Science Inventory

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Crofton, K. EPA National Center for Computational Toxicology UPDATE (ICCVAM public forum). ICCVAM Public Forum, Bethesda, MD, May 25, 2016. https://doi.org/10.23645/epacomptox.5071255

Crofton, K., G. Patlewicz, M. Martin, AND R. Judson. EU-ToxRisk Project and NCCT Capabilities (EU-ToxRisk-Tox21 Joint Meeting). EU-ToxRisk-Tox 21 Joint Meeting, Mainz, GERMANY, September 12 - 14, 2016. https://doi.org/10.23645/epacomptox.5071252

Hughes, M., D. Ross, J. Starr, E. Scollon, M. Wolansky, K. Crofton, AND M. DeVito. Environmentally relevant mixing ratios in cumulative assessments: a study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to neurotoxicity in the rat. TOXICOLOGY. Elsevier Science Ltd, New York, NY, , 19-28, (2016).

Baker, N., T. Knudsen, K. Crofton, AND G. Patlewicz. High-throughput literature mining to support read-across predictions of toxicity (ASCCT meeting). Presented at American Society for Cellular and Computational Toxicology, Research Triangle Park, NC, September 29 - 30, 2016. https://doi.org/10.23645/epacomptox.5071423

Simmons, Steve, Eric Watt, K. Paul-Friedman, K. Houck, R. Judson, M. Hornung, AND K. Crofton. Identification of Chemical Features Linked to Thyroperoxidase Inhibition (SOT). Presented at Society of Toxicology Annual Meeting, New Orleans, LA, March 13 - 17, 2016. https://doi.org/10.23645/epacomptox.5155789

Williams, A., M. Linnenbrink, K. Crofton, AND R. Thomas. Investigating Impact Metrics for Performance for the US EPA National Center for Computational Toxicology (ACS Fall meeting). Presented at ACS, Phildelphia, PA, August 21 - 25, 2016. https://doi.org/10.23645/epacomptox.5058502

Richard, A., R. Judson, K. Houck, C. Grulke, P. Volarath, I. Thillainadarajah, C. Yang, J. Rathman, M. Martin, J. Wambaugh, T. Knudsen, K. Mansouri, J. Kancherla, G. Tier, A. Williams, S. Little, K. Crofton, AND R. Thomas. The ToxCast Chemical Landscape - Paving the Road to 21st Century Toxicology. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 29(8):1225-1251, (2016).

Paul-Friedman, K., Eric D. Watt, Michael W. Hornung, Joan M. Hedge, Richard S. Judson, Kevin M. Crofton, Keith A. Houck, AND Steven O. Simmons. Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors within the ToxCast Phase I and II Chemical Libraries. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 151(1):160-180, (2016).

Langley, G., I. Adcock, F. Busquet, K. Crofton, E. Csernok, C. Giese, T. Heinonen, K. Herrmann, M. Hofmann-Apitius, B. Landesmann, L. Marshall 11, E. McIvor, A. Muotri, F. Noor, K. Schutte, T. Seidle, A. van de Stolpe, H. Van Esch, C. Willett, AND G. Woszczek. Towards a 21st century roadmap for biomedical research and drug discovery: Consensus report and recommendations. DRUG DISCOVERY TODAY. Elsevier Science Ltd, New York, NY, , 1-13, (2016).

Shah, I., Woodrow Setzer, J. Jack, K. Houck, R. Judson, T. Knudsen, J. Liu, M. Martin, D. Reif, Ann M. Richard, Russell S. Thomas, K. Crofton, David J. Dix, AND Robert J. Kavlock. Using ToxCast data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(7):910-919, (2016).

Wilson, V., G. LeBlanc, S. Kullman, K. Crofton, P. Schmieder, AND M. Jacobs. Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing. PeerJ. PeerJ Inc., Corte Madera, CA, 4:e2605v1, (2016).

Crofton, K. Adverse Outcome Pathways: Challenges in Use and Development . Presented at Global Chem Meeting, Baltimore, MD, March 03, 2015. https://doi.org/10.23645/epacomptox.5080000

Watt, E., D. F. Kapraun, T. B. Knudsen, K. Crofton, AND R. Judson. Computational Modeling of Thyroid Hormone Regulated Neurodevelopment for Chemical Prioritization (SOT). Presented at SOT Annual Meeting, San Diego, CA, March 22 - 26, 2015.

Crofton, K. Developing Data and Computational Models to Enhance Risk Decisions: An Update on ToxCast and ExpoCast (Dalian University, China). Presented at Dahlian University presentation, Dalian, CHINA, April 22, 2015. https://doi.org/10.23645/epacomptox.5079982

Crofton, K. Developing Data and Computational Models to Enhance Risk Decisions: An Update on ToxCast and ExpoCast (ISCRPM). Presented at 2015 International Symposium on Chemicals Risk Prediction and Management (ISCRPM-2015), Xiamen, CHINA, April 23 - 24, 2015. https://doi.org/10.23645/epacomptox.5080009

Paul Friedman, K., Eric Watt, J. Hedge, K. Crofton, M. Hornung, AND Steve Simmons. Development of a tiered screening strategy for a molecular-initiating event: thyroperoxidase inhibition (SOT). Presented at SOT Annual Meeting, San Diego, CA, March 22 - 26, 2015. https://doi.org/10.23645/epacomptox.5178835

Aoyama, H., N. Takahashi, Y. Shutoh, A. Motomura, AND K. Crofton. Developmental Neurotoxicology: History and Outline of Developmental Neurotoxicity Study Guidelines. Food Safety. Food Safety Commission, Cabinet Office, Government of Japan, TOKYO, Japan, 3(2):48-61, (2015).

Knudsen, T. B., A. M. Richard, P. G. Kothiya, R. S. Judson, K. A. Houck, K. C. Crofton, R. S. Thomas, S. Little, E. S. Hunter, N. C. Baker, C. K. M. Leung, J. Palmer, A. Smith, M. Colwell, P. West, R. Burrier, AND L. Egnash. Evaluation of 1066 ToxCast Chemicals in a human stem cell assay for developmental toxicity (SOT). Presented at Society of Toxicology, San Diego, CA, March 21 - 26, 2015. https://doi.org/10.23645/epacomptox.5178703

Segal, D., S. Makris, A. Kraft, A. Bale, M. Gilbert, D. Bergfelt, K. Raffaele, R. Blain, K. Fedak, M. Selegrade, AND K. Crofton. Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 72(1):94-101, (2015).

Mundy, W., S. Padilla, J. Breier, K. Crofton, M. Gilbert, D. Herr, K. Jensen, N. Radio, K. Raffaele, K. Schumacher, Tim Shafer, AND J. Cowden. Expanding the test set: Chemicals with potential to disrupt mammalian brain development. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, 52:25-35, (2015).

Judson, Richard S., F. Magpantay, V. Chickarmane, C. Haskell, N. Tania, J. Taylor, M. Xia, R. Huang, D. Rotroff, D. Filer, K. Houck, M. Martin, N. Sipes, A. Richard, K. Mansouri, Woodrow Setzer, T. Knudsen, K. Crofton, AND R. Thomas. Integrated Model of Chemical Perturbations of a Biological PathwayUsing 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, :1-42, (2015).

Bal-Price, A., K. Crofton, M. Leist, S. Allen, M. Arand, T. Buetler, N. Delrue, R. FitzGerald, T. Hartung, T. Heinonen, H. Hogberg, S. Hougaard Bennekou, W. Lichtensteiger, D. Oggier, M. Paparella, M. Axelstad, A. Piersma, E. Rached, B. Schilter, G. Schmuck, L. Stoppini, E. Tongiorgi, M. Tiramani, F. Monnet-Tschudi, M. Wilks, T. Ylikomi, AND E. Fritsche. International STakeholder NETwork (ISTNET): Creating a Developmental Neurotoxicity Testing (DNT) Roadmap for Regulatory Purposes. Archives of Toxicology. Springer, New York, NY, 89(2):269-287, (2015).

Crofton, K. New Strategies for Regulatory Developmental Neurotoxicity Testing: Translating HTS Bioassay Results to Risk Estimates (DENAMIC Workshop). DENAMIC Workshop, Amsterdam, NETHERLANDS, December 07 - 08, 2015. https://doi.org/10.23645/epacomptox.5071249

Baghdikian, C., T. Bahadori, R. Thomas, K. Crofton, AND M. Linnenbrink. Stakeholder engagement and feedback efforts to increase use of the iCSS ToxCast Dashboard (SETAC). Presented at Society of Environmental Toxicology and Chemistry, Salt Lake City, UT, November 01 - 05, 2015.

Bouhifd, M., M. Andersen, C. Baghdikian, K. Boekelheide, K. Crofton, A. Fornace Jr., A. Kleensang, H. Li, C. Livi, A. Maertens, P. McMullen, M. Rosenberg, R. Thomas, M. Vantangoli, J. Yager, L. Zhao, AND T. Hartung. The Human Toxome Project. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 32:112-124, (2015).