<< Previous

Next >>

Background and Purpose: Adrenergic receptors (AR) are the most extensive therapeutically manipulated drug receptors in the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary disease. The airways are densely innervated by AR, which are cellular rec...

The EPA Office of Research and Development&rsquo;s Next Generation Emission Measurement (NGEM) program focuses on researching the deployment of lower-cost air sensors near known emissions sources. The air quality measurements collected with these sensors can be used to indicate t...

An in situ oil burn plume was characterized to provide a unique aerial data set for development and calibration of near-source dispersion models. Seven in situ burns (ISBs) were conducted on a subset of a 1 ha artificial pond. The Alaska North Slope crude oil burn plume was sampl...

Several related research efforts are in-progress in the US EPA to inform a large(r) hazard and dose-response landscape for per- and polyfluoroalkyl substances (PFAS); such data may be critical to informing data-poor mixture PFAS. The expressed objective is to identify dose-respon...

While SWMM has arguably played a pivotal role in pollution control in collection systems since its introduction, traditional applications using the model have been relatively static. They typically involve calibrating and validating SWMM models with data collected and curated for...

This is a presentation abstract for proposed session, ID 141, Advances in New Approach Methods for Thyroid Toxicity Testing, for the SOT 2024 Annual Meeting.&nbsp; Abstract: There is significant regulatory need to evaluate chemicals that may disrupt the thyroid endocrine system. ...

Chemical safety assessment begins with defining the lowest level of chemical that alters one or more measured endpoints. This critical effect level, along with factors to account for uncertainty, is used to derive limits for human exposure. In the absence of data regarding the sp...

This is a broad overview presentation covering CEMM's ambient and near-source air measurement research for an international audience. The presentation includes content related to Federal Reference Methods (FRMs) and Federal Equivalent Methods (FEMs) for the NAAQS, air sensor tech...

This is the PowerPoint slide deck for the Science to Achieve Results (STAR) &ldquo;Air Quality Information: Making Sense of Air Pollution Data to Inform Decisions in Underserved Communities Overburdened by Air Pollution&rdquo; Funding Opportunity Informational Webinar that will b...

In the United States, the Clean Air Act requires the Environmental Protection Agency (EPA) to establish National Ambient Air Quality Standards (NAAQS) and to monitor six common air pollutants. For NAAQS compliance, air quality instruments must adhere to stringent sampling, siting...

Taxonomic data are the foundation of bioassessment and much basic and applied research. Difficulty in morphological species identification, evolving and varying taxon concepts, and nomenclatural changes can lead to significant inconsistencies in taxonomic datasets across analysts...

Lead (Pb) and arsenic (As) contamination of soils is widespread in the United States and is an important source of exposure in young children. Early life exposure to metal(loid) contaminants has serious and long-lasting effects on health, making mitigation a critical public healt...

In the US there are over 20,000 abandoned hardrock mines that may present risks to human health or the environment from long-term exposure to harmful substances. One site is the Formosa mine Superfund site located in Oregon, US. The site lacks plant cover due to phytotoxic tailin...

Communities across the United States and particularly in the Midwest continue to grapple with the complications associated with aging infrastructure. This includes the presence of lead (Pb)-bearing plumbing components such as lead service lines (LSLs), downstream galvanized iron ...

A PowerPoint presentation created by the National Program Manager for Regional Laboratories to present to the Association of Public Health Laboratories.

In-situ burning (ISB) is the controlled burning of oil spilled from a vessel or pipeline. There were multiple ISB events after the Deepwater Horizon oil spill on April 20, 2010, including 410 ISBs conducted by the Coast Guard [1]. Proponents of ISB suggest that it offers a rapid ...

The Regional Monitoring Networks (RMNs) are a collaborative, volunteer effort to collect comparable long-term monitoring data at targeted sites nationwide to detect changes over time. Six Northeast states have participated in the stream RMN since it was first piloted in the North...

Per- and polyfluoroalkyl substances (PFAS) are compounds found in many consumer and industrial products with ubiquitous spread in environmental matrices. While there is evidence that some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), cause d...

Anatoxin-a (ATX) is a cyanobacterial neurotoxin produced in freshwater lakes, streams, and reservoirs both in planktonic and benthic blooms. It is a potent and irreversible nicotinic acetylcholine receptor (nAChR) agonist that causes central and peripheral effects while it is the...

EPA in partnership with 10 federal, state, local, and tribal organizations sponsored a science-based challenge to encourage development of new, effective, low-cost approaches (termed &quot;Solutions&quot;) to remove PM5 from indoor air, particularly high concentrations related to...

N/A

Water quality standards are important for protecting and restoring the condition of lakes, rivers, estuaries, and other water bodies in the United States. Given that nutrient pollution continues to be a widespread problem in aquatic systems, the development of numeric nutrient cr...

Presentation to Duke University, Toxicology &amp; Environmental Health Seminar

These are slides to give an overview of applied NAMs for hazard, using the example workflow of performing an endocrine assessment using ToxCast data and models, followed by calculation of a bioactivity:exposure ratio. Then, examples of applied bioactivity:exposure ratios or point...

Background and Purpose: Per- and polyfluoro-alkyl substances (PFAS) are a large and diverse class of organic chemicals in which all (per-) or some (poly-) carbon&ndash;hydrogen bonds have been replaced with carbon&ndash;fluorine bonds. PFAS are commonly found in human tissues. S...