Office of Research and Development Publications

<< Previous

Next >>

Chemical-induced liver cancer occurs in rodents through well-characterized adverse outcome pathways. We hypothesized that measurement of the 6 most common molecular initiating events (MIEs) in liver cancer adverse outcome pathways in short-term assays using only gene expression w...

Rural Ghanaian communities continue using microbiologically contaminated surface water sources due in part to undesirable organoleptic characteristics of groundwater from boreholes. Our objective was to identify thresholds of physical and chemical parameters associated with consu...

This document was created to highlight the many ways that the U.S. EPA EnviroAtlas suite of ecosystem services tools can be used to aid in the Health Impact Assessment (HIA) process. Ecosystems provide numerous services and benefits to individuals, communities, businesses, and ot...

Air pollutants have a negative impact on plant growth, primarily through interfering with resource accumulation. Once leaves are in close contact with the atmosphere, many air pollutants, such as O3 and NOx, affect the metabolic function of the leaves and interfere with net carbo...

Background: Toxoplasma gondii infection can be acquired through ingestion of infectious tissue cysts in undercooked meat or environmental oocysts excreted by cats. This cross-sectional study assessed environmental risk factors for T.gondii infections and an association between la...

Although endocrine disrupting compounds have been detected in wastewater and surface waters worldwide using a variety of in vitro effects-based screening tools, e.g. bioassays, few have examined potential attenuation of environmental contaminants by both natural (sorption, degrad...

Using a Climate Resilience Screening Index (CRSI) that was developed to represent resilience to acute weather events at multiple scales for the United States, regions of the United States are compared for resilience. The comparison examined the domains and indicators of CRSI add...

The assessment of environmental exposures for human health is an advancing field, characterized by multiple new methodologic and analytic approaches. The difficulties in examining the many broad-based factors impacting human health outcomes are increasingly recognized, with expos...

This document defines and classifies 338 Final Ecosystem Goods and Services (FEGS), each defined and uniquely numbered by a combination of environmental class or sub-class and a beneficiary category or sub-category. The introductory section provides the rationale and conceptual ...

Traditional methods for cancer risk assessment are resource-intensive, retrospective, and not feasible for the vast majority of environmental chemicals. In this study, we investigated whether quantitative genomic data from short-term studies may be used to set protective threshol...

Environmental exposure to metals is known to cause a number of human toxicities including cancer. Metal-responsive transcription factor 1 (MTF-1) is an important component of metal regulation systems in mammalian cells. Here, we describe a novel method to identify conditions that...

The Deepwater Horizon (DWH) spill was the largest oil spill in US history, requiring an assessment of injuries to nearshore habitats and estuarine organisms. Developing a model of appropriate complexity is critical in an environmental assessment; models should be complex enough t...

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor critical for protecting cells from chemically-induced oxidative stress. We developed computational procedures to identify chemical modulators of Nrf2 in a large database of human microarray data. A gene ...

The circadian rhythms regulate physiological functions and metabolism. Circadian Time (CT) is a unit to quantify the time defined by each organism&rsquo;s endogenous circadian clock, independent of light influence. To understand the gene expression changes throughout CT, C57BL/6J...

A better estimate of overall environmental quality is needed to improve our understanding of the relationship between environmental conditions and human health. Described in this report is the effort to construct an environmental quality index (EQI) representing multiple domains ...

A better estimate of overall environmental quality is needed to improve our understanding of the relationship between environmental conditions and human health. Described in this report is the effort to construct an environmental quality index (EQI) representing multiple domains ...

Childhood mental disorders affect between 13%-20% of children in the United States (US) annually and impact the child, family, and community. Literature suggests associations exist between environmental and children’s mental health such as air pollution with autism and ADHD and s...

Background and Objectives: The interaction between environmental insults and human health is a complex process. Environmental exposures tend to cluster and disamenities such as landfills or industrial plants are often located in neighborhoods with high a percentage of minority a...

The interaction between environmental conditions and human health transpire from complex processes. Environmental exposures tend to cluster and disamenities such as landfills or industrial plants are often located in areas with high a percentage of minority and poor residents. Wh...

The National Rivers and Streams Assessment 2013-2014: A Collaborative Survey (NRSA) presents the results of an unprecedented assessment of the nation’s rivers and streams. This report is part of the National Aquatic Resource Surveys, a series of statistically based surveys design...

Great Lakes connecting channels (GLCC) have not been included in United States regional-scale surveys. We conducted a probabilistic water quality assessment of two GLCC, the St. Marys River, and the Lake Huron-Lake Erie Corridor (HEC) in 2014-2015. We compare the channels to each...

A host of organic fluorochemicals increasingly are being used as surfactant coatings for fabrics and paper products, fire-fighting foams, electronic etching baths and insecticides. Concern for the potential toxicological risk of these types of chemicals had been minimal until re...

This study evaluates the potential for perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) to activate peroxisome proliferator-activated receptors (PPARs), using a transient transfection cell assay. Cos-1 cells were cultured in DMEM with fetal bovine serum (FBS) in ...

Perfluorooctanoic acid (PFOA) is a compound which persists and is found ubiquitously in the environment, wildlife and humans. PFOA affects growth, development and viability of offspring of mice exposed during pregnancy. This study segregates the contributions of gestational and...

Polyfluoroalkyl substances (PFAS) are organic chemicals with wide industrial and consumer uses. They are found ubiquitously at low levels in the environment and detectable in humans and wildlife. Perfluorobutane Sulfonate (PFBS) is a short-chained PFAS used to replace perfluorooc...