Science Inventory

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Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Use of isolated hepatocytes to predict measured hepatic clearance of five polyaromatic hydrocarbons by perfused trout livers, invited presentation. Presented at Toxicology Graduate Student Seminar, October 03, 2012.

NICHOLS, J. W., R. BENNETT, R. ROSSMANN, J. B. FRENCH, AND K. G. SAPPINGTON. A Physiologically-based Model for Methylmercury Uptake and Accumulation in Female American Kestrels . Presented at Raptor Research Foundation Conference, Duluth, MN, October 05 - 09, 2011.

CONNORS, K. A., B. DU, P. N. FITZSIMMONS, C. K. CHAMBLISS, J. W. NICHOLS, AND B. W. BROOKS. Comparative Pharmaceutical Metabolism with Rainbow Trout (Oncorhychus mykiss) S9. Presented at Society for Environmental Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.

NICHOLS, J. W., A. D. HOFFMAN, P. N. FITZSIMMONS, K. A. FAY, AND T. TER LAAK. Hepatic Clearance of Six Polyaromatic Hydrocarbons by Isolated Perfused Trout Livers: Prediction from Liver S9 Fractions and Isolated Hepatocyte. Presented at pollutant responses in marine organisms, Long Beach, CA, May 15 - 18, 2012.

BONNELL, M., C. COWAN-ELLSBERRY, J. DOMORADZKI, M. EMBRY, S. ERHARDT, M. HALDER, J. W. NICHOLS, AND H. SEGNER. Moving Bioaccumulation Assessments to the Next Level: Progress Made and Challenges Ahead. Presented at Society for Environmental Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.

ESCHER, B., C. COWAN-ELLSBERRY, S. DYER, M. R. EMBRY, S. ERHARDT, M. HALDER, J. KWON, K. JOHANNING, M. T. OOSTERWIJK, S. RUTISHAUSER, H. SEGNER, AND J. W. NICHOLS. Protein and Lipid Binding Parameters in Rainbow Trout (Oncorhynchus mykiss) Blood and Liver Fractions to Extrapolate from an in Vitro metabolic Degradation Assay to in Vivo Bioaccumulation Potential of Hydrophobic Organic Chemicals. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 24(7):1134-1143, (2011).

FAY, K., P. N. FITZSIMMONS, A. D. HOFFMAN, AND J. W. NICHOLS. Use of Isolated Trout Hepatocytes to Predict Measured Hepatic Clearance and Whole-animal Bioconcentration Factors for Six Polyaromatic Hydrocarbons. Presented at Society of Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.

NICHOLS, J. W., R. S. BENNETT, R. ROSSMANN, J. B. FRENCH, AND K. G. SAPPINGTON. A Physiologically Based Model for Methylmercury in Female American Kestrels. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 29(8):1854-1867, (2010).

BENNETT, R. S., R. J. ERICKSON, D. HOFF, M. W. HORNUNG, R. D. JOHNSON, D. R. MOUNT, J. W. NICHOLS, C. L. RUSSOM, P. K. SCHMIEDER, J. A. SERRANO, J. E. TIETGE, AND D. L. VILLENEUVE. Adverse Outcome Pathways: A Conceptual Framework to Support Ecotoxicology Research and Risk Assessment. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 29(3):730-741, (2010).

FITZSIMMONS, P. N., A. D. HOFFMAN, AND J. W. NICHOLS. Effect of Gender on Intrinsic Clearance of Six Polyaromatic Hydrocarbons by Liver S9 Fractions from Sexually Immature Rainbow Trout. Presented at Society for Environmental Toxicology and Chemistry, Portland, OR, November 07 - 11, 2010.

COWAN-ELLSBERRY, C., M. EMBRY, M. J. BERNHARD, S. D. DYER, B. ESCHER, K. JOHANNING, J. W. NICHOLS, AND D. HUGGETT. Extrapolation of BCF from the in vitro Rainbow Trout (Oncorhynchus mykiss) Liver S9 Metabolic Assay Results. Presented at Society for Environmental Toxicology and Chemistry, Portland, OR, November 07 - 11, 2010.

NICHOLS, J. W., A. D. HOFFMAN, T. TER LAAK, AND P. N. FITZSIMMONS. Hepatic Clearance of Six Polyaromatic Hydrocarbons by Isolated Perfused Trout Livers: Evaluation of Protein Binding Effects. Presented at Society for Environmental Toxicology and Chemistry, Portland, OR, November 07 - 11, 2011.

EMBRY, M., A. ADEKOLA, M. J. BERNHARD, C. COWAN-ELLSBERRY, S. DYER, C. EICKHOFF, S. ERHARDT, B. ESCHER, M. HALDER, G. HANCOCK, K. JOHANNING, J. W. NICHOLS, AND A. SHARPE. Validation of the in vitro Rainbow Trout (Oncorhynchus mykiss) Liver S9 Metabolic Assay to Assess Bioaccumulation Potential of Chemicals. Presented at Society for Environmental Toxicology and Chemistry, Portland, OR, November 07 - 11, 2010.

HORNUNG, M. W., G. T. ANKLEY, R. S. BENNETT, R. J. ERICKSON, D. HOFF, R. D. JOHNSON, D. R. MOUNT, J. W. NICHOLS, C. L. RUSSOM, P. K. SCHMIEDER, J. A. SERRANO, J. E. TIETGE, AND D. L. VILLENEUVE. Adverse Outcome Pathways: A Conceptual Framework to Support Ecotoxicology Research and Risk Assessment . Presented at 30th Annual Meeting of SETAC North America, New Orleans, LA, November 19 - 23, 2009.

HOFFMAN, A. D., T. L. TER LAAK, P. N. FITZSIMMONS, AND J. W. NICHOLS. An Evaluation of the Venous Equilibrium Model for Hepatic Clearance using Isolated Perfused Rainbow Trout Livers. Presented at SOT Annual Meeting, Baltimore, MD, March 15 - 19, 2009.

NICHOLS, J. W., M. BONNELL, S. D. DIMITROV, B. ESCHER, X. HAN, AND N. I. KRAMER. Bioaccumulation Assessment using Predictive Approaches. Integrated Environmental Assessment and Management. Allen Press, Inc., Lawrence, KS, 5(4):577-597, (2009).

FITZSIMMONS, P. N., A. D. HOFFMAN, A. D. HOFFMAN, G. J. LIEN, D. E. HAMMERMEISTER, AND J. W. NICHOLS. Kinetics and Effects of Dichloroacetic Acid in Rainbow Trout. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 94(3):186-194, (2009).

NICHOLS, J. W., G. J. LIEN, A. D. HOFFMAN, AND P. N. FITZSIMMONS. Metabolism of 7-ethyoxycoumarin by Isolated Perfused Rainbow Trout Livers. Presented at SOT Annual Meeting, Baltimore, MD, March 15 - 19, 2009.

NICHOLS, J. W., A. D. HOFFMAN, AND P. N. FITZSIMMONS. Optimization of an Isolated Perfused Rainbow Trout Liver Model: Clearance Studies with 7-Ethoxycoumarin. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 95(3):182-194, (2009).

DIAMOND, S. A., D. UTTERBACK, C. P. ANDERSEN, R. M. BURGESS, S. HIRANO, K. T. HO, C. INGERSOLL, M. G. JOHNSON, A. J. KENNEDY, D. R. MOUNT, J. W. NICHOLS, P. PANDARD, P. T. RYGIEWICZ, J. J. SCOTT-FORDSMAND, AND K. STEWART. Review of OECD/OPPTS-harmonized and OPPTS ecotoxicity test guidelines for their applicability to manufactured nanomaterials. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-09/065, 2009.

NICHOLS, J. W., M. BREEN, R. DENVER, J. DI STEFANO III, J. EDWARDS, R. HOKE, D. VOLZ, AND X. ZHANG. Testing and Risk Assessment of Chemicals that Impact Highly Adaptive Biological Systems: The Case of Endocrine Systems. Presented at 30th Annual Meeting of SETAC North America, New Orleans, LA, November 19 - 23, 2009.

EDWARDS, S. W., J. PRESTON, A. GELLER, A. M. JARABEK, D. C. WOLF, E. A. COHEN-HUBAL, G. T. ANKLEY, H. A. EL-MASRI, I. A. SHAH, J. R. FOWLE, J. A. ROSS, J. W. NICHOLS, K. M. CROFTON, M. J. DEVITO, T. V. RAMABHADRAN, R. J. KAVLOCK, E. S. HUNTER, T. B. KNUDSEN, AND W. R. MUNDY. Toxicity pathway-based mode of action modeling for risk assessment. Presented at Symposium on toxicity pathway-based risk assessment, washington dc, DC, May 11 - 13, 2009.

Erickson, J. D., J W. Nichols, P M. Cook, AND G T. Ankley. BIOAVAILABILITY OF CHEMICAL CONTAMINANTS IN AQUATIC SYSTEMS. Chapter 2, R.T. DiGiulio and D.E. Hinton (ed.), Technology of Fishes. CRC Press - Taylor & Francis Group, LLC, Boca Raton, FL, , 9-54, (2008).

NICHOLS, J. W., A. D. HOFFMAN, P. N. FITZSIMMONS, AND G. J. LIEN. Quantification of Phenol, Phenyl Glucuronide, and Phenyl Sulfate in Blood of Unanesthetized Rainbow Trout by On-line Microdialysis Sampling. Toxicology Mechanisms and Methods. Taylor & Francis, Inc., Philadelphia, PA, 18:405-412, (2008).

KLEINOW, K. M., J. W. NICHOLS, W. L. HAYTON, J. M. MCKIM, AND M. G. BARRON. Toxicokinetics in Fishes. Chapter 3, Di Giulio, Richard T. and David E. Hinton (ed.), The Toxicology of Fishes. CRC Press - Taylor & Francis Group, LLC, Boca Raton, FL, , 55-152, (2008).