Science Inventory

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Doering, J., S. Lee, K. Kristiansen, L. Evenseth, M. Barron, I. Sylte, AND C. LaLone. In silico site-directed mutagenesis informs species-specific predictions of chemical susceptibility derived from the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 166(1):131-145, (2018). https://doi.org/10.1093/toxsci/kfy186

LaLone, C. AND J. Doering. PT08 application of the USEPA SeqAPASS tool to address challenges of cross-species extrapolation of toxicity information. SETAC North America, Sacramento, CA, November 04 - 08, 2018.

LaLone, C., J. Doering, G. Ankley, S. Degitz, AND Dan Villeneuve. SeqAPASS to evaluate conservation of high-throughput screening targets across non-mammalian species. SETAC Europe, Rome, ITALY, May 13 - 17, 2018.

LaLone, C. SeqAPASS tool briefing. Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology, Paris, N/A, FRANCE, October 25 - 26, 2018.

LaLone, C. SeqAPASS v3.0 for Extrapolation of Toxicity Knowledge Across Species. NTP Interagency Center for theEvaluation of Alternative Toxicological Methods, Duluth, MN, May 29, 2018.

LaLone, C. Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) Version 3.0 User Guide. U.S. EPA Office of Research and Development, Washington, DC, EPA/600/R-18/062, 2018.

LaLone, C., G. Ankley, S. Belanger, M. Embry, G. Hodges, D. Knapen, S. Munn, E. Perkins, M. Rudd, Dan Villeneuve, M. Whelan, C. Willett, X. Zhang, AND M. Hecker. Setting the stage to advance the adverse outcome pathway (AOP) framework through horizon scanning. SETAC Europe, Rome, ITALY, May 13 - 17, 2018.

Doering, J., G. Ankley, B. Blackwell, K. Dean, C. LaLone, S. Poole, AND Dan Villeneuve. Strategically selecting test species using the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool. SETAC North America, Sacramento, CA, November 04 - 08, 2018.

LaLone, C. The ECOTOX Knowledgebase pipeline: From literature search to data extraction. Chemicals Committee- Working Party on Chemicals, Pesticides and Biotechnology, paris, N/A, FRANCE, October 25 - 26, 2018.

LaLone, C., Dan Villeneuve, J. Doering, B. Blackwell, T. Transue, C. Simmons, J. Swintek, S. Degitz, A. Williams, AND G. Ankley. ToxCast results to identify chemical hazards across species. SETAC North America, Sacramento, CA, November 02 - 08, 2018.

Houck, K., C. LaLone, A. Bone, R. Judson, M. Martin, Dan Villeneuve, G. Ankley, A. Medvedev, AND S. Markarov. A Multi-Receptor and Multi-Species Assay for Potential Endocrine Disruptor Targets (SLAS meeting). Presented at 2017 SLAS meeting, Washington, DC, February 04 - 08, 2017. https://doi.org/10.23645/epacomptox.5181265

Fay, K., C. LaLone, D. Feifarek, J. Doering, J. Cavallin, Dan Villeneuve, AND G. Ankley. Addressing species diversity in biotransformation: Variability in expressed transcripts of Phase I and II hepatic enzymes among fishes. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

LaLone, C., G. Ankley, S. Belanger, M. Embry, G. Hodges, D. Knapen, S. Munn, E. Perkins, M. Rudd, Dan Villeneuve, M. Whelan, C. Willett, X. Zhang, AND M. Hecker. Advancing the Adverse Outcome Pathway Framework - an International Horizon Scanning Approach. SOCIETY OF ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY JOURNAL. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 36(6):1411-1421, (2017).

LaLone, C., G. Ankley, S. Belanger, M. Embry, G. Hodges, D. Knapen, S. Munn, E. Perkins, M. Rudd, Dan Villeneuve, M. Whelan, C. Willett, X. Zhang, AND M. Hecker. Advancing the adverse outcome pathway framework - An international horizon scanning approach (presentation). SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

Doering, J., G. Ankley, B. Blackwell, J. Cavallin, K. Fay, D. Feifarek, K. Jensen, M. Kahl, C. LaLone, S. Poole, E. Randolph, AND Dan Villeneuve. Assessment of differences in sensitivity to aromatase inhibitors among freshwater fish species. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

LaLone, C. AND J. Doering. Cross-species extrapolation of an adverse outcome pathway for ecdysone receptor activation. EDRISK final workshop, Oslo, NORWAY, October 21 - 28, 2017.

Mortensen, H., M. Pittman, C. LaLone, AND S. Edwards. Defining a Computational Framework for the Assessment of Taxonomic Applicability. SOT, Baltimore, MD, March 12 - 16, 2017.

Martinovic-Weigelt, D., A. Mehinto, G. Ankley, J. Berninger, Tim Collette, J. Davis, N. Denslow, E. Durhan, E. Eid, D. Ekman, K. Jensen, M. Kahl, C. LaLone, Q. Teng, AND Dan Villeneuve. Derivation and evaluation of putative adverse outcome pathways for the effects of cyclooxygenase inhibitors on reproductive processes in female fish. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 156(2):344-361, (2017).

Elonen, C., J. Olker, C. LaLone, D. Hoff, S. Erickson, M. Skopinski, C. Horn, S. Casey, AND A. Pilli. ECOTOX knowledgebase: New tools for data visualization and database interoperability. SETAC, Minneapolis, MN, November 12 - 16, 2017.

Houck, K., C. LaLone, R. Judson, M. Martin, Dan Villeneuve, G. Ankley, A. Medvedev, AND S. Markarorav. Evaluation of an In Vitro Multi-Receptor and Multi-Species Assay for Potential Endocrine Disruptor Targets (SOT). Presented at SOT National Meeting, Baltimore, MD, March 12 - 16, 2017.

LaLone, C. Extrapolating toxicity data across species using U.S. EPA SeqAPASS tool. OECD Endocrine Disruptor Testing and Assessment (EDTA), Duluth, MN, October 04, 2017.

LaLone, C. Extrapolation of mammalian-based ToxCast assay results to non-mammalian species to evaluate endocrine disruption. Fresenius Conference ‘Endocrine Disruptors’, Cologne, GERMANY, November 29 - 30, 2017.

Hoff, D., J. Olker, C. Elonen, AND C. LaLone. New applications in EPA’s ECOTOX Knowledge System: Assimilating relative potencies of metals across chemical and biological species from literature-based toxicity effects data. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

Fay, K., Dan Villeneuve, C. LaLone, Y. Song, K. Tollefsen, AND G. Ankley. Practical approaches to adverse outcome pathway development and weight‐of‐evidence evaluation as illustrated by ecotoxicological case studies . SOCIETY OF ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY JOURNAL. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 36(6):1429–1449, (2017).

Tal, T., C. Kilty, A. Smith, C. LaLone, B. Kennedy, A. Tennant, C. McCollum, M. Bondesson, T. Knudsen, S. Padilla, AND N. Kleinstreuer. Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 70:70-81, (2017).