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The Alginate Immobilization of Metabolic Enzymes (AIME) is a high-throughput screening (HTS)-compatible platform that retrofits existing in vitro assays with metabolic competence by attaching alginate-hepatic S9 microspheres to solid supports extending from custom microplate lids...

A common intended function of green infrastructure is management of urban ecosystem water cycles. The shape of land, specifically its hillslopes, within watersheds regulates the movement of water from uplands to streams. Thus, managing water cycling within watersheds requires wor...

Allergic hypersensitivity represents a significant public health problem. Consequently, it is imperative that toxicologists possess a fundamental understanding of hypersensitivity responses. This lecture will provide graduate students studying toxicology at UNC Chapel Hill with a...

Numerous chemicals are proposed to produce non-receptor/ion-channel mediated neurotoxic responses through adverse interactions with intracellular proteins and macromolecules. These molecular initiating events may induce an adverse outcome pathway (AOP) that can hinder synaptic ne...

Antony Williams is a Computational Chemist at the US Environmental Protection Agency in the National Center for Computational Toxicology. He has been involved in cheminformatics and the dissemination of chemical information for over thirty years. He has worked at a university as ...

The evaluation of potential alternatives for chemicals of concern (CoC) requires an understanding of their potential human health and environmental impacts during the manufacture, use, recycle and disposal life stages. During the manufacturing phase, the processes used to produce...

Coral reefs worldwide have degraded during the last five decades. Protection of reefs is challenging because of the many watershed, coastal and oceanic stressors that affect them. There are numerous actions that can be taken to reduce coral reef stressors, but implementation nece...

Background: Literature based chemical assessments have adopted systematic review methods and systematic maps to ensure rigor, transparency, and identification of all the evidence relevant to answering a question. This is a significant semantic challenge because different communit...

Traditional structure-activity relationship (SAR) approaches to modeling in toxicology are bounded and determined by the chemicals in the tested space, and are limited by such factors as size and structure diversity of that tested space, mechanistic diversity of the activity endp...

Non-targeted and suspect screening studies using high resolution mass spectrometry (HRMS) have revolutionized the detection of chemicals in complex matrices. However, data processing remains challenging due to the vast number of chemicals detected in samples, software and comput...

High resolution mass spectrometry (HRMS) and non-targeted analysis (NTA) are of increasing interest in chemical forensics for the identification of emerging contaminants and chemical signatures of interest. At the US Environmental Protection Agency, our research using HRMS for no...

High resolution mass spectrometry (HRMS) and non-targeted analysis (NTA) are of increasing interest in chemical forensics for the identification of environmental chemical contaminants. At the US Environmental Protection Agency, our research using HRMS for non-targeted and suspect...

Social scientists at EPA-ORD-AED conduct a range of different research efforts in southern New England and beyond. This presentation will discuss broadly three of these efforts in terms of their methods and use in the local context. The three projects that we will be discussing a...

The amount of citizen science activities, applications and data have increased exponentially in the last few years. Fortunately, most of this data has been digitized, or is collected electronically through smart phone applications and websites, so that it is quickly archived and...

The U.S. Environmental Protection Agency is evaluating methods to screen and prioritize organophosphorus (OP) pesticides for developmental toxicity and developmental neurotoxicity (DNT). One of those methods uses larval zebrafish. Developmental toxicity in zebrafish embryos/larva...

Global economic development and an increasing population have dramatically increased demand for water resources. Anthropogenic chemicals released from waste water treatment plants (WWTP), as well as industrial and agricultural operations, often negatively affect the quality of re...

Evaluating the Toxicity of Silver Nanoparticles in ARPE-19 Cells Through High Content Morphometric Analysis A. Goldstein-Plesser, J. Nyffeler, C. Willis, J. Harrill, W. Boyes Efficient methods are needed to evaluate the human and environmental health effects of silver nanoparticl...

Vehicle automation has the potential to drastically transform the transportation system, which would in turn have energy and environmental implications. There is considerable uncertainty regarding the effect of automation on travel demand and efficiency. We utilize the MARKet ALl...

High-throughput imaging-based phenotypic profiling (HTPP) is a chemical screening method that combines automated microscopy and image analysis to measure a large variety of morphological features at the single cell level. Here we describe workflows for concentration-response scre...

There are over half a million abandoned mine sites in the U.S. potentially emanating mining-influenced water, contaminating streams and soils in adjacent areas. These sites present major challenges for their remediation, including: seasonal inaccessibility, rough terrain, lack of...

Adverse outcome pathways (AOPs) describe a sequence of events, beginning with a molecular initiating event (MIE), proceeding via key events (KEs), and culminating in an adverse outcome (AO). A challenge for use of AOPs in a safety evaluation context has been identification of MI...

Arsenic exposure has been associated with numerous diseases ranging from cancers of the bladder, skin and lung, to metabolic diseases such as cardiovascular disease and diabetes mellitus, as well as adverse pregnancy outcomes such as spontaneous abortions, low birth weights, and ...

Many of the Midwestern US &ldquo;Rust Belt&rdquo; cities contain Areas of Concern (AOC) where extensive efforts to remediate aquatic sediments, restore riparian habitat and ecosystem services, and realize community revitalization are unfolding. USEPA has coined the term &ldquo;Re...

In this presentation, we bring combine the US EPA's indexes of local catchment and watershed integrity (ICI and IWI) with a Biological Condition Gradient (BCG) developed for the Puget Sound, WA. The BCG is an indicator of the ecological condition of streams based on macroinverteb...

&alpha;-Aminonitriles are very useful in the synthesis of bioactive natural products and pharmaceutically important heterocycles.1 The transition metal catalyzed C-H activation followed by cyanation is the most straightforward possible reaction sequence used to accomplish this tr...