Office of Research and Development Publications

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Water temperature is a key driver of ecological processes in aquatic environments and can influence biological connectivity among riverine habitats. Riverine fish and other mobile aquatic species often must navigate a variety of physical barriers such as dams and culverts. For Pa...

Salmon populations require river networks that provide water temperature regimes sufficient to support a diversity of salmonid life histories across space and time. The importance of cold water refuges for migrating adult salmon and steelhead may seem intuitive, and refuges are c...

Presentation on examining the impacts of an actual regulatory action (NOx SIP Call) on human health. We examined respiratory-related hospital admissions before and after the implementation of the NOx SIP Call. In addition, we found that enriched exposure information (incorporat...

Background: Burning of solid-fuels in rudimentary stoves generates harmful emissions that contribute to poor indoor air quality and have detrimental impacts on human health. Acute health effects include respiratory and eye irritation, cough, acute lower respiratory infection and ...

Exposure concerns from an increasing number of pollutants in US waters requires the need for better monitoring. The pollutants are diverse and can include pesticides, heavy metals, personal care products, natural toxins such as cyanobacterial toxins, and a host of other organic ...

The ability of an organism to metabolize a pollutant is critical to understanding the risk the chemical poses to the organism. In the environment, fish are uniquely exposed to pollutants found in agricultural runoff and discharges from industry and wastewater treatment plants. M...

The National Rivers and Streams Assessment (NRSA) is a national-scale probabilistic survey. As part of the survey design, each site is associated with a weight reflecting the number of stream kilometers in the target population represented by that site. During each round of the s...

Rationale: We have shown that acute ozone inhalation promotes activation of the sympathetic and hypothalamic-pituitary-adrenal (HPA) axis leading to release of cortisol and epinephrine from the adrenals. Adrenalectomy (ADREX) inhibits ozone-induced pulmonary vascular leakage and ...

Land surface modeling (LSM) is important in WRF/CMAQ for simulating the exchange of heat, moisture, momentum, trace atmospheric chemicals, and windblown dust between the land surface and the atmosphere.? Vegetation and soil treatments are crucial in LSM for surface energy budgets...

Recent advances in vitro assays, in silico tools, and systems biology approaches provide opportunities for refined mechanistic understanding for chemical safety assessment that will ultimately lead to reduced reliance on animal-based methods. With the U.S. commercial chemical lan...

This presentation describes EPA efforts to collect, model, and measure publically available consumer product data for use in exposure assessment. The development of the ORD Chemicals and Products database will be described, as will machine-learning based models for predicting ch...

EPA&rsquo;s Office of Research and Development (ORD) is leading several efforts to develop data and methods for estimating population chemical exposures related to the use of consumer products. New curated chemical, ingredient, and product use information are being collected fro...

This presentation describes an EPA effort to improve the understanding of well pad emissions and remote measurement methods, and identify areas where future work is needed. Funded through an R8 RARE, R8, ORD, and OAQPS conducted a two-phase project to explore a novel measuremen...

In preparation for a Society of Environmental Toxicology and Chemistry Pellston Workshop titled &ldquo;Advancing the Adverse Outcome Pathway (AOP) Concept: An International Horizon Scanning Approach,&rdquo; a horizon scanning effort was undertaken to gather input from the global ...

Increased attention to the links between built and natural environments and public health, coupled with initiatives at the state, regional, and federal levels to incorporate environmental and human health in planning and policy decision-making may signal new opportunities for the...

Vascular development commences with de novo assembly of a primary capillary plexus (vasculogenesis) followed by its expansion (angiogenesis) and maturation (angio-adaptation) into a hierarchical system of arteries and veins. These processes are tightly regulated by genetic signal...

Abstract: As the community of toxicological researchers, risk assessors, and risk managers adopt the adverse outcome pathway (AOP) paradigm for organizing toxicological knowledge, the number and diversity of adverse outcome pathways and AOP networks are continuing to grow. This ...

Product Description:The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental ...

Screening and testing for endocrine active chemicals was mandated under 1996 amendments to the Safe Drinking Water Act and Food Quality Protection Act. Efficiencies can be gained in the endocrine disruptor screening program by using available biological and toxicological knowledg...

In order to study spray drift contribution to non-targeted habitats, pesticide concentrations were measured in stemflow (water flowing down the trunk of a tree during a rain event), rainfall, and amphibians in an agriculturally impacted wetland area near Tifton, Georgia, USA. Agr...

Children are more vulnerable to exposures from their everyday environments compared to adults. Children from Tribal communities have a greater burden of adverse health and well-being outcomes versus children from other communities in the U.S. (US DHHS 2016). Stressors from chi...

Dr. Michael Breen is leading the development of air pollution exposure models, integrated with novel personal sensor technologies, to improve exposure and risk assessments for individuals in health studies. He is co-investigator for multiple health studies assessing the exposure ...

OTAQ generated slides on general air quality management in the U.S. pertinent to mobile source emissions control

Air Quality and Heart Health: An Emerging Topic for Heart Month: Ambient air particle pollution increases short- and long-term cardiovascular morbidity and mortality. Older-people, those with pre-existing heart disease and lung disease and diabetes are at higher risk. Mechanism...

Dr. Cascio will share with a broad range of federal agencies current understanding of the links between air quality and cardiovascular health. The key facts include that air pollution contributes a high attributable health burden. That certain well-defined vulnerable subpopulat...