Science Inventory

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ABBOTT, B. D., C. R. WOOD, A. WATKINS, K. DAS, AND C. LAU. Peroxisome Proliferator-Activated Receptor Alpha (PPARa), Beta (PPARI3), and Gamma (PPARy) Expression in Human Fetal Tissues. Presented at Teratology Society Meeting, Louisville, KY, June 26 - 30, 2010.

ABBOTT, B. D. Teratogenic impact of dioxin-activated AHR in laboratory animals. Chapter 17, Raimo Pohjanvitra, D.V.M, Ph.D. (ed.), The AH Receptor in Biology and Toxicology. John Wiley & Sons, Inc, Hoboken, NJ, , 257-266, (2011).

ABBOTT, B. D. The Etiology of Cleft Palate: a 50 year search for mechanistic and molecular understanding. BIRTH DEFECTS RESEARCH PART B: DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 89(4):266-274, (2010).

ROSEN, M. B., J. E. SCHMID, D. Zehr, K. DAS, H. REN, B. D. ABBOTT, C. LAU, AND C. CORTON. Toxicogenomic profiling of perfluorononanoic acid in wild-type and PPARa-null mice. Presented at Society of Toxicology 2010 Annual Meeting, Salt Lake City, UT, March 07 - 11, 2010.

Lee, J., W. Ward, H. Ren, B. Vallanat, B. D. ABBOTT, AND C. CORTON. Transcriptional profiling of mouse and human livers at different life stages. Presented at Ssociety of Toxicology 49th Annual meeting, Salt Lake City, UT, March 07 - 11, 2010.

Wolf, C., D. Zehr, J. Schmid, C. Lau, AND B. D. ABBOTT. Developmental toxicity and serum levels of perfluorononanoic acid in the wild-type and PPAR-alpha knockout mouse after gestational exposure. Presented at Program for Teratology Society Annual Meeting, Rio Grande, PR, June 27 - July 01, 2009.

WOLF, C. J., C. LAU, AND B. D. ABBOTT. Developmental toxicity of perfluorononanoic acid is dependent on peroxisome proliferator activated receptor-alpha. Presented at 2009 SOT annual meeting, Baltimore, MD, March 15 - 19, 2009.

ABBOTT, B. D., C. J. WOLF, K. DAS, R. ZEHR, J. E. SCHMID, A. B. LINDSTROM, M. J. STRYNAR, AND C. LAU. Devopmental toxicity of perfluorooctane Sulfonate (PFOS) is not dependent on expression on peroxisome proliferator activated receptor-alpha (PPAR-alpha)in the mouse. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 27(3-4):258-265, (2009).

WHITE, S. S., K. KATO, L. T. JIA, B. J. BASDEN, A. M. CALAFAT, E. P. HINES, J. P. STANKO, C. J. WOLF, B. D. ABBOTT, AND S. E. FENTON. Effects of Perfluorooctanoic Acid on Mouse Mammary Gland Development and Differentiation Resulting from Cross-Foster and Restricted Gestational Exposures. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 27(3-4):289-298, (2009).

ROSEN, M. B., C. J. CORTON, J. E. SCHMID, R. ZEHR, K. DAS, H. REN, B. D. ABBOTT, AND C. LAU. GENE PROFILING IN WILD-TYPE AND PPARα-NULL MICE EXPOSED TO PERFLUOROOCTANE SULFONATE . Presented at 2009 SOT Annual Meeting, Baltimore, MD, March 15 - 19, 2009.

ABBOTT, B. D., C. J. WOLF, K. DAS, AND C. LAU. Genetically altered mice for evaluation of mode-of-action (MOA). Presented at HESI DART New Direction Workshop, Washington, DC, April 29 - 30, 2009.

CORTON, C., S. D. HESTER, L. ALEKSUNES, H. REN, B. VALLANAT, M. H. GEORGE, M. B. ROSEN, B. D. ABBOTT, C. KLAASSEN, S. NESNOW, AND C. LAU. Improving Mode of Action Analysis Using Transcript Profiling in Nullizygous Mouse Models. Presented at Symposium on Toxicity Pathways-Based Risk Assessment:Preparing for Paradigm Change, Washington, DC, May 11 - 13, 2009.

ABBOTT, B. D., K. DAS, C. R. WOOD, AND C. LAU. PPARα, PPARβ, and PPARγ expression in prenatal and postnatal mouse tissues and an evaluation of the effects of perfluorooctanoic acid (PFOA) on peroxisome proliferator-activated receptor (PPAR) expression. Presented at 2009 Teratology Meeting, Rio Grande, PUERTO RICO, June 26 - July 03, 2009.

ABBOTT, B. D. Review of the expression of Peroxisome Proliferator Activated Receptors alpha (PPARα), beta (PPAR β), and gamma (PPAR() in rodent and human development. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 27(3-4):246-257, (2009).

Wolf, D. C., T. Moore, B. D. Abbott, M. B. Rosen, K. Das, R. D. Zehr, A. B. Lindstrom, M. J. Strynar, AND C. S. Lau. Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPARa-knocked out and wild-type mice. TOXICOLOGICAL PATHOLOGY 36(4):632-639, (2008).

U.S. EPA, M. B. ROSEN, D. C. WOLF, B. D. ABBOTT, C. CORTON, J. E. SCHMID, C. R. WOOD, K. DAS, C. LAU, AND R. ZEHR. DEVELOPMENTAL TOXICOGENOMIC STUDIES OF PFOA AND PFOS IN MICE. . Presented at PFAA Days II, RTP, NC, June 03 - 04, 2008.

U.S. EPA, AND B. D. ABBOTT. Mechanisms of perfluoroalkyl acid (PFAA) toxicity: Involvement of peroxisome proliferator activator receptor alpha (PPAR) molecular signals. Presented at PFAA Days II, RTP, NC, June 03 - 04, 2008.

ROSEN, M. B., J. S. LEE, H. REN, B. VALLANAT, J. Liu, M. P. Waalkes, B. D. ABBOTT, C. S. LAU, AND C. CORTON. Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 103(1):46-56, (2008).

WOLF, C. J., M. TAKACS, AND B. D. ABBOTT. ACTIVATION ASSAY FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR- ALPHA (PPARÁ) BY PERFLUOROALKYL ACIDS (PFAAS) IN COS-1 CELLS. Presented at Current Concepts in Toxicology Workshop, Arlington, VA, February 14 - 16, 2007.

TAKACS, M. L. AND B. D. ABBOTT. Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (Ppar Alpha, Gamma, Beta Delta) by Perfluorooctanoic Acid (Pfoa) and Perfluorooctane Sulfonate (PFOS). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 95(1):108-117, (2007).

WOLF, D. C., B. D. ABBOTT, AND C. S. LAU. COMPARATIVE HEPATIC EFFECTS OF PERFLUOROOCTANOIC ACID AND WY 14,643 IN PPARÁ KNOCKED OUT AND WILD-TYPE MICE. Presented at Current Concepts in Toxicology-Perfluorinalkyl Acids and Related Chemistries: Toxicokinetics and Mode-of-Action Workshop, Arlington, VA, February 14 - 16, 2007.

WOLF, C. J., S. E. FENTON, J. E. SCHMID, A. M. CALAFAT, Z. KUKLENYIK, J. R. THIBODEAUX, K. DAS, S. S. WHITE, C. S. LAU, AND B. D. ABBOTT. Developmental Toxicity of Perfluorooctanoic Acid (Pfoa) After Cross Foster and Restricted Gestational Exposures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 95(2):462-473, (2007).

ROSEN, M. B., B. D. ABBOTT, J. E. SCHMID, DAN ZEHR, K. DAS, C. J. WOLF, AND C. S. LAU. GENE PROFILING IN WILD TYPE AND PPARÁ NULL MICE EXPOSED TO PFOA. Presented at Current Concepts in Toxicology Workshop, Arlington, VA, February 14 - 16, 2007.

LLOYD, S., B. VALLANAT, M. B. ROSEN, B. D. ABBOTT, K. DAS, R. ZEHR, C. S. LAU, AND C. CORTON. IDENTIFICATION OF COMMON GENES AND PATHWAYS REGULATED BY PPARÁ ACTIVATORS. Presented at Society of Toxicology Annual Meeting 2007, Charlotte, NC, March 25 - 29, 2007.

CORTON, C., M. B. ROSEN, H. REN, B. VALLANAT, B. D. ABBOTT, AND C. S. LAU. IDENTIFICATION OF GENES AND PATHWAYS REGULATED BY PPARα ACTIVATORS: DIFFERENCES BETWEEN WY-14,643 AND PFOA. Presented at EUROTOX 2007, Amsterdam, NETHERLANDS, October 07 - 10, 2007.