Science Inventory

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Gene drives are a topic of growing interest since the CRISPR/Cas9 system was discovered. In 2016, the National Academies published a report about science, governance, and engagement related to gene drive research and testing. There are valuable insights in all chapters, but espec...

This report outlines an approach to construct a developmental toxicity ontology. Such an ontology will facilitate computer-based prediction of substances likely to induce human developmental toxicity.

Projected increases in ocean pCO2 levels are anticipated to affect calcifying organisms more rapidly and to a greater extent than other marine organisms. The effects of ocean acidification (OA) have been documented in numerous species of corals in laboratory studies, largely test...

Many watershed models simulate overland and instream microbial fate and transport, but few provide loading rates on land surfaces and point sources to the waterbody network. This paper describes the underlying equations for microbial loading rates associated with 1) land-applied ...

Coastal ecosystems are inherently complex and potentially adaptive as they respond to changes in nutrient loads and climate. We documented the role that carbon stable isotope (&delta;13C) measurements could play in understanding that adaptation with a series of three Ecostat (i.e...

Xenobiotic exposures affect the maternal and/or in utero environment resulting in impairments in fetal development. During the period of rapid fetal growth, underdeveloped cardiovascular systems are especially vulnerable to their environment. Furthermore, fetal exposures can evok...

BACKGROUND: Wildfire smoke is known to exacerbate respiratory conditions; however, evidence for cardiovascular and cerebrovascular events has been inconsistent, despite biological plausibility. METHODS AND RESULTS: A population-based epidemiologic analysis was conducted for dail...

Intestinal enterococci are enumerated from bathing water in the European Union Member States by using the standard method ISO 7899-2 (2000). The objective of the study was to evaluate the performance characteristics of the ISO 7899-2 method with 21 water samples collected from th...

The transformation of cerium oxide nanoparticles (CeO2-NPs) in soil and its role in plant uptake is a critical knowledge gap in the literature. This study investigated the reduction and speciation of CeO2-NPs in barley (Hordeum vulgare L.) cultivated in soil amended with 250 mg C...

This journal article studied the partitioning of Cs between airborne particulate and residual ash from burning Cs-contaminated vegetation as a function of particle size distribution (PSD), and to correlate Cs emissions with carbon-containing compounds and combustion efficiency.

The development and application of physiologically based pharmacokinetic (PBPK) models in chemical toxicology have grown steadily since their emergence in the 1980s. However, critical evaluation of PBPK models to support public health decision-making across federal agencies has t...

There are challenges associated with performing research on titanium dioxide NPs in aquatic environments particularly marine systems. A critical focus for current titanium dioxide NP research in aquatic environments needs to be on optimizing methods for differentiating naturally...

Controlled human exposure to the oxidant air pollutant ozone causes decrements in lung function and increased inflammation as evidenced by neutrophil influx into the lung and increased levels of proinflammatory cytokines in the airways. Here we describe a targeted metabolomics ev...

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally-invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid (CSF) have great po...

Fluvial geomorphology provides the basis for characterizing complex river networks and evaluating biophysical processes within watersheds. Understanding the spatial organization of morphological features, their influencing processes, and resultant geomorphic diversity in stream n...

The analytical capabilities associated with the use of silylation reactions have been extended to a new class of organic molecules, nitroaromatic compounds (NACs). These compounds are a possible contributor to urban particulate matter of secondary origin which would make them imp...

Given the potential for human exposure to silver nanoparticles from spray disinfectants and dietary supplements, we characterized the silver-containing nanoparticles in 22 commercial products that advertised the use of silver or colloidal silver as the active ingredient. Characte...

This study investigates the composition of organic particulate matter in a remote montane forest in the southeastern U.S., focusing on the role of organic nitrogen (N) in sulfur-containing secondary organic aerosol (nitrooxy-organosulfates) and aerosols associated with biomass bu...

Smart new strategies to design, produce, and use safer chemicals to minimize risks and prevent pollution are a priority for the U.S. Environmental Protection Agency (EPA). EPA is developing a comprehensive approach to enhance the Agency’s management of existing chemicals and emer...

Lysosomes have a central role in cellular catabolism, trafficking, and processing of foreign particles. Accumulation of endogenous and exogenous materials in lysosomes represents a common finding in nonclinical toxicity studies. Histologically, these accumulations often lack dist...

Modeled source attribution information from the Community Multiscale Air Quality model was coupled with ambient data from the 2011 Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality Baltimore field study. We assess ...

Emissions from open burning of Meals, Ready-To-Eat (MRE) and MRE packaging were characterized in response to inhalation concerns at military forward operating bases. Emissions from four compositions of MREs and four types of packaging were compared to assess contributions of ind...

Childhood obesity in the United States has doubled over the last three decades and currently affects 17% of children and adolescents. While much research has focused on individual behaviors impacting obesity, little research has emphasized the complex interactions of numerous che...

The increasing emission of primary and gaseous precursors of secondarily formed atmospheric particulate matter due to continuing industrial development and urbanization are leading to an increased public awareness of environmental issues and human health risks in China. As part o...

Swimming and recreating in lakes, oceans, and rivers is common, yet the literature suggests children may be at greater risk of illness following such exposures. These effects might be due to differences in immunity or differing behavioral factors such as poorer hygiene, longer ex...