Science Inventory

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Leonard, J., C. Stevens, K. Mansouri, D. Chang, H. Pudukodu, S. Smith, AND C. Tan. A Workflow for Identifying Metabolically Active Chemicals to Complement in vitro Toxicity Screening. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 6:71-83, (2018).

Tan, C. A tiered approach to incorporate exposure and pharmacokinetics considerations in in vitro based safety assessment. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Tan, C., J. Leonard, S. Edwards, J. Teeguarden, A. Paini, AND P. Egeghy. Aggregate exposure pathways in support of risk assessment. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 9:8-13, (2018).

Worley, R., J. Leonard, J. Fisher, AND C. Tan. Approaches for Increasing Acceptance of Physiologically Based Pharmacokinetic Models in Public Health Risk Assessment. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Tan, C., R. Worley, J. Leonard, AND J. Fisher. Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 162(2):341-348, (2018).

Setzer, Woodrow AND C. Tan. EURL ECVAM WORKSHOP ON NEW GENERATION OF PHYSIOLOGICALLY-BASED KINETIC MODELS IN RISK ASSESSMENT. Publications Office of the European Union, , Luxembourg, 2018. https://doi.org/10.2760/619902

Leonard, J., H. El-Masri, C. Stevens, K. Mansouri, AND C. Tan. Integrating Exposure, Pharmacokinetics, And Dosimetry With In Vitro Dose-Response Data To Evaluate Chemical Risk. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.

Tan, C., J. Leonard, S. Edwards, J. Teeguarden, AND P. Egeghy. Refining the aggregate exposure pathway. Environmental Science: Processes & Impacts. RSC Publishing, Cambridge, Uk, 3(20):428-436, (2018).

Edwards, S., C. Tan, J. Leonard, P. Egeghy, AND J. Teeguarden. A conceptual framework to advance exposure science research and complement the Adverse Outcome Pathway framework. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Leonard, J., D. Chang, H. El-Masri, S. Edwards, C. Stevens, K. Mansouri, P. Egeghy, AND C. Tan. A tiered approach for integrating exposure and dosimetry with in vitro dose-response data in the modern risk assessment paradigm. 254th ACS National Meeting & Exposition, Washington, DC, August 20 - 24, 2017.

Tan, C. Applying Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks to link toxicity testing data to exposure-relevant and biologically-relevant responses. Opentox USA 2017, Durham, NC, July 12 - 13, 2017.

Leonard, J. AND C. Tan. Complementing in vitro hazard assessment with exposure and pharmacokinetics considerations for chemical prioritization. 2017 ISES Annual Meeting, Durham, NC, October 15 - 19, 2017.

Tan, C. Complementing in vitro screening assays with in silico molecular chemistry tools to examine potential in vivo metabolite-mediated effects. 2017 Society of Toxicology Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Grulke, Chris, Rocky Goldsmith, R. Brooks, D. Chang, C. Tan, R. Tornero-Velez, AND K. Holm. Enabling PBPK model development through the application of freely available techniques for the creation of a chemically-annotatedcollection of literature. Presented at American Chemical Society, San Francisco, CA, August 10 - 14, 2014.

Lee, S., C. Tan, M. Phillips, J. Sobus, AND S. Kim. Estimating Methylmercury Intake for the General Population of South Korea Using Physiologically Based Pharmacokinetic Modeling. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 159(1):6-15, (2017).

Tan, C. Frameworks for organizing exposure and toxicity data - the Aggregate Exposure Pathway (AEP) and the Adverse Outcome Pathway (AOP). 2017 ISES Annual Meeting, Durham, NC, October 15 - 19, 2017.

Escher, B., J. Hackermüller, T. Polte, S. Scholz, A. Aigner, R. Altenburger, A. Bohme, S. Bopp, W. Brack, W. Busch, M. Chadeau-Hyam, A. Covaci, A. Eisentrager, J. Galligan, N. Garcia-Reyero, T. Hartung, M. Hein, G. Herberth, A. Jahnke, J. Kleinjans, N. Kluever, M. Krauss, M. Lamoree, I. Lehmann, T. Luckenbach, G. Miller, A. Mueller, D. Phillips, T. Reemtsma, U. Rolle-Kampczyk, G. Schuurmann, B. Schwikowski, C. Tan, S. Trump, S. Walter-Rohde, AND J. Wambaugh. From the exposome to mechanistic understanding of chemical-induced adverse effects. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 99:97-106, (2017).

Leonard, J., C. Stevens, K. Mansouri, D. Chang, AND C. Tan. Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Model for Estrogen Receptor Binding. SOT Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Leonard, J., C. Stevens, K. Mansouri, D. Chang, AND C. Tan. Identifying Metabolically Active Chemicals Using a Consensus Quantitative Structure Activity Relationship Model for Estrogen Receptor Binding. Opentox USA 2017, Durham, NC, July 12 - 13, 2017.

Tan, C. Improving Public Health through Innovations in Exposure Science. Socieity of Toxicology Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Tan, C. Integrating Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Estimate Exposure-relevant Responses. JRC Workshop: Fit-For-Purpose Exposure Assessment For Risk-Based Decision Making, Como, ITALY, June 20, 2017.

Paini, A., J. Leonard, T. Kliment, C. Tan, AND A. Worth. Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 90:104-115, (2017).

Oki, N., J. Leonard, M. Nelms, S. Bell, C. Tan, L. Burgoon, AND S. Edwards. Linking Environmental Exposure to Toxicity. Chapter 4, Issues in Toxicology: Computational Systems Pharmacology & Toxicology. Royal Society of Chemistry, Cambridge, Uk, , 60-88, (2017). https://doi.org/10.1039/9781782623731-00060

Tan, C. AND A. Paini. Physiologically-based kinetic modelling in risk assessment. 2017 ISES Annual Meeting, Research Triangle Park, NC, October 15 - 19, 2017.

Mansouri, K., J. Leonard, C. Tan, M. Yoon, P. McMullen, AND R. Clewell. Scoring and ranking of metabolic trees to computationally prioritize chemicals for testing using fit-for-purpose in vitro estrogen receptor assay. OpenTox USA 2017, Durham, NC, July 12 - 13, 2017.