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Records 51 to
75
of 131 records from author John Nichols
2016
Chen, Y., J. Hermens, M. Jonkers, J. Arnot, J. Armitage, T. Brown, J. Nichols, K. Fay, AND S. Droge. Which molecular features affect the intrinsic hepatic clearance rate of ionizable organic chemicals in fish? ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50:12722-12730, (2016).
2015
Nichols, J. Frontiers of chemical bioaccumulation modeling with fish. UMD Seminar, Duluth, MN, March 27, 2015.
Fay, K., M. Embry, M. Bernard, I. Bischof, J. Davis, J. Domoradzki, M. Halder, X. Han, K. Johanning, H. Laue, D. Nabb, J. Nichols, C. Schlechtriem, H. Segner, L. van der Wal, AND J. Weeks. In vitro to In vivo extrapolation of hepatic metabolism in fish: An inter-laboratory comparison of In vitro methods. SETAC North America, Salt Lake City, UT, November 01 - 05, 2015.
Nichols, J., B. Du, R. Erickson, A. Hoffman, J. Berninger, C. Chambliss, K. Connors, AND B. Brooks. Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, by fathead minnows. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 34(6):1425-1435, (2015).
Nichols, J., F. Gobas, M. McLeod, K. Borgi, P. Leonards, P. Ester, H. Laue, AND J. Arnot. Summary of Cefic-LRI sponsored workshop: Recent scientific developments in bioaccumulation research. In Proceedings, Cefic-LRI-Field Research, Helsinki, FINLAND, September 24, 2014. Cefic, Brussels, Belgium, 1-13, (2015).
2014
Nichols, J., M. Hornung, Joe Korte, J. Haselman, Joe Tietge, AND S. Degitz. A quantitative adverse outcome pathway model for thyroid axis disruption in Xenopus laevis tadpoles. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.
Armitage, J., G. Rattray, AND J. Nichols. Experts Workshop on the Ecotoxicological Risk Assessment of Ionizable Organic Chemicals: Bioaccumulation/ADME. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.
Gouin, T., B. Brooks, M. Bonnell, J. Armitage, B. Escher, T. Henry, M. Lam, J. Nichols, G. Rattray, G. Stringer, T. Valenti, AND M. Embry. Experts workshop on the ecotoxicological risk assessment of ionizable organic chemicals: Towards a science-based framework for chemical assessment. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.
Fay, K., R. Mingoia, I. Goeritz, D. Nabb, A. Hoffman, B. Ferrell, H. Peterson, J. Nichols, H. Segner, AND X. Han. Intra- and inter-laboratory reliability of a cryopreserved trout hepatocyte assay for the prediction of chemical bioaccumulation potential. ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 48(14):8170-8178, (2014).
Connors, K., B. Du, P. Fitzsimmons, K. Chambliss, J. Nichols, AND B. Brooks. Method optimization for fathead minnow (Pimephales promelas) liver S9 isolation. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.
Nichols, J., B. Du, J. Berninger, K. Connors, K. Chambliss, R. Erickson, A. Hoffman, AND B. Brooks. Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, in fathead minnows. SETAC, Vancouver, BC, CANADA, November 09 - 13, 2014.
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, 44(4):345-351, (2014).
Consoer, D., A. Hoffman, P. Fitzsimmons, Pat Kosian, AND J. Nichols. Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout(Oncorhynchus mykiss). AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 156:65-73, (2014).
2013
Connors, K., B. Du, P. Fitzsimmons, A. Hoffman, C. Chambliss, J. Nichols, AND B. Brooks. Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 32(8):1810-1818, (2013).
Nichols, J., A. Hoffman, T. Ter Laak, AND P. Fitzsimmons. Hepatic clearance of 6 polyaromatic aromatic hydrocarbons by isolated trout livers: Prediction from in vitro clearance by liver S9 fractions. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 136(2):359-372, (2013).
Fitzsimmons, P., A. Hoffman, AND J. Nichols. Incremental improvements to the trout S9 biotransformation assay. Presented at SETAC, Nashville, TN, November 17 - 21, 2013.
Fay, K., R. Mingoia, I. Goeritz, D. Nabb, A. Hoffman, B. Ferrell, H. Peterson, J. Nichols, H. Segner, AND X. Han. Inter-laboratory comparison of clearance rates of xenobiotics by cryopreserved trout hepatocytes for the prediction of bioaccumulation potential. Presented at Society of Toxicology, March 10 - 14, 2013.
Fay, K., R. Mingoia, I. Goeritz, D. Nabb, A. Hoffman, B. Ferrell, H. Peterson, J. Nichols, H. Segner, AND X. Han. Inter-laboratory comparison of xenobiotic clearance rates determined using cryopreserved trout hepatocytes for improving bioaccumulation predictions. Presented at Health and Environmental Sciences Institute, Duluth, MN, November 01, 2013.
Berninger, J., K. Fay, C. LaLone, D. Dreier, E. Durhan, L. Makynen, M. LEE, Dan Villeneuve, G. Ankley, AND J. Nichols. Prioritizing and selecting pharmaceuticals to test the read-across approach: using human clearance rates to predict biotransformation in fish. Presented at SETAC, Nashville, TN, November 17 - 21, 2013.
Nichols, J., D. Huggett, J. Arnot, P. Fitzsimmons, AND C. Cowan-Ellsberry. Towards improved models for predicting bioconcentration of well-metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 32(7):1611-1622, (2013).
Fay, K., C. LaLone, E. Durhan, M. Lee, L. Makynen, Dan Villeneuve, G. Ankley, J. Nichols, AND J. Berninger. Use of human clearance rates to predict the biotransformation of pharmaceuticals by fish: A test of the read-across approach. Presented at SETAC, Nashville, TN, November 17 - 21, 2013.
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Use of isolated hepatocytes to predict measured hepatic clearance of five polyaromatic hydrocarbons by perfused trout livers. Presented at Society of Toxicology, March 10 - 14, 2013.
2012
Nichols, J. In vitro methods for the determination of test chemicals metabolism utilizing fish liver subcellular fractions and hepatocytes. Presented at SETAC Europe.
Nichols, J. In vivo testing of chemicals that undergo substantial biotransformation: An opportunity to advance in vitro-in vivo metabolism extrapolation procedures for fish. Presented at Health and Environmental Sciences/HESI Workshop on In Vivo Bioaccumulation Testing with Fish.
Nichols, J., A. Hoffman, P. Fitzsimmons, K. Fay, AND T. Ter Laak. Predicting the accumulation of well-metabolized chemicals by fish from measured rates of in vitro intrinsic clearance: Progress made and challenges ahead. Presented at Invited oral presentation, Stockholm University.