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Numerous qPCR-based methods are available to estimate the concentration of fecal pollution sources in surface waters. However, qPCR fecal source identification data sets often include a high proportion of non-detections (reactions failing to attain a prespecified minimal signal i...

Taxonomic data are the foundation of bioassessment and much basic and applied research. Difficulty in morphological species identification, evolving and varying taxon concepts, and nomenclatural changes can lead to significant inconsistencies in taxonomic datasets across analysts...

Water quality standards are important for protecting and restoring the condition of lakes, rivers, estuaries, and other water bodies in the United States. Given that nutrient pollution continues to be a widespread problem in aquatic systems, the development of numeric nutrient cr...

The Bayesian network (BN) session at the SETAC North America 44th Annual Meeting was conducted for the sixth consecutive year. Since its inception in 2018 during the SETAC North America annual meeting in Sacramento, the BN session has grown into a multi-faceted platform for the p...

Analytical methods, specifically those focused on the identification of chemicals by liquid and gas chromatography mass spectrometry (LC/MS and GC/MS), are key approaches supporting targeted and non-targeted environmental analysis. Different chemicals and chemical classes are ame...

Mass spectrometry analyses at the US-EPA, especially non-targeted analysis studies, are highly dependent on the cheminformatics efforts which have been underway within the agency for almost a decade. These research efforts have resulted in a rich data infrastructure based on the ...

Thyroid hormones (TH) are highly iodinated molecules that regulate many aspects of mammalian physiology and are essential for normal growth and development. Deiodinases (DIO) are a family of three metabolizing enzymes (DIO1, DIO2, DIO3) by activating or deactivating TH action. Th...

Per- and polyfluoroalkyl substances (PFAS) are used in various industrial products; however, they pose serious health risks. In this study, soil, soil gas, and groundwater samples were collected at a PFAS manufacturing facility in New Jersey, USA, to determine the presence and di...

Chemical exposure monitoring has long been performed using targeted analytical methods. These methods are validated to create standardized procedures that can be used by qualified laboratories, ultimately generating reproducible and actionable results. Despite the immense value o...

Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of chemicals in use and the high rate of drug candidate failure due to toxicity, ...

The US EPA uses exposure and toxicity information and risk assessments to protect human health and the environment from known hazards. However, some of the chemicals we are exposed to are unknown, undetected, and unregulated. Discovering the identity of unknown chemicals with mas...

US EPA has previously published a decision support tool (River Basin Export Reduction Optimization Support Tool, RBEROST) populated with data for the Upper Connecticut River Basin to allow stakeholders to determine the least-cost management strategies to meet nitrogen and phospho...

US EPA has previously published a decision support tool (River Basin Export Reduction Optimization Support Tool, RBEROST) populated with data for the Upper Connecticut River Basin to allow stakeholders to determine the least-cost management strategies to meet nitrogen and phospho...

US EPA has previously published a decision support tool (River Basin Export Reduction Optimization Support Tool, RBEROST) populated with data for the Upper Connecticut River Basin to allow stakeholders to determine the least-cost management strategies to meet nitrogen and phospho...

Assessing the fate of PFAS in the environment requires improved analytical methodologies to quantify a greater variety of PFAS and application of these methods to investigate their occurrence in complex sample matrices. PFAS precursors are a compound class of emerging concern tha...

The purpose of this letter is to correct previously reported blood serum concentrations for PFO5DoA in people in Wilmington, North Carolina (NC), in 2017-2018 [1]. Perfluoro-3,5,7,9,11-pentaoxadodecanoic acid (known as PFO5DoA; Chemical Abstracts Service Number [CASN] 39492-91-6,...

The development of field-scale, in situ screening technologies is crucial for assessing aqueous film forming foam (AFFF) source zones at former fire training and storage sites, which are long-term sources of per- and polyfluoroalkyl substances (PFAS) contamination. Spectral induc...

The potential utility of DNA-based approaches for early detection and monitoring of non-native aquatic species (NAS) has been widely recognized for more than a decade. Still, we have yet to see broad adoption of these methods by decision-makers and natural resource managers. This...

This is a requested presentation for the Association of Clean Water Administrators (ACWA) that discusses how ORD is the research arm of the EPA and provides the scientific foundation for EPA to execute its mandate to protect human health and the environment. An overview of the 6 ...

This presentation covers updates as of March 2024 regarding EPA methods for per- and polyfluoroalkyl substances (PFAS) as well as ongoing method development work within EPA Office of Research and Development (ORD). EPA Methods 1633 and 1621 were finalized on January 31, 2024. Fut...

Analytical methods can vary in nature from detailed regulatory methods to more summary in nature. Regulatory method documents can include details of analytes which can be studied, supported matrices, reagents, methodological details, statistical performance, interlaboratory valid...

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This presentation describes the development of a decision support tool, the Priority Response Environmental Screening Tool (PRESTO), that was designed to provide a framework for analyzing geospatial information. The objective of a PRESTO analysis is to assist the U.S. Environment...

Analytical methods are scattered across the internet in the form of regulatory methods, laboratory procedures, standard operating procedures, scientific publications and instrument vendor technical notes. The chemical substances in the methods are represented in a heterogeneous m...