBRYONIC MEDAKA (ORYZIAS LATIPES). Presented at Society of Toxicology (SOT) Annual Meeting, New Orleans, LA, March 06 - 10, 2005.
2004
Nichols, J. W., P N. Fitzsimmons, F W. Whiteman, T D. Dawson, L. Babeu, AND J. A. Juenemann. A PHYSIOLOGICALLY BASED TOXICOKINETIC MODEL FOR DIETARY UPTAKE OF HYDROPHOBIC ORGANIC COMPOUNDS BY FISH: I. FEEDING STUDIES WITH 2,2',5,5'-TETRACHLOROBIPHENYL. TOXICOLOGICAL SCIENCES 77(2):206-218, (2004).
Nichols, J. W., P N. Fitzsimmons, AND F W. Whiteman. A PHYSIOLOGICALLY BASED TOXICOKINETIC MODEL FOR DIETARY UPTAKE OF HYDROPHOBIC ORGANIC COMPOUNDS IN FISH: II. SIMULATION OF CHRONIC EXPOSURE SCENARIOS. TOXICOLOGICAL SCIENCES 77(2):219-229, (2004).
2003
Kolanczyk, R C., P N. Fitzsimmons, J M. McKim, R J. Erickson, AND P. K. Schmieder. EFFECTS OF ANESTHESIA (TRICAINE METHANESULFONATE, MS-222) BIOTRANSFORMATION IN RAINBOW TROUT (ONCORHYNCHUS MYKISS). AQUATIC TOXICOLOGY. Elsevier Science BV, Amsterdam, Netherlands, 64:177-184, (2003).
2002
Johnson, R. D., D B. Lothenbach, K. M. Flynn, D. F. Hammermeister, F W. Whiteman, P N. Fitzsimmons, P. K. Schmieder, A Deangelo, D C. Wolf, J W. Fournie, W W. Walker, R. N. Winn, AND M. J. Wolfe. A SMALL FISH MULTI-ENDPOINT BIOASSAY FOR ASSESSING THE EFFECTS OF WATER CONTAMINANTS PRESENT IN LOW CONCENTRATIONS: MEDAKA AND DICHLOROACETIC ACID. Presented at USEPA Science Forum 2002: Meeting the Challenges, Washington, DC, May 1, 2002.
Lothenbach, D B., K. M. Flynn, R. D. Johnson, P N. Fitzsimmons, D E. Hammermeister, F W. Whiteman, AND P. K. Schmieder. SMALL FISH MULTI-ENDPOINT BIOASSAY DEVELOPMENT. Presented at Joint Annual Meeting of SETAC/SOT Northland Chapter, USEPA, Duluth, MN, April 9-10, 2002.
Fitzsimmons, P N., A D. Hoffman, D E. Hammermeister, G J. Lien, AND J. W. Nichols. UPTAKE AND ELIMINATION OF DICHLOROACETIC ACID BY RAINBOW TROUT. Presented at 2002 SETAC Annual Meeting, Salt Lake City, UT, November 16-20, 2002.