Science Inventory

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KENYON, E. M., T. L. LEAVENS, AND R. A. PEGRAM. Development of a Multiroute Human PBPK Model for Bromodichloromethane (BDCM). Presented at 2009 Annual Society of Toxicology meeting, Baltimore, MD, March 15 - 19, 2009.

CORTON, C., H. A. EL-MASRI, R. A. PEGRAM, E. L. CROOM, J. E. SIMMONS, M. F. HUGHES, S. SIMMONS, J. JACK, J. F. WAMBAUGH, AND I. A. SHAH. Experimental Models for Quantitative Analysis of Hepatocrcinogenesis. Presented at Computational Toxicology Board of Scientific Counselors Review, RTP, NC, September 29 - 30, 2009.

EL-MASRI, H. A., J. E. SIMMONS, R. A. PEGRAM, R. A. HARRISON, S. YAVANHXAY, S. M. DOWD, AND M. V. EVANS. DEVELOPMENT OF A PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL FOR THE INHALATION OF 2,2,4-TRIMETHYLPENTANE (TMP) IN LONG EVANS RATS. Presented at Society of Toxicology Annual Meeting, Seattle, WA, March 16 - 20, 2008.

SIMMONS, J. E., S. D. RICHARDSON, G. E. RICE, T. F. SPETH, R. J. MILTNER, E. S. HUNTER, M. G. NAROTSKY, K. M. SCHENCK, L. D. CLAXTON, R. A. PEGRAM, T. A. MCDONALD, D. S. BEST, S. H. WARREN, A. B. DEANGELO, W. O. WARD, J. G. PRESSMAN, AND L. K. TEUSCHLER. The Power of Four (the 4-Lab Study): ORD’s Integrated Disinfection By-Products Mixtures Research Project. Presented at Office of Solid Waste Science Seminar, Washington, DC, September 09 - 12, 2008.

BIELMEIER, S. R., A. E. MURR, D. S. BEST, R. A. HARRISON, R. A. PEGRAM, J. M. GOLDMAN, AND M. G. NAROTSKY. EFFECTS OF BROMODICHLOROMETHANE ON EX VIVO AND IN VITRO LUTEAL FUNCTION AND BROMODICHLOROMETHANE TISSUE DOSIMETRY IN THE PREGNANT F344 RAT. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 21(5):919-928, (2007).

Geter, D. R., L W. Chang, N. M. Hanley, M. K. Ross, R A. Pegram, AND A B. DeAngelo. ANALYSIS OF IN VIVO AND IN VITRO DNA STRAND BREAKS FROM TRIHALOMETHANE EXPOSURE. JOURNAL OF CARCINOGENESIS 3:2, (2004).

Ross, M. K. AND R A. Pegram. BIOTRANSFORMATION AND GENOTOXICITY OF THE DRINKING WATER DISINFECTION BYPRODUCT BROMODICHLOROMETHANE: DNA BINDING MEDIATED BY GLUTATHIONE TRANSFERASE THETA 1-1. TOXICOLOGICAL AND APPLIED PHARMICOLOGY. Elsevier Science BV, Amsterdam, Netherlands, 195(2):166-81, (2004).

Chen, J., T. L. Thirkill, P. N. Lohstroh, S. R. Bielmeier, M G. Narotsky, D S. Best, R A. Harrison, K. Natarajan, R A. Pegram, B. L. Lasley, AND G. C. Douglas. BROMODICHLOROMETHANE INHIBITS HUMAN PLACENTAL TROPHOBLAST DIFFERENTIATION. TOXICOLOGICAL SCIENCES 78(1):166-174, (2004).

Ross, M. K., C R. Eklund, AND R A. Pegram. COMPARISON OF DETOXIFICATION AND BIOACTIVATION PATHWAYS FOR BROMODICHLOROMETHANE IN THE RAT. Presented at Society of Toxicology, Baltimore, MD, March 21-25, 2004.

Pegram, R A., M. K. Ross, A B. DeAngelo, J W. Allis, AND G. Zhao. BROMODICHLOROMETHANE TOXICOKINETICS: LINKING METABOLISM TO EFFECT. Presented at Society of Toxicology 42nd Annual Meeting, Salt Lake City, Utah, March 9-13, 2003.

Chen, J., G. C. Douglas, T. L. Thirkill, P. N. Lohstroh, S. R. Bielmeier, M G. Narotsky, D S. Best, R. A. Harrison, R A. Harrison, K. Natarajan, R A. Pegram, AND B. L. Lasley. EFFECT OF BROMODICHLOROMETHANE ON CHORIONIC GONADOTROPHIN SECRETION BY HUMAN PLACENTAL TROPHOBLAST CULTURES. TOXICOLOGICAL SCIENCES 76(1):75-82, (2003).

Chen, J., T. L. Thirkill, P. N. Lohstroh, S. R. Bielmeier, M G. Narotsky, D S. Best, R. A. Harrison, K. Natarajan, R A. Pegram, G. C. Douglas, AND B. L. Lasley. EFFECT OF BROMODICHLOROMETHANE ON HUMAN TROPHOBLAST CHORIONIC GONADOTROPHIN SECRETION. Presented at Endocrine Society, Philadelphia, PA, June 19-22, 2003.

Ross, M. K. AND R A. Pegram. GLUTATHIONE S-TRANSFERASE THETA 1-1-DEPENDENT METABOLISM OF THE DISINFECTION BYPRODUCT BROMODICHLOROMETHANE. CHEMICAL RESEARCH IN TOXICOLOGY 16:216-226, (2002).

Landi, S, A. Naccarati, M. K. Ross, N. M. Hanley, L. A. Dailey, R. B. Devlin, M. Vasquez, R A. Pegram, AND D M. DeMarini. INDUCTION OF DNA STRAND BREAKS BY TRIHALOMETHANES IN PRIMARY HUMAN LUNG EPITHELIAL CELLS. MUTATION RESEARCH 538(1-2):41-50, (2003).

Ross, M. K. AND R A. Pegram. [35S]-LABELING OF THE SALMONELLA TYPHIMURIUM GLUTATHIONE POOL TO ASSESS GLUTATHIONE-MEDIATED DNA BINDING BY 1,2-DIBROMOETHANE. CHEMICO-BIOLOGICAL INTERACTIONS. Elsevier Ireland Limited, Limerick, Ireland, 146(1):39-49, (2003).

Arbuckle, T. E., S. E. Hrudey, S. W. Krasner, J. R. Nuckols, S D. Richardson, P. C. Singer, P Mendola, L. Dodds, C. E. Weisel, D. L. Ashley, K. L. Froese, R A. Pegram, I. R. Schultz, J. Reif, A. M. Bachand, F. M. Benoit, M. C. Lynberg, C. Poole, AND K. Waller. ASSESSING EXPOSURE IN EPIDEMIOLOGIC STUDIES TO DISINFECTION BY-PRODUCTS IN DRINKING WATER: REPORT FROM AN INTERNATIONAL WORKSHOP. ENVIRONMENTAL HEALTH PERSPECTIVES 110(1):53-60, (2002).

Ross, M. K. AND R A. Pegram. COMPARISON OF RATES OF GLUTATHIONE (GSH) - CONJUGATION OF TRIHALOMETHANES. Presented at Society of Toxicology, Nashville, TN, March 17-21, 2002.

Leavens, T L., M W. Case, R A. Pegram, R A. Pegram, D M. DeMarini, M. C. Madden, J. L. Valentine, AND B. C. Blount. DISPOSITION OF BROMODICHLOROMETHANE IN HUMANS FOLLOWING ORAL AND DERMAL EXPOSURE. Presented at Society of Toxiocology Annual Meeting, Nashville, TN, March 17-21, 2002.

Allis, J W., B. P. Anderson, G. Zhao, T. M. Ross, AND R A. Pegram. EVIDENCE FOR THE INVOLVEMENT OF CYP1A2 IN THE METALBOLISM OF BROMODICHLOROMETHANE IN RAT LIVER. TOXICOLOGY 176(2002):25-37, (2002).

Hughes, T. J., L K. Teuschler, G Rice, J E. Simmons, E S. Hunter, L D. Claxton, M G. Narotsky, R A. Pegram, S. D. Richardson, AND T F. Speth. OFFICE OF RESEARCH AND DEVELOPMENT'S FOUR LAB STUDY: TOXICOLOGICCAL AND CHEMICAL EVALUATION OF COMPLEX MIXTURES OF DISINFECTION BY-PRODUCTS (DBPS) AND QUALITY ASSURANCE ACTIVITIES FOR A LARGE U. S. EPA MULTILABORATORY STUDY. Presented at QA Managers' Meeting, Duluth, MN, October 15-18, 2002.

Pegram, R A. AND M. K. Ross. DNA BINDING POTENTIAL OF BROMODICHLOROMETHANE MEDIATED BY GLUTATHIONE S-TRANSFERASE THETA 1-1. Presented at SOT, San Francisco, CA, March 25-29,2001.

Ross, T. M., B. P. Anderson, R A. Pegram, J W. Allis, AND G. Zhao. EVIDENCE FOR BROMODICHLOROMETHANE METABOLISM BY CYTOCHROME P-450 1A2. Presented at SOT, San Francisco, CA, March 25-29,2001.

Ross, M. K. AND R A. Pegram. GLUTATHIONE S-TRANSFERASE-MEDIATED METABOLISM OF BROMODICHLOROMETHANE. Presented at SOT, San Francisco, CA, March 25-29, 2001.

Allis, J W., B. L. Brown, G. Zhao, AND R A. Pegram. THE EFFECTS OF INHALATION EXPOSURE TO BROMODICHLOROMETHANE ON SPECIFIC RAT CYP ISOENZYMES. TOXICOLOGY. Elsevier Ireland Limited, Limerick, Ireland, 161:67-77, (2001).

Valentine, J. L., R A. Pegram, J D. Prah, M W. Case, D. L. Ashley, M V. Evans, AND V A. Benignus. PHARMACOKINETIC MODELING OF DERMAL EXPOSURE TO BROMODICHLOROMETHANE (BDCM) IN HUMAN VOLUNTEERS. Presented at Society of Toxicology Annual Meeting, Philadelphia, Pennsylvania, March 19-23, 2000.