Office of Research and Development Publications

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Browne, P., R. Judson, W. Casey, N. Kleinstreuer, AND R. Thomas. SCREENING CHEMICALS FOR ESTROGEN RECEPTOR BIOACTIVITY USING A COMPUTATIONAL MODEL. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 49(14):8804-8814, (2015).

Wambaugh, J., B. Wetmore, R. Pearce, C. Strope, R. Goldsmith, J. Sluka, A. Sedykh, A. Tropsha, S. Bosgra, I. Shah, R. Judson, R. Thomas, AND Woodrow Setzer. Toxicokinetic Triage for Environmental Chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 147(1):55-67, (2015).

Tollefsena, K., S. Scholz, M. Cronin, S. Edwards, J. de Knecht, K. Crofton, N. Garcia-Reyero, T. Hartung, A. Worth, AND C. Patlewicz. Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA workshop report). REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 70(3):629-640, (2014).

Paul, K., J. Hedge, D. Rotroff, M. Hornung, K. Crofton, AND Steve Simmons. Development of a thyroperoxidase inhibition assay for high-throughput screening. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 27(3):387-99, (2014).

Judson, R., K. Houck, M. Martin, T. Knudsen, R. Thomas, N. Sipes, I. Shah, J. Wambaugh, AND K. Crofton. In Vitro and Modeling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Program. BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. Blackwell Publishing, Malden, MA, 115(1):69-76, (2014).

Wetmore, B., B. Allen, H. Clewell III, T. Parker, John F. Wambaugh, L. Almond, M. Sochaski, AND Russell S. Thomas. Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 142(1):210-224, (2014).

Kleensang, A., A. Maertens, M. Rosenberg, S. Fitzpatrick, J. Lamb, S. Auerbach, R. Brennan, K. Crofton, B. Gordon, A. Fornance, K. Gaido, D. Gerhold, R. Haw, A. Henney, A. Ma’ayan, M. McBride, S. Monti, M. Ochs, A. Pandey, R. Sharan, R. Stierum, S. Tugendreich, C. Willett, C. Wittwehr, J. Xia, G. Patton, K. Arvidson, M. Bouhifd, H. Hogberg, T. Luechtefeld, L. Smirnova, L. Zhao, Y. Adeleye, M. Kanehisa, P. Carmichael, M. Andersen, AND T. Hartung. Pathways of Toxicity. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 31(1):53-61, (2014).

Kleinstreuer, N., J. Yang, E. Berg, T. Knudsen, A. Richard, M. Martin, D. Reif, R. Judson, M. Polokoff, D. Dix, R. Kavlock, AND K. Houck. Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms. Nature Biotechnology. Elsevier Science, New York, NY, 32(6):583-591, (2014).

Rotroff, D., M. Martin, D. Dix, D. Filer, K. Houck, T. Knudsen, N. Sipes, D. Reif, M. Xia, R. Huang, AND R. Judson. Predictive Endocrine Testing in the 21st Century Using In Vitro Assays of Estrogen Receptor Signaling Responses. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 48:8706-8716, (2014).

Filer, D., H. Patisaul, T. Schug, D. Reif, AND K. Thayer. Test driving ToxCast: endocrine profiling for1858 chemicals included in phase II. Current Opinion in Pharmacology. Elsevier B.V., Amsterdam, Netherlands, 19(12):145-152, (2014).

KLEINSTREUER, N., D. J. DIX, M. ROUNTREE, N. BAKER, N. SIPES, D. REIF, R. SPENCER, AND T. B. KNUDSEN. A Computational Model Predicting Disruption of Blood Vessel Development. Shayn M.Pierce (ed.), PLOS Computational Biology. Public Library of Science, San Francisco, CA, 9(4):1-20, (2013).

Nel, A., E. Nasser, H. Godwin, D. Avery, T. Bahadori, L. Bergeson, E. Beryt, J. Bonner, D. Boverhof, J. Carter, V. Castranova, J. DeShazo, S. Hussain, A. Kane, F. Klaessig, E. Kuempel, M. Lafranconi, R. Landsiede, T. Malloy, M. Miller, J. Morris, K. Moss, G. Oberdorster, K. Pinkerton, R. Pleus, J. Shatkin, R. Thomas, T. Tolaymat, A. Wang, AND J. Wong. A Multi-Stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment (workshop report). ACS Nano. American Chemical Society, Washington, DC, 7(8):6422–6433, (2013).

Zang, Q., D. Rotroff, AND R. Judson. Binary Classification of a Large Collection of Environmental Chemicals from Estrogen Receptor Assays by Quantitative Structure-Activity Relationship and Machine Learning Methods. Journal of Chemical Information and Modeling. American Chemical Society, Washington, DC, 53:3244−3261, (2013).

WAMBAUGH, J. F., WOODROW SETZER, A. M. Pitruzzello, J. Liu, D. M. Reif, N. C. Kleinstreuer, N. Y. WANG, N. SIPES, M. T. MARTIN, K. DAS, J. C. DeWitt, M. STRYNAR, R. JUDSON, K. A. HOUCK, AND C. LAU. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 136(2):308-327, (2013).

WAMBAUGH, J. F., R. W. SETZER, D. REIF, S. GANGWAL, J. MITCHELLBLACKWOOD, J. A. ARNOT, O. JOLIET, A. FRAME, J. R. RABINOWITZ, T. B. KNUDSEN, R. S. JUDSON, P. P. EGEGHY, D. A. VALLERO, AND E. A. COHEN HUBAL. High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project . Jerald Schnoor (ed.), ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 47(15):8479-8488, (2013).

DUCHARME, N. A., L. E. PETERSON, E. BENFENATI, D. REIF, C. W. McCOLLUM, J. GUSTAFSSON, AND M. BONDESSON. Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies. Thomas B. Knudsen (ed.), REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 41:98-108, (2013).

JUDSON, R., R. J. KAVLOCK, M. T. MARTIN, D. REIF, K. A. HOUCK, T. B. KNUDSEN, A. M. RICHARD, R. R. TICE, M. WHELAN, M. XIA, R. HUANG, C. P. AUSTIN, G. P. DASTON, T. HARTUNG, J. R. FOWLE III, W. WOOGE, W. TONG, AND D. J. DIX. Perspectives on Validation of High-Throughput Assays Supporting 21st Century Toxicity Testing. Sonja von Aulock (ed.), ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 30(1/13):51-66, (2013).

Sipes, N., M. Martin, P. Kothiya, D. Reif, R. Judson, A. Richard, K. Houck, D. Dix, R. Kavlock, AND T. Knudsen. Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 26:878−895, (2013).

ROTROFF, D., D. J. DIX, K. A. HOUCK, R. J. KAVLOCK, T. B. KNUDSEN, M. T. MARTIN, D. REIF, A. M. RICHARD, N. SIPES, Y. A. ABASSI, C. JIN, M. STAMPFL, AND R. JUDSON. Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T‑47D Human Ductal Carcinoma Cells . CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 26(7):1097-1107, (2013).

WETMORE, B. A., J. F. WAMBAUGH, S. S. FERGUSON, L. LI, H. J. CLEWEL III, R. JUDSON, K. FREEMAN, W. BAO, M. A. SOCHASKI, T. CHU, M. B. BLACK, E. HEALY, B. ALLEN, M. E. ANDERSEN, R. D. WOLFINGER, AND R. S. THOMAS. Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays . TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 132(2):327-346, (2013).

JUDSON, R. S., M. T. MARTIN, P. P. EGEGHY, S. GANGWAL, D. M. REIF, P. KOTHIYA, M. A. WOLF, T. CATHEY, T. R. TRANSUE, D. SMITH, J. VAIL, A. FRAME, S. MOSHER, E. A. COHEN-HUBAL, AND A. M. RICHARD. Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System. International Journal of Molecular Sciences. MDPI, Basel, Switzerland, 13(2):1805-1831, (2012).

CROFTON, K. M., W. R. MUNDY, AND T. J. SHAFER. Developmental Neurotoxicity Testing: A Path Forward . Yuji Nakajima (ed.), Congenital Anomalies. Wiley-Blackwell, Hoboken, NJ, 52(3):140-146, (2012).

MARTIN, M. T., T. B. KNUDSEN, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program . Stephen A. Krawetz (Editor-in-Chief) (ed.), Systems Biology in Reproductive Medicine. Informa Healthcare USA, New York, NY, 58(1):3-9, (2012).

KLEINSTREUER, N., D. J. DIX, K. A. HOUCK, R. J. KAVLOCK, T. B. KNUDSEN, M. T. MARTIN, K. B. PAUL, D. REIF, K. M. CROFTON, K. HAMILTON, R. HUNTER, I. A. SHAH, AND R. JUDSON. In vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, Epub(Advance Access):1-44, (2012).

DIX, D. J., K. A. HOUCK, R. JUDSON, N. KLEINSTREUER, T. B. KNUDSEN, M. T. MARTIN, D. REIF, A. M. RICHARD, I. A. SHAH, N. SIPES, AND R. J. KAVLOCK. Incorporating Biological, Chemical and Toxicological Knowledge into Predictive Models of Toxicity: Letter to the Editor. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 130(2):440-441, (2012).