Office of Research and Development Publications

<< Previous

Next >>

Disinfection of water decreases waterborne disease. Disinfection byproducts (DBPs) are formed by the reaction of oxidizing disinfectants with inorganic and organic materials in the source water. The U.S. EPA regulates five haloacetic acid (HAA) DBPs as a mixture. The objective ...

DOSE ADDITIVITY OF ATRAZINE AND BROMODICHLOROMETHANE IN CAUSING<br>PREGNANCY LOSS IN F344 RATS.<br><br>AUTHORS (ALL): Narotsky, Michael G1; Best, Deborah S1; Bielmeier, Susan R2; Cooper, Ralph L1<br>SPONSOR NAME: James E Andrews<br><br>INSTITUTIONS (ALL): <br>1. Reproductive Toxi...

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is often called the most toxic man-made compound. However, it is but the prototype for a family of structurally related compounds which have a common mechanism of action, induce a common spectrum of biological responses, and are...

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field.

Traditional data sources for cancer risk assessment are resource-intensive, retrospective, and not feasible for the vast majority of environmental chemicals. Incorporation of quantitative genomic data from short-term rodent studies may adequately define protective thresholds for ...

Early-life environmental exposures to developmental neurotoxicants carries a risk for children&rsquo;s health. Studies have shown associations between neurotoxicant exposure and increased risk of neurodevelopmental disorders (NDD), such as autism spectrum and attention-deficit di...

The US Environmental Protection Agency&rsquo;s ToxCast program has generated toxicity data for thousands of chemicals. However, it is recognized that the current panel of assays does not adequately assess the potential for chemical neurotoxicity. Networks of neurons grown on micr...

The potential for environmental chemicals to produce birth defects is largely unknown. Mouse embryonic stem cells were used to profile the bioactivity of chemicals on the EPA Contaminant Candidate List 4 (CCL4). Differentiation and cytotoxicity were evaluated for 81 non-volatile ...

Black carbon (BC) is ubiquitous in pelagic sediments and presumed to have an older radiocarbon age due to long ocean residence times and pre-aging in terrestrial soils. Here, we analyzed sediments from five regions in the subtropical Atlantic Ocean to quantify the black carbon fr...

Statistically assessing ecological models is inherently difficult because data are autocorrelated and this autocorrelation varies in an unknown fashion. At a simple level, the linking of a single species to a habitat type is a straightforward analysis. With some investigation int...

As part of a demonstration project focusing on the Common Loon (Gavia immer), the U.S. Environmental Protection Agency's National Health and Environmental Effects Research Laboratory is using a matrix population modeling framework to integrate demographic information for extrapol...

EPA H2O is an open source Geographic Information System (GIS) based demonstration tool, used for assessing Ecosystem Services (ES) at local to regional scales. EPA H2O was developed as a preliminary assessment tool in support of research being conducted in the Tampa Bay, FL USA w...

Hepatic carboxylesterases (Ces) catalyze the metabolism of drugs, environmental toxicants, and endogenous lipids and are known to be regulated by multiple nuclear receptors. Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical that has been associated with dyslipidemia in ...

Arsenic is a known human carcinogen. Early-life exposure to inorganic arsenic induces tumors in humans and in C3H mice. We hypothesized that arsenic exposure&nbsp;in utero&nbsp;may induce epigenetic changes at the level of DNA methylation and miRNA alterations that could lead to ...

The use of zebrafish in both human and ecological toxicity assessments is becoming more accepted as toxicologists begin the recognize what biologists have noted for the last decade: that there are many parallels between zebrafish and other vertebrate organisms, such that zebrafis...

To explore a number of questions in the area of risk communications, the Interagency Task Force on Environmental Cancer and Heart and Lung Disease, held a Workshop on Evaluation and Effective Risk Communication which brought together experts from academia, government agencies, an...

This Facilitator Manual provides the practical steps necessary for an agency or organization to implement a multi-session, participatory workshop for municipalities to engage their communities in the development of stormwater funding solutions. The Manual is a paired resource wit...

Microbiota regulate important physiologic processes during early host development. They also biotransform xenobiotics and serve as key intermediaries for chemical exposure. Antimicrobial agents in the environment may disrupt these complex interactions and alter key metabolic func...

Adverse intrauterine environments have been associated with increased risk of later cardiovascular disease and hypertension. In an animal model using diverse developmental toxicants, we measured blood pressure (BP), renal nephron endowment, renal glucocorticoid receptor (GR) gene...

Perfluorononanoic acid (PFNA) is a ubiquitous and persistent environmental contaminant. Although its levels in the environment and in humans are lower than those of perfluorooctane sulfonate(PFOS) or perfluorooctanoic acid (PFOA), a steady trend of increases in the general popula...

Oil spill chemical response agents, including those that function as dispersants, solidifiers, surface washers, and surface collectors, are used globally to combat oil spills by changing the physical structure of the oil in the spill to facilitate breakdown and biodegradation. A ...

The National Lakes Assessment 2017: A Collaborative Survey of Lakes in the United States presents the results of a second evaluation of the lakes in the United States. This report is part of the National Aquatic Resource Surveys, a series of statistically based surveys designed t...

Wildland fire smoke contains hazardous levels of fine particulate matter (PM2.5), a pollutant shown to adversely effect health. Estimating fire attributable PM2.5 concentrations is key to quantifying the impact on air quality and subsequent health burden. This is a challenging pr...

Federal estuary management programs have widely used ecosystem services concepts to frame management issues and communicate with stakeholders. However, widespread implementation of ecosystem services assessments in estuary management has been limited due to concerns of being too ...

Coastal towns and cities are looking for more sustainable ways to build on local assets to maintain or improve their quality of life. Access to more locally relevant information is needed to better assist communities in making progress toward their goals, especially in smaller co...