Office of Research and Development Publications

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Speciated volatile and semi-volatile organic compound emissions (VOCs and SVOCs, resp.), including mobile source air toxics (MSATs), were characterized in vehicle exhaust from three modern gasoline direct injection (GDI) light-duty vehicles. The test vehicles were in the U.S. EPA...

The Integrated Approach to Testing and Assessment (IATA) has been clarified further to demonstrate that a subset of as few as 4 assays is recommended as an alternative approach to the current guideline. The subset of assays can be any assays that fit into specific criteria as de...

The use of cerium oxide nanoparticles (CeNPs) in fuel additives and other industrial products may result in the accumulation of these nanoparticles in terrestrial compartments. The biological interaction between CeNPs, plants, and the root-associated microbiome is poorly understo...

This meeting is to help develop more robust estimates of land use change in the U.S. and will contribute to the Third Triennial Report to Congress on Biofuels. Understanding the amount and attribution of land use change in the U.S. remains a priority. Improved methodologies will ...

A critical component of any regulatory decision is an understanding of the uncertainty and variability surrounding the important factors underlying the decision. In this context, uncertainty is defined as a lack of knowledge, while variability measures the true differences across...

Acetylcholinesterase (AChE) inhibition can have significant impacts on human health. A large number of environmental chemicals such as synthesized drug candidates, food additives, and industrial chemicals have not been tested for AChE inhibition activity. Moreover, some chemicals...

Predicting and characterizing potential human teratogenic compounds remains a challenge as toxicology moves towards new approach methods (NAMs) for hazard identification with animal models remaining the ‘gold’ standard for assessing developmental toxicity in humans. Utilizing plu...

NTA methods are considered a qualitative analysis type, forgoing chemical standards (often because they are not available), and producing semi-quantitative concentration data using surrogate calibration techniques. Data collection for NTA experiments focuses on being as inclusive...

The identification of chemicals in environment media depends on the application of analytical methods, the primary approach being one of the multiple mass spectrometry techniques. Cheminformatics solutions are critical to supporting the chemical identification process. This inclu...

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally-invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid (CSF) have great po...

The presentation describes the methodology and results for clustering 187 biorefineries into 13 representative clusters. The problem is that detailed geographic analysis with photographic ground truthing can only be conducted on ~15 biorefineries within the project scope. How do ...

Regional Monitoring Networks (RMNs) bring together a diverse set of partners from EPA, state agencies, tribes, federal partners, and other entities. The goal of this collaborative effort is to collect long-term biological, thermal, hydrologic, physical habitat and water chemistry...

A multi-agency, collaborative effort was completed in the fall of 2016 and summer of 2017 to provide a baseline assessment of pre-remedial conditions. Multiple state and federal agencies (U.S. Army Corps of Engineers (USACE), U.S. EPA ORD, U.S. EPA GLNPO, USGS and Minnesota Pollu...

This poster provides information on EPA's small drinking water systems communications and outreach activities.

The CompTox Chemistry Dashboard has been available online for three years and has become the primary web application to source data from the US EPA National Center for Computational Toxicology. In vitro high-throughput screening data, in vivo hazard data, exposure data in terms o...

This talk will give an overview of changes made since the August 2018 release with new data enhancements and new user interface elements. We will also cover work in progress and future plans for features and functionality.

Information and data on chemicals is used by scientists to evaluate potential health and ecological risks due to environmental exposures. EPA’s CompTox Chemicals Dashboard (https://comptox.epa.gov) helps evaluate the safety of chemicals by providing public access to a variety of ...

Peat and eucalyptus smoke produces equivalent toxicity between flaming and&middot; smoldering conditions despite tenfold lower PM concentrations for flaming Smoke from oak combustion is less toxic than that from peat or eucalyptus Smoke inhalation has significant eff...

Soil and dust are the predominant sources of Pb exposure for children in the United States. Although quantitation of the intake of Pb from soil and dust ingestion is problematic, the importance of these sources is emphasized by studies that show that reducing levels of Pb in soil...

To maximize the ability to detect differences in communities before and after projects or in different reaches, a macroinvertebrate sampling method is desired which can deal with flashy flow patterns, is relatively quantitative, and retrieves a high proportion of the taxa present...

We would like to know more about the risk posed by thousands of chemicals in the environment – which ones should we start with? High throughput screening (HTS) provides one path forward for identifying potential hazard, but the real world is complicated by toxicokinetics, mixture...

Computational modeling of structural features of an in vitro assay can provide mechanistic insights into assay data. Here we describe computational modeling of an assay where primary rat cortical cells are grown over a microelectrode array for up to 12 days in vitro (DIV). As the...

High resolution mass spectrometry (HRMS) and non-targeted analysis (NTA) have advanced structure identification of unknowns in various sources including environmental media and food stuffs. Structure identification requires the integration of complementary data types such as ref...

The US EPA’s National Center for Computational Toxicology (NCCT) is focused on developing computational estimates of the toxicology of chemicals found in commerce and in the environment. In order to deliver predictive models NCCT has measured, assembled and delivered an enormous ...

This poster discusses an EPA communications tool for selecting point of use (POU) drinking water filters certified to reduce lead.