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Records 1 to
25
of 38 records published between 09/22/2012 and 09/22/2017 from author John Nichols
2017
Armitage, J., R. Erickson, T. Luckenbach, C. Ng, R. Prosser, J. Arnot, K. Schirmer, AND J. Nichols. Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 36(4):882-879, (2017).
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 36(2):463-471, (2017).
Haselman, J., J. Nichols, M. Hornung, Pat Kosian, J. Olker, Joe Korte, AND S. Degitz. Computational modeling of the amphibian thyroid axis supported by targeted in vivo testing to advance quantitative adverse outcome pathway development. National Society of Toxicology Annual Meeting, Baltimore, MD, March 12 - 16, 2017.
Ingle, B., B. Veber, J. Nichols, J. Wambaugh, AND R. Tornero-Velez. Designing a Quantitative Structure-Activity Relationship for the Intrinsic Metabolic Clearance of Environmentally Relevant Chemicals. Presented at Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12 - 16, 2017.
Ingle, B., B. Veber, J. Nichols, J. Wambaugh, AND R. Tornero-Velez. In Silico Prediction of Toxicokinetic Parameters for Environmentally Relevant Chemicals for Risk-Based Prioritization. OpenTox USA 2017, Durham, NC, July 12 - 13, 2017.
2016
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. setac north america, Orlando, FL, November 06 - 10, 2016.
Saunders, L., A. Hoffman, J. Nichols, AND F. Gobas. Concentration dependence of in vivo biotransformation rates of organic sunscreen agents in rainbow trout following a dietary exposure. SETAC North America, Orlando, FL, November 06 - 10, 2016.
Ingle, B., B. Veber, J. Nichols, AND R. Tornero-Velez. Human health and the environment: Predicting plasma protein binding and metabolic clearance rates of environmentally relevant chemicals. American Chemical Society Nat'l Meeting, San Diego, CA, San Diego, CA, March 13 - 17, 2016.
Embry, M., K. Fay, M. Bernard, I. Bischof, J. Davis, J. Domoradzki, M. Halder, J. Hu, K. Johanning, H. Laue, J. Nichols, H. Peterson, C. Schlechtriem, H. Segner, AND J. Weeks. In vitro to in vivo extrapolation of hepatic metabolism in fish: An inter-laboratory comparison of in vitro methods - presentation. SETAC North America, Orlando, FL, November 06 - 10, 2016.
Ingle, B., R. Tornero-Velez, J. Nichols, AND B. Veber. Informing the Human Plasma Protein Binding of Environmental Chemicals by Machine Learning in the Pharmaceutical Space: Applicability Domain and Limits of Predictability. Journal of Chemical Information and Modeling. American Chemical Society, Washington, DC, 56(11):2243-2252, (2016).
Ladd, M., P. Fitzsimmons, AND J. Nichols. Optimization of a UDP-glucuronosyltransferase assay for trout liver S9 fractions: Activity enhancement by alamethicin, a pore-forming peptide. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, 46(12):1066-1075, (2016).
Nichols, J., L. Saunders, AND F. Gobas. Physiologically based modeling of hepatic and gastrointestinal biotransformation in fish. SETAC North America, Orlando, FL, November 06 - 10, 2016.
Ingle, B., B. Veber, J. Nichols, AND R. Tornero-Velez. Toxicity challenges in environmental chemicals: Prediction of human plasma protein binding through quantitative structure-activity relationship (QSAR) models. IVIE Workshop RTP, NC, RTP, NC, February 17, 2016.
Ingle, B., B. Veber, J. Nichols, AND R. Tornero-Velez. Toxicity challenges in environmental chemicals: Prediction of human plasma protein binding through quantitative structure-activity relationship (QSAR) models (2016 IVIVE Workshop Proceedings). In Proceedings, IVIVE Workshop, RTP, NC, February 17, 2016. U.S. Department of Health & Human Services, NIEHS, Research Triangle Park, NC, 4, (2016).
Consoer, D., A. Hoffman, P. Fitzsimmons, Pat Kosian, AND J. Nichols. Toxicokinetics of perfluorooctane sulfonate in rainbow trout (Oncorhynchus mykiss). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 35(3):717-727, (2016).
Chen, Y., J. Hermens, M. Jonkers, J. Arnot, J. Armitage, T. Brown, J. Nichols, K. Fay, AND S. Droge. Which molecular features affect the intrinsic hepatic clearance rate of ionizable organic chemicals in fish? ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50:12722-12730, (2016).
2015
Nichols, J. Frontiers of chemical bioaccumulation modeling with fish. UMD Seminar, Duluth, MN, March 27, 2015.
Fay, K., M. Embry, M. Bernard, I. Bischof, J. Davis, J. Domoradzki, M. Halder, X. Han, K. Johanning, H. Laue, D. Nabb, J. Nichols, C. Schlechtriem, H. Segner, L. van der Wal, AND J. Weeks. In vitro to In vivo extrapolation of hepatic metabolism in fish: An inter-laboratory comparison of In vitro methods. SETAC North America, Salt Lake City, UT, November 01 - 05, 2015.
Nichols, J., B. Du, R. Erickson, A. Hoffman, J. Berninger, C. Chambliss, K. Connors, AND B. Brooks. Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, by fathead minnows. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 34(6):1425-1435, (2015).
Nichols, J., F. Gobas, M. McLeod, K. Borgi, P. Leonards, P. Ester, H. Laue, AND J. Arnot. Summary of Cefic-LRI sponsored workshop: Recent scientific developments in bioaccumulation research. In Proceedings, Cefic-LRI-Field Research, Helsinki, FINLAND, September 24, 2014. Cefic, Brussels, Belgium, 1-13, (2015).
2014
Nichols, J., M. Hornung, Joe Korte, J. Haselman, Joe Tietge, AND S. Degitz. A quantitative adverse outcome pathway model for thyroid axis disruption in Xenopus laevis tadpoles. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.
Armitage, J., G. Rattray, AND J. Nichols. Experts Workshop on the Ecotoxicological Risk Assessment of Ionizable Organic Chemicals: Bioaccumulation/ADME. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.
Gouin, T., B. Brooks, M. Bonnell, J. Armitage, B. Escher, T. Henry, M. Lam, J. Nichols, G. Rattray, G. Stringer, T. Valenti, AND M. Embry. Experts workshop on the ecotoxicological risk assessment of ionizable organic chemicals: Towards a science-based framework for chemical assessment. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.
Fay, K., R. Mingoia, I. Goeritz, D. Nabb, A. Hoffman, B. Ferrell, H. Peterson, J. Nichols, H. Segner, AND X. Han. Intra- and inter-laboratory reliability of a cryopreserved trout hepatocyte assay for the prediction of chemical bioaccumulation potential. ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 48(14):8170-8178, (2014).
Connors, K., B. Du, P. Fitzsimmons, K. Chambliss, J. Nichols, AND B. Brooks. Method optimization for fathead minnow (Pimephales promelas) liver S9 isolation. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.